The primary goal of this study is to assess and develop an understanding of the effects of Assisted Cycling Therapy on manual motor performance in children with Down syndrome. Seven children (Mage 11.6 years old) completed a 30-minute cycle session 2x/week for 8 weeks on the PACT bicycle at a 35% greater rate than their self-selected rate. Pre- and post-testing of grip force with a dynamometer and unimanual and bimanual manual dexterity using the Purdue Pegboard were measured to determine changes in force production and fine motor control, respectively. Results consistently showed improvements in grip force in both hands and bimanual dexterity following PACT. My results are interpreted with respect to cerebral lateralization and neuroplasticity following PACT intervention.