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- Creators: Barrett, The Honors College
Description
Glioblastoma multiforme is associated with a very low survival rate and is recognized as the most vicious form of intracranial cancer. The Akt gene pathway has three different isoforms, each of which has a different role in the tumors of GBM. Preliminary data suggests that Akt3 may work to decrease tumorigenicity. A produced image that visualizes the subcellular localization of Akt3 led the author to believe that Akt3 may reduce tumorigenicity by decreasing genomic instability caused by the cancer. To explore this, flow cytometry was performed on GBM cell lines with Akt3v1 over-expression, Akt3v2 over-expression, and a control glioma cell line.
ContributorsGhorayeb, Antoine (Author) / Neisewander, Janet (Thesis director) / Diehnelt, Chris (Committee member) / Moussallem, Suzan (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
ContributorsFishman, Jacob (Author) / DeSerpa, Allan (Thesis director) / Hill, John (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor)
Created2012-12
Description
The lonely, empty face panhandling on the street corner has a story to tell. At first glance, most people write the homeless off as less than worthy. However, there is a deeper connection and understanding of relationships and a sense of community unseen by the majority of passer-byers. Amidst the humdrum beat of every day life, there is toil to find basic necessities such as food, water, sanitation, and a place to rest. At the same time, there is laughter and friendship as they help one another through the hostilities of their circumstances. Combining the creative elements of photojournalism and qualitative interviewing, the basic daily needs and struggles of the homeless will be delved into to answer how friendship is pertinent to survival on the streets.
ContributorsFisher, Meghan (Author) / Hruschka, Daniel (Thesis director) / Hita, Liza (Committee member) / Newland, Judy (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
The purpose of my honors thesis project was to generate the tools needed for in vivo imaging by determining the optimal plasmid-fluorophore combination. To determine the optimal plasmid and fluorophore, asd plasmids were constructed with various promoters, origins of replications, and red fluorophores. The optimal asd plasmid for fluorescent in vivo imaging was determined by the plasmid stability, growth rate, and growth phase dependence on fluorescent intensity. The end goal is to be able to use the asd plasmid in vaccine strains for the purpose of in vivo imaging of the recombinant attenuated Salmonella vaccine (RASV).
ContributorsEudy, L. Adam (Author) / Curtiss, Roy (Thesis director) / Roland, Kenneth (Committee member) / Forbes, Stephen (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Microfinance is a term that refers to providing basic financial services to the poor; it has become a powerful tool for poverty alleviation. The idea is a relatively new one - modern microfinance began through experiments in the 1970's - but it has grown quickly and currently serves over 155 million clients worldwide. There are many studies that provide evidence of the positive impact of microfinance and the movement has an array of enthusiastic proponents. It is certainly not the only solution in the battle against poverty, however, and there are also studies that question the true depth of its impact. In looking at microfinance around the globe, one thing becomes clear: although it is an international phenomenon, microfinance has definitely found more success in some regions over others.
ContributorsEdgell, Bailey (Author) / Mendez, Jose (Thesis director) / Schoellman, Todd (Committee member) / Forbes, Stephen (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Prospective memory is defined as remembering to carry out specified actions in the future. Research has suggested that prospective memory retrieval is reliant on multiple cognitive processes to function, and the ways in which these different processes are used is dependent on a variety of variables relating to the prospective memory task at hand. The current study focuses on the strength of the association between the prospective
memory cue and the prospective memory intention. Based on literature suggesting that aspects of prospective memory are reliant on executive control functioning, the current study examined the possibility that executive control depletion would affect prospective memory ability on subsequent tasks. Results showed that depletion of executive control resources, measured objectively, did not impair prospective memory in either a low or
high cue-association condition. However, participants‟ subjective assessment of their own fatigue correlated significantly with their subsequent prospective memory performance, regardless of association condition. The results of the study indicate that depletion studies that fail to account for both objective and subjective measures suffer from an unclear interpretation of effects, and that recognition of perceived expectancies
of cognitive resource limitation can assist in improving prospective memory ability.
memory cue and the prospective memory intention. Based on literature suggesting that aspects of prospective memory are reliant on executive control functioning, the current study examined the possibility that executive control depletion would affect prospective memory ability on subsequent tasks. Results showed that depletion of executive control resources, measured objectively, did not impair prospective memory in either a low or
high cue-association condition. However, participants‟ subjective assessment of their own fatigue correlated significantly with their subsequent prospective memory performance, regardless of association condition. The results of the study indicate that depletion studies that fail to account for both objective and subjective measures suffer from an unclear interpretation of effects, and that recognition of perceived expectancies
of cognitive resource limitation can assist in improving prospective memory ability.
