Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Filtering by
- All Subjects: conservation
- All Subjects: Rexinoid
- Creators: School of Mathematical and Natural Sciences
Collective human attitudes influenced by macro-forces that impact environmental issues are partially correlated to our behaviors for the good and the harm of the planet. In this thesis, I will explore how collective human attitudes contribute to pro-environmental behaviors, common and pre-existing frames of mind on major conservation dilemmas, and finally suggest future directions on how humans could be inclined to take on more environmental responsibility through an increase in human-environmental connectivity. It is found that humans are largely driven by institution structures, education, and social influence. In conclusion, more efforts should be placed to further analyze these structural incentives for pro-environmental behaviors and use them to make environmental stewardship more accessible for all people and diverse circumstances. This can be done by evaluating the human dimensions of what influences human attitudes and behaviors, how to use these forces to systematically influence pro-environmental choices, applying these structural forces to main conservation issues, and further incorporating moral discourse into the environmental research in order to appeal correctly to all aspects and perspectives. Only when human connectivity is understood in relation to the natural sciences will we be able to make positive change in the direction of a healthier Earth.
The FDA-approved drug bexarotene has been predominantly utilized for the treatment of cutaneous T-cell lymphoma (CTLC), but has shown promise as an off label treatment for various other cancers as well as Alzheimer's disease (AD). However, harmful side effects such as hypothyroidism have catalyzed a search for alternative rexinoids which retain similar levels of RXR agonism while reducing the undesirable effects incurred by bexarotene. This honors thesis outlines the steps taken to design and synthesize novel analogues of the selective retinoid-X-receptor (RXR) agonist 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). Corresponding NMR spectra indicates the successful construction of four novel compounds which are structurally similar to known, biologically-evaluated rexinoids that have induced fewer side effects while stimulating greater levels of RXR selectivity as compared to bexarotene. Future In vitro analyses of these four analogues coupled with the recognized efficacy of their parent compounds demonstrate the chemotherapeutic potential of structurally modified bexarotene analogues