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- Genre: Doctoral Dissertation
- Creators: Davulcu, Hasan
- Creators: Xue, Guoliang
Description
As pointed out in the keynote speech by H. V. Jagadish in SIGMOD'07, and also commonly agreed in the database community, the usability of structured data by casual users is as important as the data management systems' functionalities. A major hardness of using structured data is the problem of easily retrieving information from them given a user's information needs. Learning and using a structured query language (e.g., SQL and XQuery) is overwhelmingly burdensome for most users, as not only are these languages sophisticated, but the users need to know the data schema. Keyword search provides us with opportunities to conveniently access structured data and potentially significantly enhances the usability of structured data. However, processing keyword search on structured data is challenging due to various types of ambiguities such as structural ambiguity (keyword queries have no structure), keyword ambiguity (the keywords may not be accurate), user preference ambiguity (the user may have implicit preferences that are not indicated in the query), as well as the efficiency challenges due to large search space. This dissertation performs an expansive study on keyword search processing techniques as a gateway for users to access structured data and retrieve desired information. The key issues addressed include: (1) Resolving structural ambiguities in keyword queries by generating meaningful query results, which involves identifying relevant keyword matches, identifying return information, composing query results based on relevant matches and return information. (2) Resolving structural, keyword and user preference ambiguities through result analysis, including snippet generation, result differentiation, result clustering, result summarization/query expansion, etc. (3) Resolving the efficiency challenge in processing keyword search on structured data by utilizing and efficiently maintaining materialized views. These works deliver significant technical contributions towards building a full-fledged search engine for structured data.
ContributorsLiu, Ziyang (Author) / Chen, Yi (Thesis advisor) / Candan, Kasim S (Committee member) / Davulcu, Hasan (Committee member) / Jagadish, H V (Committee member) / Arizona State University (Publisher)
Created2011
Description
Genes have widely different pertinences to the etiology and pathology of diseases. Thus, they can be ranked according to their disease-significance on a genomic scale, which is the subject of gene prioritization. Given a set of genes known to be related to a disease, it is reasonable to use them as a basis to determine the significance of other candidate genes, which will then be ranked based on the association they exhibit with respect to the given set of known genes. Experimental and computational data of various kinds have different reliability and relevance to a disease under study. This work presents a gene prioritization method based on integrated biological networks that incorporates and models the various levels of relevance and reliability of diverse sources. The method is shown to achieve significantly higher performance as compared to two well-known gene prioritization algorithms. Essentially, no bias in the performance was seen as it was applied to diseases of diverse ethnology, e.g., monogenic, polygenic and cancer. The method was highly stable and robust against significant levels of noise in the data. Biological networks are often sparse, which can impede the operation of associationbased gene prioritization algorithms such as the one presented here from a computational perspective. As a potential approach to overcome this limitation, we explore the value that transcription factor binding sites can have in elucidating suitable targets. Transcription factors are needed for the expression of most genes, especially in higher organisms and hence genes can be associated via their genetic regulatory properties. While each transcription factor recognizes specific DNA sequence patterns, such patterns are mostly unknown for many transcription factors. Even those that are known are inconsistently reported in the literature, implying a potentially high level of inaccuracy. We developed computational methods for prediction and improvement of transcription factor binding patterns. Tests performed on the improvement method by employing synthetic patterns under various conditions showed that the method is very robust and the patterns produced invariably converge to nearly identical series of patterns. Preliminary tests were conducted to incorporate knowledge from transcription factor binding sites into our networkbased model for prioritization, with encouraging results. Genes have widely different pertinences to the etiology and pathology of diseases. Thus, they can be ranked according to their disease-significance on a genomic scale, which is the subject of gene prioritization. Given a set of genes known to be related to a disease, it is reasonable to use them as a basis to determine the significance of other candidate genes, which will then be ranked based on the association they exhibit with respect to the given set of known genes. Experimental and computational data of various kinds have different reliability and relevance to a disease under study. This work presents a gene prioritization method based on integrated biological networks that incorporates and models the various levels of relevance and reliability of diverse sources. The method is shown to achieve significantly higher performance as compared to two well-known gene prioritization algorithms. Essentially, no bias in the performance was seen as it was applied to diseases of diverse ethnology, e.g., monogenic, polygenic and cancer. The method was highly stable and robust against significant levels of noise in the data. Biological networks are often sparse, which can impede the operation of associationbased gene prioritization algorithms such as the one presented here from a computational perspective. As a potential approach to overcome this limitation, we explore the value that transcription factor binding sites can have in elucidating suitable targets. Transcription factors are needed for the expression of most genes, especially in higher organisms and hence genes can be associated via their genetic regulatory properties. While each transcription factor recognizes specific DNA sequence patterns, such patterns are mostly unknown for many transcription factors. Even those that are known are inconsistently reported in the literature, implying a potentially high level of inaccuracy. We developed computational methods for prediction and improvement of transcription factor binding patterns. Tests performed on the improvement method by employing synthetic patterns under various conditions showed that the method is very robust and the patterns produced invariably converge to nearly identical series of patterns. Preliminary tests were conducted to incorporate knowledge from transcription factor binding sites into our networkbased model for prioritization, with encouraging results. To validate these approaches in a disease-specific context, we built a schizophreniaspecific network based on the inferred associations and performed a comprehensive prioritization of human genes with respect to the disease. These results are expected to be validated empirically, but computational validation using known targets are very positive.
