ASU Scholarship Showcase

Illicit psychostimulant addiction remains a significant problem worldwide, despite decades of research into the neural underpinnings and various treatment approaches. The purpose of this review is to provide a succinct overview of the neurocircuitry involved in drug addiction, as well as the acute and chronic effects of cocaine and amphetamines within this circuitry in humans. Investigational pharmacological treatments for illicit psychostimulant addiction are also reviewed. Our current knowledge base clearly demonstrates that illicit psychostimulants produce lasting adaptive neural and behavioral changes that contribute to the progression and maintenance of addiction. However, attempts at generating pharmacological treatments for psychostimulant addiction have historically focused on intervening at the level of the acute effects of these drugs. The lack of approved pharmacological treatments for psychostimulant addiction highlights the need for new treatment strategies, especially those that prevent or ameliorate the adaptive neural, cognitive, and behavioral changes caused by chronic use of this class of illicit drugs.

Zeolitic Imidazolate Frameworks (ZIFs) are one of the potential candidates as highly conducting networks with surface area with a possibility to be used as catalyst support. In the present study, highly active state-of-the-art Pt-NCNTFs catalyst was synthesized by pyrolyzing ZIF-67 along with Pt precursor under flowing Ar-H₂ (90-10 %) gas at 700 °C. XRD analysis indicated the formation of Pt-Co alloy on the surface of the nanostructured catalyst support. The high resolution TEM examination showed the particle size range of 7 to 10 nm. Proton exchange membrane fuel cell performance was evaluated by fabricating membrane electrode assemblies using Nafion-212 electrolyte using H₂/O₂ gases (100 % RH) at various temperatures. The peak power density of 630 mW.cm² was obtained with Pt-NCNTFs cathode catalyst and commercial Pt/C anode catalyst at 70 °C at ambient pressure.

This paper studies the effect of targeted observations on state and parameter estimates determined with Kalman filter data assimilation (DA) techniques. We first provide an analytical result demonstrating that targeting observations within the Kalman filter for a linear model can significantly reduce state estimation error as opposed to fixed or randomly located observations. We next conduct observing system simulation experiments for a chaotic model of meteorological interest, where we demonstrate that the local ensemble transform Kalman filter (LETKF) with targeted observations based on largest ensemble variance is skillful in providing more accurate state estimates than the LETKF with randomly located observations. Additionally, we find that a hybrid ensemble Kalman filter parameter estimation method accurately updates model parameters within the targeted observation context to further improve state estimation.

The effects of urbanization on ozone levels have been widely investigated over cities primarily located in temperate and/or humid regions. In this study, nested WRF-Chem simulations with a finest grid resolution of 1 km are conducted to investigate ozone concentrations O₃ due to urbanization within cities in arid/semi-arid environments. First, a method based on a shape preserving Monotonic Cubic Interpolation (MCI) is developed and used to downscale anthropogenic emissions from the 4 km resolution 2005 National Emissions Inventory (NEI05) to the finest model resolution of 1 km. Using the rapidly expanding Phoenix metropolitan region as the area of focus, we demonstrate the proposed MCI method achieves ozone simulation results with appreciably improved correspondence to observations relative to the default interpolation method of the WRF-Chem system. Next, two additional sets of experiments are conducted, with the recommended MCI approach, to examine impacts of urbanization on ozone production: (1) the urban land cover is included (i.e., urbanization experiments) and, (2) the urban land cover is replaced with the region's native shrubland. Impacts due to the presence of the built environment on O₃ are highly heterogeneous across the metropolitan area. Increased near surface O₃ due to urbanization of 10–20 ppb is predominantly a nighttime phenomenon while simulated impacts during daytime are negligible. Urbanization narrows the daily O₃ range (by virtue of increasing nighttime minima), an impact largely due to the region's urban heat island. Our results demonstrate the importance of the MCI method for accurate representation of the diurnal profile of ozone, and highlight its utility for high-resolution air quality simulations for urban areas.

Attention deficit/hyperactivity disorder (ADHD) is a risk factor for tobacco use and dependence. This study examines the responsiveness to nicotine of an adolescent model of ADHD, the spontaneously hypertensive rat (SHR). The conditioned place preference (CPP) procedure was used to assess nicotine-induced locomotion and conditioned reward in SHR and the Wistar Kyoto (WKY) control strain over a range of nicotine doses (0.0, 0.1, 0.3 and 0.6 mg/kg). Prior to conditioning, SHRs were more active and less biased toward one side of the CPP chamber than WKY rats. Following conditioning, SHRs developed CPP to the highest dose of nicotine (0.6 mg/kg), whereas WKYs did not develop CPP to any nicotine dose tested. During conditioning, SHRs displayed greater locomotor activity in the nicotine-paired compartment than in the saline-paired compartment across conditioning trials. SHRs that received nicotine (0.1, 0.3, 0.6 mg/kg) in the nicotine-paired compartment showed an increase in locomotor activity between conditioning trials. Nicotine did not significantly affect WKY locomotor activity. These findings suggest that the SHR strain is a suitable model for studying ADHD-related nicotine use and dependence, but highlights potential limitations of the WKY control strain and the CPP procedure for modeling ADHD-related nicotine reward.

