The Lord of the Rings films are an immensely popular early 2000s film trilogy. Yet the films’ popularity goes deeper than critical acclaim. The films have a cult following, enough for the films to have frequent theatrical re-releases and for Hollywood to begin producing more Lord of the Rings content starting in 2022 with Amazon’s Rings of Power. Why do these films, the first live-actions adaptations of Tolkien’s books, have such long-lasting appeal? Academic scholars have thoroughly attempted to answer this question. Some scholars have even utilized the theories of Carl Jung—including his theory of archetypes—to explain the purpose of certain characters within the films. Few, however, have utilized Jung’s theory of archetypes in great depth alongside his theory of the collective unconscious. This piece attempts to supplement the works of previous scholars in explaining the Lord of the Rings films’ appeal by emphasizing subconscious appeal, utilizing the theories of Carl Jung. Specifically, this piece analyzes the characters of Gollum as a portrayal of the shadow archetype, and the characters of Aragorn and Arwen as the anima and animus archetypes respectively. Further, this piece argues that Jung’s theory of the collective unconscious in humans not only be applied to the portrayal of the race of men in the films, but also to the races of elves and orcs. Elves and orcs are shown to have similar but different collective unconsciouses which viewers can then subconsciously compare to the collective unconscious of men portrayed. This analysis serves to explain a number of subconscious appeals of the Lord of the Rings films which explain their immense and long-lasting popularity.

The purpose of this study is to explore birth order effects on personality and how they influence field of study, academic self-efficacy, and future self-identification. The research aims to replicate past findings on birth order and personality variation while further exploring how birth order affects field of study, academic self-efficacy, and future self-identification. Furthermore, the research study will examine if personality variation mediates the relationship between birth order and field of study, academic self-efficacy, and future self-identification. The research sample (N=90) was used to explore these concepts. Lastly, the research will investigate within families, if birth order predicts differences in personality, academic self-efficacy, and future self-identification using 13 sibling pair results. The researchers recruited participants to complete self-reports of birth order, variable measures, and demographics using a survey on Qualtrics survey software through social media channels during the Fall and Spring of 2022 - 2023. The study yielded very few implications for birth order and personality variation, and how they influence fields of study, academic self-efficacy, and future self-identification. Further exploration of birth order and personality as they relate to field of study, academic self-efficacy, and future self-identification is necessary as it may positively contribute to parental expectations, parent-child relationships, and parental understanding of differences of goals and interests among siblings. Furthermore, future studies should investigate factors that may change birth order effects on personality such as evolving social standards, family size, and culture shifts.

Pelvic organ prolapse (POP) is a condition involving the weakening of the pelvic floor, with a prevalence of up to 50% of women experiencing the condition to some degree. Individuals with the condition are susceptible to multiple symptoms include vaginal protrusion, dyspareunia, and difficulties with waste excretion. Risk factors are common and numerous for POP, and the economic burden of the condition poses a significant cost to nations worldwide. For many years, the primary solution to POP was the usage of transvaginal meshes, often composed of polypropylene, but rising reports of harmful side effects have led to their recall. Due to this, the space is open for novel solutions, and treatments based in regenerative medicine are on the rise. One such potential treatment is the usage of functionalized polyvinyl alcohol scaffolds to support the regeneration and strengthening of the pelvic floor. To validate the usage of this scaffold, this study focuses on the biocompatibility of the scaffolds, with specific focus on the maintenance of cell viability and proliferation on the scaffold. Through usage of metabolic assays and fluorescence microscopy, scaffolds composed of functional polyvinyl alcohol with cellulose have shown promise in supporting the cell types necessary for reconstructing the pelvic floor.

In journalism school, reporters learn to be unbiased, impartial and objective when covering a story. They are to stay neutral and detached from their reporting. However, this standard has become unrealistic and unachievable for many journalists. "Inside Objectivity" is a five-episode podcast that focuses on what journalistic objectivity looks like in the 21st century. In this podcast, you will hear from journalists, scholars, historians, researchers and a news consumer. These guests will provide their thoughts regarding journalistic objectivity and whether this ethical standard needs to be modified. To listen to the episodes and learn more about the podcast, visit insideobjectivity.com.

