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Medulloblastoma is the most common pediatric brain cancer and accounts for 20% of all pediatric brain tumors. Upon diagnosis, patients undergo tumor-resection surgery followed by intense chemotherapy and cerebrospinal irradiation (CSI) regimens. CSI therapy is highly toxic and poorly tolerated in pediatric patients and is known to cause long-term neurocognitive,

Medulloblastoma is the most common pediatric brain cancer and accounts for 20% of all pediatric brain tumors. Upon diagnosis, patients undergo tumor-resection surgery followed by intense chemotherapy and cerebrospinal irradiation (CSI) regimens. CSI therapy is highly toxic and poorly tolerated in pediatric patients and is known to cause long-term neurocognitive, endocrine, and developmental deficits that often diminish the quality of life for medulloblastoma patients. The development of targeted therapies is necessary for both increasing the chance of survival and reducing treatment-related morbidities. A potential therapeutic target of interest in medulloblastoma is the polyamine biosynthesis pathway. Polyamines are metabolites present in every living organism and are essential for cellular processes such as growth, survival, and differentiation. Recent studies have shown that polyamine production is dysregulated in several cancers, including brain cancers, and have highlighted polyamine biosynthesis as a potential cancer growth dependency. Dysregulated polyamine metabolism has also been linked to several oncogenic drivers, including the WNT, SHH, and MYC signaling pathways that characterize genetically distinct medulloblastoma subgroups. One way to target polyamine biosynthesis is through the inhibition of the rate-limiting enzyme ornithine decarboxylase with difluoromethylornithine (DFMO), an analog of the polyamine precursor ornithine. DFMO is well-tolerated in pediatric populations and exerts minimal toxicities, as shown through neuroblastoma clinical trials, and is a therapy of interest for medulloblastoma. While DFMO has been tested clinically in multiple cancers, few in vitro studies have been performed to understand the exact mechanisms of anti-proliferation and cytotoxicity. Our study screened two immortalized medulloblastoma cell lines, DAOY (SHH) and D283 (non-WNT/non-SHH), and three patient-derived medulloblastoma cell lines, SL00024 (SHH), SL00668 (non-WNT/non-SHH), SL00870 (Unknown subgroup), for DFMO sensitivity and profiled the immortalized medulloblastoma cell line metabolome to understand the interactions between inhibition of polyamine metabolism with other essential metabolic processes and tumor cell growth. We found that medulloblastoma cell lines are sensitive to DFMO and the adaptive response to DFMO in medulloblastoma may be caused by increased oxidative stress and free radical scavenging. Our study hopes to inform the use of DFMO as an anti-cancer therapy in medulloblastoma by understanding the drug’s single-agent anti-proliferative mechanisms.
ContributorsFain, Caitlyn (Author) / Buetow, Kenneth (Thesis director) / Pirrotte, Patrick (Committee member) / Pathak, Khyati (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description
After the assassination of President Jovenel Moïse in 2021, Haiti was a hot topic in American news outlets. Soon after, there was footage released of Haitian migrants attempting to cross the border while border patrol agents on horseback charged at them, whipping them and shouting obscenities. Following this event, Donald

After the assassination of President Jovenel Moïse in 2021, Haiti was a hot topic in American news outlets. Soon after, there was footage released of Haitian migrants attempting to cross the border while border patrol agents on horseback charged at them, whipping them and shouting obscenities. Following this event, Donald Trump went on Fox News announcing old stereotypes about Haitians bringing AIDs to the US. He degraded Haiti similarly to how he did in his 2018 comments from an oval office meeting, when he stated that their country was a “shithole.” Following these comments and events, Haitian migrants were being refused Temporary Protected Status “TPS,” and being deported back to Haiti - the treatment they received was as congresswoman Alexandia Octavio Cortez described, in “stark contrast,” to that of the Ukrainian refugees who were automatically being granted TPS at the time. This thesis analyzes the history of Foreign Relations between the US and Haiti in order to understand the US’s involvement and responsibility for Haiti’s current state. I start with a historical analysis of American Occupation of Haiti in 1914, and continue through the Duvalier dictatorship, NGO involvement in Haiti, up until Haiti’s current political state, in order to give the socio-political context for the image portrayed of Haitians in American news, social media, film, and TV outlets. My thesis contends that racist stereotypes have been used in media and government alike to dehumanize Haitians and justify exploitative foreign policy.
ContributorsRyan, Madeleine (Author) / Cruse, Markus (Thesis director) / Bezerra, Ligia (Committee member) / Joslin, Isaac (Committee member) / Barrett, The Honors College (Contributor)
Created2024-05
Description
The use of supplier scorecards has become standard in business environments to measure performance. This need for scorecards has spurred research on the best metrics to include, shown the importance of linking each measure with long-term goals, and explained pitfalls that many scorecards fall into, such as gaming particular metrics.

The use of supplier scorecards has become standard in business environments to measure performance. This need for scorecards has spurred research on the best metrics to include, shown the importance of linking each measure with long-term goals, and explained pitfalls that many scorecards fall into, such as gaming particular metrics. This research contributed to the development of a new monthly scorecard for use at Northrop Grumman in Chandler, AZ, titled the Supplier Performance Visibility report, or SPV. The SPV uses six different metrics to cover many aspects of supplier performance that contribute to the work Northrop Grumman does for its customers. This report analyzes the ways in which the data for the scorecard was collected and the major findings during the five months of initial implementation.
ContributorsKelley, Ethan (Author) / Wiedmer, Robert (Thesis director) / Dubreuil, Jared (Committee member) / Barrett, The Honors College (Contributor) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2024-05
ContributorsKelley, Ethan (Author) / Wiedmer, Robert (Thesis director) / Dubreuil, Jared (Committee member) / Barrett, The Honors College (Contributor) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2024-05
ContributorsKelley, Ethan (Author) / Wiedmer, Robert (Thesis director) / Dubreuil, Jared (Committee member) / Barrett, The Honors College (Contributor) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2024-05
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Description
The ecological niche of a species can shift due to changing environmental conditions and lead to the species to undergo selective pressures to adapt to them. Ecological niche models are used to predict a species’ distribution based on its ecological niche. Ecological niche models can be integrated with a geographic

