Matching Items (36)
Description
Skin cancer diagnoses and deaths continue to increase every year. With basal cell carcinoma (BCC) being the most common type of skin cancer diagnoses, establishing protective measurements against it are important. Surprisingly, sunscreen may not be as effective at protecting against basal cell carcinoma as it is for another non-melanoma type of skin cancer: squamous cell carcinoma. This paper aims to identify some differences between the two non-melanoma type cancers to find probable reasons sunscreen may be more effective at protecting against one over the other, as well as to find new solutions to protect against basal cell carcinoma. The results conclude that basal cell carcinoma does have UV-induced pathogenesis, in which case sunscreen is protective; however, it also revealed the need for ingredient studies and more sunscreen efficacy studies to determine other BCC pathogenesis pathways. Lastly, aided by dermatologist interviews, current interventions were established in order to provide greater protection against skin cancer. These include reforming the way commercials portray sunscreen to better educate the public about proper application and re-application, genetic testing for high-risk BCC markers, and an emphasis on sun education to the mothers of children.
ContributorsBozzano, Bianca (Author) / Washo-Krupps, Delon (Thesis director) / Hendrickson, Kirstin (Committee member) / Hicks, Andrew (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
There has been an alarming rise in the prevalence of obesity which has been attributed to the paralleled rise in consumption of high-fat foods. It’s commonly accepted that high-fat diets can lead to increased weight gain, however not all fats have the same physiological action. This study primarily focuses on the effect of canola oil, a monounsaturated fat, on energy homeostasis and body composition when it’s given as a supplement to a high-fat diet composed of saturated fatty acid. Rodent models were divided into three dietary groups: 1) low-fat diet (LFD), 2) high-fat diet (HFD) and 3) canola oils supplemented HFD (HF+CAN). After 4 weeks of dietary intervention, samples of epididymal fat, perinephric fat, and liver were analyzed across the three groups to see if the changes in energy homeostasis could be explained by the cellular behavior and composition of these tissues. Interestingly, the supplement of canola oil appeared to reverse the deleterious effects of a saturated fat diet, reverting energy intake, body weight gain and adipose tissue sizes to that (if not lower than that) of the LFD group. The only exception to this effect was the liver: the livers remained larger and fattier than those of the HFD. This occurrence is possibly due to a decrease in free fatty acid uptake in the adipose tissues—resulting in smaller adipose tissue sizes—and increased fatty acid uptake in the liver. The mechanism by which this occurs has yet to be elucidated and will be the primary focus of upcoming studies on the effect of monounsaturated fat on other diets.
ContributorsZuo, Connie Wanda (Author) / Washo-Krupps, Delon (Thesis director) / Deviche, Pierre (Committee member) / Herman, Richard (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
Many stressors today are psychological rather than physical and are influenced by the brain's perception of the stressor. The peripartum period is a particularly volatile time that is susceptible to new and stronger stressors. This current study investigates the relationship between self-reported perceived stress levels and physiological cortisol reactivity levels in new mothers at the 12-week postpartum time point. In addition, it examines the relationship between the mother and infants' physiological cortisol reactivity levels at 12-weeks postpartum. This current study is part of a longitudinal study and assessed these two correlations for 181 mother-infant dyads from a low income Mexican American population. The self-reported stress levels were assessed using the 4-item Perceived Stress Scale (PSS) and the cortisol reactivity data was gathered using four salivary cortisol samples taken from both mother and infant surrounding 5 interaction tasks and analyzed using Area Under the Curve with respect to ground (AUCg). Unexpectedly, the results found no correlation between perceived and physiological stress levels in the mothers, with a Pearson correlation of 0.114 and a p-value of 0.129. However, there was a positive correlation between mother and infant cortisol reactivity, with a correlation of 0.632 and a p-value less than 0.0001. This early postpartum period plays a significant role in developing HPA axis regulation for infants and developing productive mother-infant interactions. The physiological and psychological risks of chronically elevated stress for both mothers and children were addressed in this study as well, with implications for means to address and mitigate potential cortisol dysregulation.
ContributorsRegan, Emily Nicole (Author) / Washo-Krupps, Delon (Thesis director) / Crnic, Keith (Committee member) / Hanna, Mariam (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
In the United States, a dispute has arisen over the safety and need for vaccination, particularly in regard to compulsory vaccination laws. New outlets and social media sites publish countless reports about the dangers of vaccines or of known adverse reactions as well as imagined or unproven worries. Individuals' rights to choose to get vaccinated or allow their children to be vaccinated comes to direct conflict with measures needed to protect communities from preventable viral diseases. The controversy surrounding vaccines is not new, nor necessarily are the fundamental reasons for skepticism. Looking back through the history of vaccines as a medical tool, the evolution of the controversy can be observed taking place with each new historical context, scientific development, and social conditions. Despite scientific research and assurances of vaccine safety, opposition and unease about vaccination appear to take Looking individually at the development and distribution of the smallpox (variola virus), polio (poliovirus) and human papilloma virus(HPV) vaccines, concerns regarding the violation of personal rights, safety of vaccines themselves, and social stigmas and connotations surrounding vaccines can be seen to evolve and change. Due to the way doubt can manifest in different ways over time, it may be impossible to fully end the vaccine debate. However, nderstanding the sociological factors behind anti-vaccine sentiment may allow healthcare professionals to work with concerned people with a particular care to address these visceral and sometimes irrational fears surrounding vaccination.
