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Description
Glucocorticoids are a class of corticosteroids that bind to glucocorticoid receptors
within cells that result in changes in the metabolism of carbohydrates and immune functions.
Ingesting glucocorticoids has also been linked to insulin resistance, a main feature of Type 2
diabetes. Experiments including polymerase chain reaction, western blotting, and glycogen
synthase analysis were conducted to determine if exposure to higher doses of dexamethasone, a
glucocorticoid, induces insulin resistance in cultured rat skeletal muscle via interaction with
thioredoxin-interacting protein (TXNIP). Treatment with dexamethasone was shown to cause
mild increases in TXNIP while a definitive increase or decrease in insulin signaling was unable
to be determined.
within cells that result in changes in the metabolism of carbohydrates and immune functions.
Ingesting glucocorticoids has also been linked to insulin resistance, a main feature of Type 2
diabetes. Experiments including polymerase chain reaction, western blotting, and glycogen
synthase analysis were conducted to determine if exposure to higher doses of dexamethasone, a
glucocorticoid, induces insulin resistance in cultured rat skeletal muscle via interaction with
thioredoxin-interacting protein (TXNIP). Treatment with dexamethasone was shown to cause
mild increases in TXNIP while a definitive increase or decrease in insulin signaling was unable
to be determined.
ContributorsCusimano, Jason A (Author) / Sweazea, Karen (Thesis director) / Reaven, Peter (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
ContributorsMarine Biological Laboratory Archives (Publisher) / Arizona Board of Regents (Publisher)
Created1935
ContributorsHuettner, Alfred F. (Alfred Francis), b. 1884 (Creator) / Marine Biological Laboratory Archives (Publisher)
Created1918
ContributorsMarine Biological Laboratory Archives (Publisher)
ContributorsHuettner, Alfred F. (Alfred Francis), b. 1884 (Creator) / Marine Biological Laboratory Archives (Publisher)
Created1928
ContributorsHuettner, Alfred F. (Alfred Francis), b. 1884 (Creator) / Marine Biological Laboratory Archives (Publisher)
Created1918
ContributorsHuettner, Alfred F. (Alfred Francis), b. 1884 (Creator) / Marine Biological Laboratory Archives (Publisher)
ContributorsHuettner, Alfred F. (Alfred Francis), b. 1884 (Creator) / Marine Biological Laboratory Archives (Publisher)
ContributorsHuettner, Alfred F. (Alfred Francis), b. 1884 (Creator) / Marine Biological Laboratory Archives (Publisher)
ContributorsHuettner, Alfred F. (Alfred Francis), b. 1884 (Creator) / Marine Biological Laboratory Archives (Publisher)
Created1922