The ecological niche of a species can shift due to changing environmental conditions and lead to the species to undergo selective pressures to adapt to them. Ecological niche models are used to predict a species’ distribution based on its ecological niche. Ecological niche models can be integrated with a geographic information system to predict a species’ geographic distribution based on environmental variables. In this project, two reptile species that inhabit wide and variable geographic ranges, Uta stansburiana and Gopherus berlandieri, had their ecological niches predicted and mapped based off population data and climactic data. These ecological niche maps were then compared to sample populations of each species to infer and predict whether certain populations of each species were possibly under increased selective pressures. Based off these maps and comparisons, this study infers that the two species differ in which environmental variables are the most relevant to their suitability. This study also predicts that populations of U. stansburiana experiencing extremes in their most relevant values for temperature and precipitation could be under greater selective pressures, while populations of G. berlandieri experiencing lower values for their relevant temperature and precipitation variables could be under greater selective pressures. Furthermore, it can be inferred from this study that differences in these variables across each species’ range could be influencing genetic variation among their populations, in line with previous studies. Further genomic study of each species can be used to test these inferences.
ContributorsLukasik-Drescher, Zachary (Author) / Kusumi, Kenro (Thesis director) / Araya-Donoso, Raúl (Committee member) / Barrett, The Honors College (Contributor) / School of Geographical Sciences and Urban Planning (Contributor)
Created2024-05
Description
This thesis explores the correlation between demographic factors and gun violence rates in Mohave and Yuma Counties in Arizona from a public health perspective. With the growing recognition of gun violence as a significant public health issue, this research aims to identify specific demographic characteristics that influence rates of gun-related

This thesis explores the correlation between demographic factors and gun violence rates in Mohave and Yuma Counties in Arizona from a public health perspective. With the growing recognition of gun violence as a significant public health issue, this research aims to identify specific demographic characteristics that influence rates of gun-related homicides and suicides.
ContributorsVarma, Medha (Author) / Young, Alex (Thesis director) / Karkee, Rajendra (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / School of Politics and Global Studies (Contributor)
Created2024-05
Description
The project was to develop a US GAAP and IFRS based financial reporting software application. The application will reference the relevant codification under US GAAP or IFRS accounting standards and provide the user with a step-by-step guide to recording technical accounting entries dictated under the relevant codification or standard. The software solves for

The project was to develop a US GAAP and IFRS based financial reporting software application. The application will reference the relevant codification under US GAAP or IFRS accounting standards and provide the user with a step-by-step guide to recording technical accounting entries dictated under the relevant codification or standard. The software solves for the need to hire external expertise to perform such tasks. Through a series of relevant inputs, in-house accounting staff (or students) are afforded the opportunity to methodically work through the accounting topic or arrangement with reference to the codification and accounting standards. The software provides the final deliverables generally expected for financial reporting.
ContributorsVillani, Jacob (Author) / Macabou, Elise (Co-author) / Jain, Sejal (Co-author) / Lim, Jonathan (Co-author) / Call, Andy (Thesis director) / Hunt, Neil (Committee member) / Barrett, The Honors College (Contributor) / School of Accountancy (Contributor) / Department of Information Systems (Contributor)
Created2024-05
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Description

Foodways have been a component of archaeological research for decades. However, cooking and food preparation, as specific acts that could reveal social information about life beyond the kitchen, only became a focus of archaeological inquiry more recently. A review of the literature on cooking and food preparation reveals a shift

Foodways have been a component of archaeological research for decades. However, cooking and food preparation, as specific acts that could reveal social information about life beyond the kitchen, only became a focus of archaeological inquiry more recently. A review of the literature on cooking and food preparation reveals a shift from previous studies on subsistence strategies, consumption, and feasting. The new research is different because of the social questions that are asked, the change in focus to preparation and production rather than consumption, and the interest in highlighting marginalized people and their daily experiences. The theoretical perspectives the literature addresses revolve around practice, agency, and gender. As a result, this new focus of archaeological research on cooking and preparing food is grounded in anthropology.

ContributorsGraff, Sarah (Author) / Barrett, The Honors College (Contributor)
Created2017-10-04
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Description

Scholarly communication is at an unprecedented turning point created in part by the increasing saliency of data stewardship and data sharing. Formal data management plans represent a new emphasis in research, enabling access to data at higher volumes and more quickly, and the potential for replication and augmentation of existing

Scholarly communication is at an unprecedented turning point created in part by the increasing saliency of data stewardship and data sharing. Formal data management plans represent a new emphasis in research, enabling access to data at higher volumes and more quickly, and the potential for replication and augmentation of existing research. Data sharing has recently transformed the practice, scope, content, and applicability of research in several disciplines, in particular in relation to spatially specific data. This lends exciting potentiality, but the most effective ways in which to implement such changes, particularly for disciplines involving human subjects and other sensitive information, demand consideration. Data management plans, stewardship, and sharing, impart distinctive technical, sociological, and ethical challenges that remain to be adequately identified and remedied. Here, we consider these and propose potential solutions for their amelioration.

ContributorsHartter, Joel (Author) / Ryan, Sadie J. (Author) / MacKenzie, Catrina A. (Author) / Parker, John (Author) / Strasser, Carly A. (Author) / Barrett, The Honors College (Contributor)
Created2013-09-13