ContributorsLee, Jang (Author) / Gonzalez, Graciela (Thesis advisor) / Ye, Jieping (Committee member) / Davulcu, Hasan (Committee member) / Gallitano-Mendel, Amelia (Committee member) / Arizona State University (Publisher)
Created2011
Description
Data-driven applications are becoming increasingly complex with support for processing events and data streams in a loosely-coupled distributed environment, providing integrated access to heterogeneous data sources such as relational databases and XML documents. This dissertation explores the use of materialized views over structured heterogeneous data sources to support multiple query optimization in a distributed event stream processing framework that supports such applications involving various query expressions for detecting events, monitoring conditions, handling data streams, and querying data. Materialized views store the results of the computed view so that subsequent access to the view retrieves the materialized results, avoiding the cost of recomputing the entire view from base data sources. Using a service-based metadata repository that provides metadata level access to the various language components in the system, a heuristics-based algorithm detects the common subexpressions from the queries represented in a mixed multigraph model over relational and structured XML data sources. These common subexpressions can be relational, XML or a hybrid join over the heterogeneous data sources. This research examines the challenges in the definition and materialization of views when the heterogeneous data sources are retained in their native format, instead of converting the data to a common model. LINQ serves as the materialized view definition language for creating the view definitions. An algorithm is introduced that uses LINQ to create a data structure for the persistence of these hybrid views. Any changes to base data sources used to materialize views are captured and mapped to a delta structure. The deltas are then streamed within the framework for use in the incremental update of the materialized view. Algorithms are presented that use the magic sets query optimization approach to both efficiently materialize the views and to propagate the relevant changes to the views for incremental maintenance. Using representative scenarios over structured heterogeneous data sources, an evaluation of the framework demonstrates an improvement in performance. Thus, defining the LINQ-based materialized views over heterogeneous structured data sources using the detected common subexpressions and incrementally maintaining the views by using magic sets enhances the efficiency of the distributed event stream processing environment.
ContributorsChaudhari, Mahesh Balkrishna (Author) / Dietrich, Suzanne W (Thesis advisor) / Urban, Susan D (Committee member) / Davulcu, Hasan (Committee member) / Chen, Yi (Committee member) / Arizona State University (Publisher)
Created2011
Description
Multi-task learning (MTL) aims to improve the generalization performance (of the resulting classifiers) by learning multiple related tasks simultaneously. Specifically, MTL exploits the intrinsic task relatedness, based on which the informative domain knowledge from each task can be shared across multiple tasks and thus facilitate the individual task learning. It is particularly desirable to share the domain knowledge (among the tasks) when there are a number of related tasks but only limited training data is available for each task. Modeling the relationship of multiple tasks is critical to the generalization performance of the MTL algorithms. In this dissertation, I propose a series of MTL approaches which assume that multiple tasks are intrinsically related via a shared low-dimensional feature space. The proposed MTL approaches are developed to deal with different scenarios and settings; they are respectively formulated as mathematical optimization problems of minimizing the empirical loss regularized by different structures. For all proposed MTL formulations, I develop the associated optimization algorithms to find their globally optimal solution efficiently. I also conduct theoretical analysis for certain MTL approaches by deriving the globally optimal solution recovery condition and the performance bound. To demonstrate the practical performance, I apply the proposed MTL approaches on different real-world applications: (1) Automated annotation of the Drosophila gene expression pattern images; (2) Categorization of the Yahoo web pages. Our experimental results demonstrate the efficiency and effectiveness of the proposed algorithms.
