ASU Scholarship Showcase

Green infrastructure serves as a critical no-regret strategy to address climate change mitigation and adaptation in climate action plans. Climate justice refers to the distribution of climate change-induced environmental hazards (e.g., increased frequency and intensity of floods) among socially vulnerable groups. Yet no index has addressed both climate justice and green infrastructure planning jointly in the USA. This paper proposes a spatial climate justice and green infrastructure assessment framework to understand social-ecological vulnerability under the impacts of climate change. The Climate Justice Index ranks places based on their exposure to climate change-induced flooding, and water contamination aggravated by floods, through hydrological modelling, GIS spatial analysis and statistical methodologies. The Green Infrastructure Index ranks access to biophysical adaptive capacity for climate change. A case study for the Huron River watershed in Michigan, USA, illustrates that climate justice hotspots are concentrated in large cities; yet these communities have the least access to green infrastructure. This study demonstrates the value of using GIS to assess the spatial distribution of climate justice in green infrastructure planning and thereby to prioritize infrastructure investment while addressing equity in climate change adaptation.

Background: Cysteine sulfenic acid (Cys-SOH) plays important roles in the redox regulation of numerous proteins. As a relatively unstable posttranslational protein modification it is difficult to quantify the degree to which any particular protein is modified by Cys-SOH within a complex biological environment. The goal of these studies was to move a step beyond detection and into the relative quantification of Cys-SOH within specific proteins found in a complex biological setting--namely, human plasma.

Results: This report describes the possibilities and limitations of performing such analyses based on the use of thionitrobenzoic acid and dimedone-based probes which are commonly employed to trap Cys-SOH. Results obtained by electrospray ionization-based mass spectrometric immunoassay reveal the optimal type of probe for such analyses as well as the reproducible relative quantification of Cys-SOH within albumin and transthyretin extracted from human plasma--the latter as a protein previously unknown to be modified by Cys-SOH.

Conclusions: The relative quantification of Cys-SOH within specific proteins in a complex biological setting can be accomplished, but several analytical precautions related to trapping, detecting, and quantifying Cys-SOH must be taken into account prior to pursuing its study in such matrices.