ContributorsCook, Carson (Author) / Brewer, Gene (Thesis director) / Presson, Clark (Committee member) / Homa, Donald (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
ContributorsBingham, Tucker (Author) / Setlow, Jennifer (Thesis director) / Melo, Carla (Committee member) / Danowski, Christopher (Committee member) / Barrett, The Honors College (Contributor) / Herberger Institute for Design and the Arts (Contributor)
Created2012-12
Description
Social proof and mismatch of self-preference have been assumed to play an important role in the inference of value. They can be influential factors when it comes to decision-making in a mate-selection environment. In this thesis study, participants took an online survey in the form of a dating website. They answered a series of questions about the traits they would like to see in a potential mate. They were then presented with four potential mates and asked to rank them by their preferences. The results show that participants most preferred the potential mate with a high social proof and a low mismatch of self-preference and least preferred the potential mate with a low social proof and a high mismatch of self-preference. When comparing just social proof and mismatch of self-preference, there was not an interaction effect between the two. I conclude that even though social proof is a powerful influencing factor by itself, it did not have the power to trump the mismatch of self-preference.
ContributorsAkhter, Sumbal (Author) / Kwan, Virginia (Thesis director) / Knight, George (Committee member) / Cohen, Adam (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
When a friend approached me and asked me to join his team and apply to the Edson Student Entrepreneur Initiative, a student business plan competition at Arizona State University, I accepted. Not only did I find his idea interesting, but I also believed that applying to the Edson program would give me a first glimpse into being an entrepreneur. The business, called Social Artworking, proposed to create an online platform to connect businesses, who need art, with artists through a unique bidding process. Through Social Artworking, businesses indicate the maximum amount they are able to pay while artists bid what they are willing to do the job for. Then a business or individual is able to pick the best artist that can meet his quality and price needs. In addition to the exchange platform, Social Artworking would jointly launch a social networking site and an online portfolio service for artists. Social Artworking was trying to address the problem of small businesses having a hard time finding affordable and high quality artist and designers while at the same time helping students gain paid experience to increase their portfolio before graduation. In the months leading up to the Edson application, I had a hard time catching up to my partner's knowledge of the business idea and the art, web and crowdsourcing industries. On many occasions, I felt like I was depending on him as an expert to write the application. After two months of working on the application, we submitted the proposal to Edson. The idea did not advance to the final round.
ContributorsDuran, Regina (Author) / Peck, Sidnee (Thesis director) / Essig, Linda (Committee member) / Garner, Benson (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor)
Created2012-12
Description
Many high school students demonstrate an overall lack of interest in science. Traditional teaching methodologies seem to be unsuccessful at engaging students \u2014 one explanation is that students often interpret what they learn in school as irrelevant to their personal lives. Active learning and case based learning methodologies seem to be more effective at promoting interest and understanding of scientific principles. The purpose of our research was to implement a lab with updated teaching methodologies that included an active learning and case based curriculum. The lab was implemented in two high school honors biology classes with the specific goals of: significantly increasing students' interest in science and its related fields; increasing students' self-efficacy in their ability to understand and interpret the traditional process of the scientific method; and increasing this traditional process of objectively understanding the scientific method. Our results indicated that interest in science and its related fields (p = .011), students' self-efficacy in understanding the scientific method (p = .000), and students' objective understanding of the scientific method (p = .000) statistically significantly increased after the lab was administered; however, our results may not be as meaningful as the p-values imply due to the scale of our assessment.
ContributorsCotten, Kathryn (Author) / Hoffner, Kristin (Thesis director) / Stout, Valerie (Committee member) / Lynskey, Jim (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor)
Created2012-12