ContributorsChen, Jianhui (Author) / Ye, Jieping (Thesis advisor) / Kumar, Sudhir (Committee member) / Liu, Huan (Committee member) / Xue, Guoliang (Committee member) / Arizona State University (Publisher)
Created2011
Description
"Modernist Vintages" considers the significance of wine in a selection of modernist texts that includes Oscar Wilde's Salomé (1891), Dorothy Richardson's Honeycomb (1917), James Joyce's Ulysses (1922), and Evelyn Waugh's Brideshead Revisited: The Sacred and Profane Memories of Captain Charles Ryder (1945). The representations of wine in these fictions respond to the creative and destructive depictions of wine that have imbued the narratives of myth, religion, and philosophy for thousands of years; simultaneously, these works recreate and reflect on numerous wine-related events and movements that shaped European discourse in the nineteenth and twentieth centuries. The modernists use wine's conventional associations to diverse and innovative ends: as the playwright August Strindberg writes, "New forms have not been found for the new content, so that the new wine has burst the old bottles." Wine in these works alternately, and often concurrently, evokes themes that were important to the modernists, including notions of indulgence and waste, pleasure and addiction, experimentation and ritual, tradition and nostalgia, regional distinction and global expansion, wanton intoxication and artistic clarity. This project also discusses various nineteenth- and twentieth-century contexts that informed these works and that continue to shape our reading of them, including the propagation of restaurant culture; the development of a gastronomic literary tradition; the condemnation of alcohol by temperance strategists; the demarcation of wine as a "luxury good"; the professionalization and slow democratization of wine drinking and buying; the rise of popular, philosophical, and professional interest in the psychological and physiological effects of intoxication; and the influence of war on wine markets and popular attitudes toward wine. "Modernist Vintages" aims to demonstrate that the inclusion of objects like wine in modernist fiction is purposeful and meaningful, and thus inspires new and fruitful discussion about the works, writers, and nature of literary modernism in Europe.
ContributorsWaugh, Laura (Author) / Lussier, Mark (Thesis advisor) / Bivona, Daniel (Committee member) / Bixby, Patrick (Committee member) / Arizona State University (Publisher)
Created2013
Description
Sparsity has become an important modeling tool in areas such as genetics, signal and audio processing, medical image processing, etc. Via the penalization of l-1 norm based regularization, the structured sparse learning algorithms can produce highly accurate models while imposing various predefined structures on the data, such as feature groups or graphs. In this thesis, I first propose to solve a sparse learning model with a general group structure, where the predefined groups may overlap with each other. Then, I present three real world applications which can benefit from the group structured sparse learning technique. In the first application, I study the Alzheimer's Disease diagnosis problem using multi-modality neuroimaging data. In this dataset, not every subject has all data sources available, exhibiting an unique and challenging block-wise missing pattern. In the second application, I study the automatic annotation and retrieval of fruit-fly gene expression pattern images. Combined with the spatial information, sparse learning techniques can be used to construct effective representation of the expression images. In the third application, I present a new computational approach to annotate developmental stage for Drosophila embryos in the gene expression images. In addition, it provides a stage score that enables one to more finely annotate each embryo so that they are divided into early and late periods of development within standard stage demarcations. Stage scores help us to illuminate global gene activities and changes much better, and more refined stage annotations improve our ability to better interpret results when expression pattern matches are discovered between genes.