The ERK1/2 cell signaling pathway is highly conserved and a prominent regulator of processes like cell proliferation, differentiation, and survival. During nervous system development, the ERK1/2 cascade is activated by the binding of growth factors to receptor tyrosine kinases, leading to the sequential phosphorylation of intracellular protein kinases in the pathway and eventually ERK1 and ERK2, the effectors of the pathway. Well-defined germline mutations resulting in hyperactive ERK1/2 signaling have been implicated in a group of neurodevelopmental disorders called RASopathies. RASopathic individuals often display features such as developmental delay, intellectual disability, cardio-facial abnormalities, and motor deficits. In addition, loss-of-function in ERK1/2 can lead to neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability. To better understand the pathology of these neurodevelopmental disorders, the role of ERK1/2 must be examined during the development of specific neuronal and glial subtypes. In this study, we bred transgenic mice with conditional deletion of ERK1/2 in cholinergic neuronal populations to investigate whether ERK1/2 mediates the survival or activity of basal forebrain and striatal cholinergic neurons during postnatal development. By postnatal day 10, we found that ERK1/2 did not seem to mediate cholinergic neuron number within the basal forebrain or striatum. In addition, we showed that expression of FosB, a neuronal activity-dependent transcription factor and target of ERK1/2, was not yet observed in cholinergic neurons within either of these anatomical regions by P10. Finally, our preliminary data suggested that FosB expression within layer IV of the somatosensory cortex, a target domain for basal forebrain cholinergic projections, also did not appear to be mediated by ERK1/2 signaling. However, since cholinergic neuron development is not yet complete by P10, future work should explore whether ERK1/2 plays any role in the long-term survival and function of basal forebrain and striatal cholinergic neurons in adulthood. This will hopefully provide more insight into the pathology of neurodevelopmental disorders and inform future therapeutic strategies.

An autoimmune disease is a health condition in which the immune system attacks your body due to the inability to differentiate between foreign cells and your own cells. There are over 80 autoimmune diseases that affect the human body, but we specifically want to focus on three diseases: Crohn’s Disease, Rheumatoid Arthritis (RA), and Multiple Sclerosis (MS). These three autoimmune diseases affect young adults the most and impact three integral parts of the body – the GI tract, musculoskeletal system, and the central nervous system, respectively. We would like to further research how nutrition and diet can affect individuals with these autoimmune disorders. We want to better understand the role diet plays in maintaining both the physical and mental health condition of an individual with an autoimmune disease. Stress has been hypothesized to be a factor in the triggering of an autoimmune disease and we have noticed how stress can be a major factor on a person’s daily food choices and intake. We are also interested in how we can incorporate this knowledge of the benefits of nutrition into routine patient care. Within the healthcare setting, we have both witnessed first-hand how patients were able to improve as well as maintain their physical health condition via their diet. For example, through an appropriate diet, patients were able to show improvements in their lab work and/or maintain and prevent health conditions such as autoimmune disorders. Therefore, we would like to better understand how diet can control and/or manage autoimmune disorders.

Chronic pain, or reoccurring pain lasting longer than three months, is frequently co- morbid with other chronic conditions. Physiological health problems such as overall general health, immune function, inflammation, stress, and sleep, as well as psychological problems like depression and anxiety are all associated with chronic pain. Previous studies have also shown evidence for the heritability of chronic pain, indicating a genetic factor for chronic pain in children. However, few studies have investigated potential epigenetic processes involved in childhood chronic pain. DNA methylation and other epigenetic processes are highly susceptible to changes during crucial developmental periods in children, and they are heavily influenced by psychosocial factors and environmental factors. During an immune response, various cytokines such as TNFα, IL-6, and CRP are released. Cytokines are involved in the production of pain through their pro-inflammatory properties. Additionally, there is evidence to believe they increase pain sensitivity acutely by acting directly on nociceptors. Previous studies have shown that higher levels of inflammatory cytokines are associated with more pain because the inflammatory response from our immune cells activates pain pathways. A constant or prolonged activation of the immune response may consequently result in chronic pain. In many cases of chronic pain, there is an increase in the circulating pro-inflammatory cytokines in the blood that also leads to hypersensitivity.