Positive allosteric modulators (PAMs) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are a diverse class of compounds that increase fast excitatory transmission in the brain. AMPA PAMs have been shown to facilitate long-term potentiation, strengthen communication between various cortical and subcortical regions, and some of these compounds increase the production and release of brain-derived neurotrophic factor (BDNF) in an activity-dependent manner. Through these mechanisms, AMPA PAMs have shown promise as broad spectrum pharmacotherapeutics in preclinical and clinical studies for various neurodegenerative and psychiatric disorders. In recent years, a small collection of preclinical animal studies has also shown that AMPA PAMs may have potential as pharmacotherapeutic adjuncts to extinction-based or cue-exposure therapies for the treatment of drug addiction. The present paper will review this preclinical literature, discuss novel data collected in our laboratory, and recommend future research directions for the possible development of AMPA PAMs as anti-addiction medications.

Research has shown that construction projects in Saudi Arabia have exhibited poor performance for the past three decades. The traditional risk management practices have been ineffective at helping contractors deliver projects on time and within budget while meeting quality expectations. Studies have identified that client decision making is one of the main causes of risks that occur on projects in Saudi Arabia. This paper proposes a new risk management model that can minimize client decision making, and enable the client to utilize expertise, thereby improving project quality and performance. The model is derived from the Information Measurement Theory (IMT) and Performance Information Procurement System (PIPS), both developed at Arizona State University in the United States (U.S.). The model has been tested over 1800 times in both construction and non-construction projects, showing a decrease in required management by owner by up to 80% and an increase in efficiency up to 40%.

A typical building construction process runs through three main consecutive phases: design, construction and operation. Currently, architects and engineers both engage in the creation of environmental designs that adequately reflect high performance through sustainability and energy efficiency in new buildings. Occupants of buildings have also recently demonstrated a dramatic increase in awareness regarding building operation, energy usage, and indoor air quality. The process of building construction is chronologically located between both the design and the operation phases. However, this phase has not yet been addressed in either understanding contractor behavior or developing innovative sustainable techniques. These two vital aspects have the potential to levy a dramatic impact on enhancing building performance and operational costs.

Repeatedly causing apprehension to the construction industry is a question that posits, “Why is there a gap/delta/inconsistency between the designed EUI, Energy Use Intensity, and the operational EUI”? Building occupants shall not be the only party that bears blame for the delta in energy. It is true, nonetheless, that occupants are part of the reason, but the contractor – as well as the entire construction phase - also remain prime suspects worth investigating. In the present time, research is predominantly focused on occupants (post-occupancy) and designers to educate and control the gap between designed and operational EUI. This research has succeeded in the identification of the construction phase, in conjunction with contractor behavior, as another main factor for initiating this energy gap. Therefore, not only is the coupling of sustainable strategies to the construction drivers crucial to attaining a sustainable project, but also it is integral to analyzing contractor behavior within each of the construction phases that play a vital role in successfully serving sustainability. Various techniques and approaches will assist contractors in amending their method statements to ensure a sustainable project.

This research correlates an existing project to the two proposed sustainable concepts: 1) Identify cost-saving strategies that may have been implemented or avoided during the construction process, and 2) Evaluate the impacts of implementing these strategies on overall performance. The adopted contexts are to partially foster sustainable architecture concepts to the Contractor process, and then proceed to analyze its cost implication on overall project performance. Results of the validation of this approach verify that when contractors embrace a sustainable construction process the overall project will yield various financial savings. A mixed-use project was utilized to validate these concepts, which indicated three outcomes: firstly, a 25% decrease in manpower for tiling while maintaining the same productivity, thus reflecting a saving of $3,500; next, increasing the productivity of concrete activity, which would shorten the duration of the construction by 45 days and reflect a saving of $1.5 million, and last of all, reducing the overhead costs of labor camps by efficiently orienting temporary shelters, which reveals a reduction in cooling and heating that returned a saving of approximately $10,000. This research develops a comprehensive evidence-based study that addresses the above-mentioned gap in the construction phase, which targets to yield a multi-dimensional tool that will allow: 1) integrating critical thinking and decision-making approaches regarding contractor behavior, and 2) adopting innovative sustainable construction methods that reflect reduction in operating costs.

The estimation of energy demand (by power plants) has traditionally relied on historical energy use data for the region(s) that a plant produces for. Regression analysis, artificial neural network and Bayesian theory are the most common approaches for analysing these data. Such data and techniques do not generate reliable results. Consequently, excess energy has to be generated to prevent blackout; causes for energy surge are not easily determined; and potential energy use reduction from energy efficiency solutions is usually not translated into actual energy use reduction. The paper highlights the weaknesses of traditional techniques, and lays out a framework to improve the prediction of energy demand by combining energy use models of equipment, physical systems and buildings, with the proposed data mining algorithms for reverse engineering. The research team first analyses data samples from large complex energy data, and then, presents a set of computationally efficient data mining algorithms for reverse engineering. In order to develop a structural system model for reverse engineering, two focus groups are developed that has direct relation with cause and effect variables. The research findings of this paper includes testing out different sets of reverse engineering algorithms, understand their output patterns and modify algorithms to elevate accuracy of the outputs.

Brazil has had issues in efficiently providing the required amount of electricity to its citizens at a low cost. One of the main causes to the decreasing performance of energy is due to reoccurring droughts that decrease the power generated by hydroelectric facilities. To compensate for the decrease, Brazil brought into use thermal power plants. The power plants being on average 23.7% more expensive than hydroelectric. Wind energy is potentially an alternative source of energy to compensate for the energy decrease during droughts. Brazil has invested in wind farms recently, but, due to issues with the delivery method, only 34% of wind farms are operational. This paper reviews the potential benefit Brazil could receive from investing more resources into developing and operating wind farms. It also proposes that utilization of the best value approach in delivering wind farms could produce operational wind farms quicker and more efficiently than previously experienced.