ContributorsStevens, Luke Christian (Author) / Jacobs, Bertram (Thesis director) / Washo-Krupps, Delon (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Life Sciences (Contributor)
Created2014-05
DescriptionBest Behaviors is a non-profit organization aimed at reducing euthanasia rates and increasing adoption rates at county shelters. The program focuses on the use of positive reinforcement training and an educating the public about responsible pet ownership.
ContributorsWingler, Victoria Kay (Author) / Washo-Krupps, Delon (Thesis director) / Risley-Curtiss, Christina (Committee member) / Mars, Matthew (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
Abstract The purpose of this study was to discover the most prominent factors that affect the Arizona population from routinely visiting the dentist. For many people there is a factor of anxiety or fear, while others have issues with cost, insurance, or even the dental clinic environment. My study looks at some of these factors and supports the data with available research on dental avoidance factors. A significant portion of the study is also allotted to potential solutions to these avoidance factors, in order to increase regular dental visitation. Oral health is extremely important not only to the teeth, but also to the rest of the body. Therefore, it is important to address avoidance factors and find potential solutions to these problems. The study involved 71 participants, eighteen years of age or older, and a questionnaire with twenty-one questions. These questions asked the participants about gender, ethnicity, age, employment, reasons for avoidance, oral health education, and past dental experiences. These questions were designed to better understand how a person's background and understanding of dentistry affect their decision to visit the dentist. These questions also provide insight to why certain avoidance factors apply to different groups of people in the Arizona population. The results of the study showed that anxiety, price, insurance issues, and the personality of the dentist are the most prominent factors that cause individuals to avoid the dentist. Potential solutions to these avoidance factors were given, especially for anxious individuals. There are dentists who deal specifically with anxious individuals through sedation dentistry. Regarding price, there were several options for free or low-cost dental clinics that were provided. Preventative dentistry education was an important focus and solution to many of the avoidance factors, because when individuals are more aware of how to care for their teeth, there is a greater chance that they will have healthier teeth and dental visits will be less invasive and costly. Suggestions were provided for spreading oral health education and preventative dentistry through community programs and schools. Among the avoidance factors addressed, solutions provided, and the importance of oral health and preventative dentistry reiterated, the study stressed the importance of the results to my future profession. As a future dental practitioner, the data and research will be used in order for me to become a more compassionate and accommodating practitioner to my future patients. There is a special relationship and trust between the dental practitioner and their patient, and this study has helped me better understand how to accommodate patients and eliminate the factors that cause them to avoid regular dental visits.
ContributorsValimaki, Casey Jordyn (Author) / Washo-Krupps, Delon (Thesis director) / Bang, Christofer (Committee member) / Schoenborn, Scot (Committee member) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
My thesis consisted of both a self-directed study and a creative project. I worked with Dr. Michael Grabow, an endodontist of 20 years, to understand the scientific and technical aspects of root canal therapy. The first phase of the thesis was a review of dental biology, tooth development, morphology, physiology, radiology, and endodontics. The second phase was the creative project in which I learned the technical process of performing a root canal. In this phase, I observed Dr. Grabow execute root canal therapy on live patients and extracted teeth (obtained from an oral surgeon). I then completed root canals of my own on extracted teeth, under the instruction and oversight of Dr. Grabow.
ContributorsGrabow, Maiti Siobhan (Author) / Washo-Krupps, Delon (Thesis director) / Ugarova, Tatiana (Committee member) / Sick, Todd (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
DescriptionThe paper intends to look at the issues surrounding trauma center proliferation, cost, and the worries of cascading failure.
ContributorsOcal, Jon (Author) / Douglas, Kacey (Thesis director) / Foster, William (Committee member) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The esports scene has been constantly evolving ever since its inception in the early 1970s, growing from small arcade based tournaments to the multibillion dollar industry that can be observed today (Bountie Gaming, 2018). In fact, the term esports was not widely used until the early 2000s, decades after the first gaming tournaments had taken place. Decades prior, the earliest large-scale gaming tournament was hosted by Atari in 1980 for the game Space Invaders . While still primitive by today’s standards, games such as Space Invaders inspired fierce competition and effectively laid the foundation for what would grow into the booming industry that we see today (Edwards, 2013).
ContributorsCollins, Neil Andrew (Author) / Mendez, Jose (Thesis director) / Foster, William (Thesis director) / Pierce, John (Committee member) / Department of Economics (Contributor) / WPC Graduate Programs (Contributor) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Regenerative medicine is a relatively new area of interest among researchers and physicians alike and has truly come to light within the last twenty years. Its purpose is to “regenerate” cells in our body to return tissue and organs systems to their normal functions by utilizing innate cell mechanisms. Uses have ranged from growing completely new body tissue in labs, to promoting the repair of damaged neurons. More recently, the use of regenerative medicine techniques such as stem cell and platelet rich plasma therapy has seen significant growth throughout high level and professional sports. Beginning in the early 2000s, treatments quickly gained popularity as professional athletes began using them as an alternative to surgery, but this came before any concrete scientific support. This thesis paper will analyze the current statistical data supporting the use of platelet rich plasma and stem cell therapy and associated regulations to describe the connection between regenerative medicine and sports.
ContributorsFritzke, Jack Teodor (Author) / Washo-Krupps, Delon (Thesis director) / Foster, William (Committee member) / Levinson, Simin (Committee member) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05