Matching Items (3)
Description
In this paper, I analyze the costs and benefits of waste prevention and zero waste initiatives that are inflicted upon society. The problem lies in the amount of human municipal solid waste (HMSW) resulting from human activities, especially as growing global urban population estimated to be producing three times as much waste as it does today (Goto, 2014). Landfill externalities are addressed to explain the purpose of this research. Additionally, the efficiency of diverting waste from the landfill is assessed; these diversion methods are recycling, composting, and the uses of TerraCycle. It is important to note the difference between waste prevention and zero waste: Waste prevention is simply reducing the amount of waste, whereas zero waste is aiming to divert HMSW for other uses other than going its final destination, the landfill. This research highlights tax policies and incentive-based approaches that cities currently enforce, as well as repercussions of these approaches. Waste prevention is explored from the user perspective and reactions to taxes on waste that were implemented to promote global sustainability, which can be seen from the primary data collected. I analyze the success of zero waste initiatives in the online marketing agency, Vertical Measures, comparing landfill waste diversion with the implementation of zero waste initiatives. This paper highlights the observations and results from this two-month analysis. With both the analyses of city regulations and first-hand application of zero waste and waste prevention methods, the findings suggest that the success of these initiatives depends on various factors including location and participant attitudes. This research and data can help provide insight for other small businesses for a more sustainable environment and workplace.
ContributorsPhong, Kellie Hue (Author) / Williams, Stanley N. (Thesis director) / Abbott, Joshua K. (Committee member) / Slaymaker, Alexandra (Committee member) / W. P. Carey School of Business (Contributor) / Department of Marketing (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Transient receptor potential (TRP) channels are a diverse family of polymodally gated nonselective cation channels implicated in a variety of pathophysiologies. Two channels of specific interest are transient receptor potential melastatin 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1).
TRPM8 is the primary cold sensor in humans and is activated by ligands that feel cool such as menthol and icilin. It is implicated to be involved in a variety of cancers, nociception, obesity, addiction, and thermosensitivity. There are thought to be conserved regions of structural and functional importance to the channel which can be identified by looking at the evolution of TRPM8 over time. Along with this, looking at different isoforms of TRPM8 which are structurally very different but functionally similar can help isolate regions of functional interest as well. Between TRP channels, the transmembrane domain is well conserved and thought to be important for sensory physiology. To learn about these aspects of TRPM8, three evolutionary constructs, the last common primate, the last common mammalian, and the last common vertebrate ancestor TRPM8 were cloned and subjected to preliminary studies. In addition to the initial ancestral TRPM8 studies, fundamental studies were initiated in method development to evaluate the use of biological signaling sequences to attempt to force non-trafficking membrane protein isoforms and biophysical constructs to the plasma membrane. To increase readout for these and other studies, a cellular based fluorescence assay was initiated. Eventual completion of these efforts will lead to better understanding of the mechanism that underlie TRPM8 function and provide enhanced general methods for ion channel studies.
Beyond TRPM8 studies, an experiment was designed to probe mechanistic features of TRPV1 ligand activation. TRPV1 is also a thermosensitive channel in the TRP family, sensing heat and vanilloid ligands like capsaicin, commonly found in chili peppers. This channel is also involved in many proinflammatory interactions and associated with cancers, nociception, and addiction. Better understanding binding interactions can lead to attempts to create therapeutics.
TRPM8 is the primary cold sensor in humans and is activated by ligands that feel cool such as menthol and icilin. It is implicated to be involved in a variety of cancers, nociception, obesity, addiction, and thermosensitivity. There are thought to be conserved regions of structural and functional importance to the channel which can be identified by looking at the evolution of TRPM8 over time. Along with this, looking at different isoforms of TRPM8 which are structurally very different but functionally similar can help isolate regions of functional interest as well. Between TRP channels, the transmembrane domain is well conserved and thought to be important for sensory physiology. To learn about these aspects of TRPM8, three evolutionary constructs, the last common primate, the last common mammalian, and the last common vertebrate ancestor TRPM8 were cloned and subjected to preliminary studies. In addition to the initial ancestral TRPM8 studies, fundamental studies were initiated in method development to evaluate the use of biological signaling sequences to attempt to force non-trafficking membrane protein isoforms and biophysical constructs to the plasma membrane. To increase readout for these and other studies, a cellular based fluorescence assay was initiated. Eventual completion of these efforts will lead to better understanding of the mechanism that underlie TRPM8 function and provide enhanced general methods for ion channel studies.
Beyond TRPM8 studies, an experiment was designed to probe mechanistic features of TRPV1 ligand activation. TRPV1 is also a thermosensitive channel in the TRP family, sensing heat and vanilloid ligands like capsaicin, commonly found in chili peppers. This channel is also involved in many proinflammatory interactions and associated with cancers, nociception, and addiction. Better understanding binding interactions can lead to attempts to create therapeutics.
ContributorsShah, Karan (Author) / Van Horn, Wade (Thesis director) / Neisewander, Janet (Committee member) / Biegasiewicz, Kyle (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / School of Molecular Sciences (Contributor, Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Global climate models predict increases in precipitation events in the Phoenix-metropolitan area and with the proposition of more flooding new insights are needed for protecting roadways and the services they provide. Students from engineering, sustainability, and planning worked together in ASU’s Urban Infrastructure Anatomy Spring 2016 course to assess:
1. How historical floods changed roadway designs.
2. Precipitation forecasts to mid-century.
3. The vulnerability of roadways to more frequent precipitation.
4. Adaptation strategies focusing on safe-to-fail thinking.
5. Strategies for overcoming institutional barriers to enable transitions.
The students designed an EPA Storm Water Management Model for the City of Phoenix and forced it with future precipitation forecasts. Vulnerability indexes were created for infrastructure performance and social outcomes. A multi-criteria decision analysis framework was created to prioritize infrastructure adaptation strategies.
ContributorsChester, Mikhail Vin (Author) / Al Rasbi, Omar (Author) / Archer, Harold (Author) / Azizi, Tariq Aziz (Author) / Bondank, Emily (Author) / Caccavale, Raymond (Author) / Eisenberg, Daniel (Author) / Elzomor, Mohamed (Author) / Gorman, Brandon (Author) / Kim, Yeoman (Author) / Klass, Morgan (Author) / Koride, Siddartha (Author) / Krantz, David (Author) / Langlois, Cody (Author) / Mishra, Adyasha (Author) / Musili, Catherine (Author) / Muvva, Vijay (Author) / Nassar, Carra (Author) / Nihal Rao, Chepyala (Author) / Parikh, Among (Author) / Quintans, Christiane (Author) / Santiago, Rebecca (Author) / Schattnick, Kelsey (Author) / Shah, Karan (Author) / Shinn, Allison (Author) / Sifferman, Steven (Author) / Slaymaker, Alexandra (Author) / Soneji, Parth (Author) / Taege, Leslie (Author) / Thomas, Christopher (Author) / Velez, Daniel (Author) / Wang, Kezhen (Author) / Zhang, Xiao (Author) / Arizona State University. School of Sustainable Engineering and the Built Environment (Contributor) / Arizona State University. Center for Earth Systems Engineering and Management (Contributor)