ContributorsYuan, Lei (Author) / Ye, Jieping (Thesis advisor) / Wang, Yalin (Committee member) / Xue, Guoliang (Committee member) / Kumar, Sudhir (Committee member) / Arizona State University (Publisher)
Created2013
Description
The complexity of the systems that software engineers build has continuously grown since the inception of the field. What has not changed is the engineers' mental capacity to operate on about seven distinct pieces of information at a time. The widespread use of UML has led to more abstract software design activities, however the same cannot be said for reverse engineering activities. The introduction of abstraction to reverse engineering will allow the engineer to move farther away from the details of the system, increasing his ability to see the role that domain level concepts play in the system. In this thesis, we present a technique that facilitates filtering of classes from existing systems at the source level based on their relationship to concepts in the domain via a classification method using machine learning. We showed that concepts can be identified using a machine learning classifier based on source level metrics. We developed an Eclipse plugin to assist with the process of manually classifying Java source code, and collecting metrics and classifications into a standard file format. We developed an Eclipse plugin to act as a concept identifier that visually indicates a class as a domain concept or not. We minimized the size of training sets to ensure a useful approach in practice. This allowed us to determine that a training set of 7:5 to 10% is nearly as effective as a training set representing 50% of the system. We showed that random selection is the most consistent and effective means of selecting a training set. We found that KNN is the most consistent performer among the learning algorithms tested. We determined the optimal feature set for this classification problem. We discussed two possible structures besides a one to one mapping of domain knowledge to implementation. We showed that classes representing more than one concept are simply concepts at differing levels of abstraction. We also discussed composite concepts representing a domain concept implemented by more than one class. We showed that these composite concepts are difficult to detect because the problem is NP-complete.
ContributorsCarey, Maurice (Author) / Colbourn, Charles (Thesis advisor) / Collofello, James (Thesis advisor) / Davulcu, Hasan (Committee member) / Sarjoughian, Hessam S. (Committee member) / Ye, Jieping (Committee member) / Arizona State University (Publisher)
Created2013
Description
This dissertation considers the literary and cultural response of the labor-class poets to the emerging forces of Foucauldian biopolitics in early modern Britain to shed new light on the cultural impacts of biopower upon the rural community in early modern Britain. The analysis demonstrates how the labor class literary response is characterized by an exterior experience with the nonhuman in an alternative mode to the Wordsworthian experience of the interior. I then use labor-class poets to counter Wordsworthian notions of the immaterial State population through a critical expose of state-Subject, subject-object, and human nonhuman exterior relations as they are depicted in the labor-class poetry of late eighteenth and early nineteenth century Britain. Employing an object-ontological reading of community, I explore how the effects of biopower were inscribed in the literary artifacts of the labor-class. As a final consideration, I explore the response to postcolonial biopolitics in J.M. Coetzee's 1999 novel, Disgrace. The research takes a focused historical view, surveying a range of literary, political, and historical texts between 1760-1840 to offer new readings of Robert Bloomfield, Robert Burns, John Clare, William Cobbett, Ebenezer Elliott, Olivier Goldsmith, James Hogg, and William Wordsworth. In complement, the research offers a new reading of postcolonial biopolitics in the contemporary work of J.M Coetzee.
ContributorsBisnoff, Robert W (Author) / Lussier, Mark S. (Thesis advisor) / Bixby, Patrick (Committee member) / Broglio, Ron (Committee member) / Arizona State University (Publisher)
Created2013
Description
A principal goal of this dissertation is to study stochastic optimization and real-time scheduling in cyber-physical systems (CPSs) ranging from real-time wireless systems to energy systems to distributed control systems. Under this common theme, this dissertation can be broadly organized into three parts based on the system environments. The first part investigates stochastic optimization in real-time wireless systems, with the focus on the deadline-aware scheduling for real-time traffic. The optimal solution to such scheduling problems requires to explicitly taking into account the coupling in the deadline-aware transmissions and stochastic characteristics of the traffic, which involves a dynamic program that is traditionally known to be intractable or computationally expensive to implement. First, real-time scheduling with adaptive network coding over memoryless channels is studied, and a polynomial-time complexity algorithm is developed to characterize the optimal real-time scheduling. Then, real-time scheduling over Markovian channels is investigated, where channel conditions are time-varying and online channel learning is necessary, and the optimal scheduling policies in different traffic regimes are studied. The second part focuses on the stochastic optimization and real-time scheduling involved in energy systems. First, risk-aware scheduling and dispatch for plug-in electric vehicles (EVs) are studied, aiming to jointly optimize the EV charging cost and the risk of the load mismatch between the forecasted and the actual EV loads, due to the random driving activities of EVs. Then, the integration of wind generation at high penetration levels into bulk power grids is considered. Joint optimization of economic dispatch and interruptible load management is investigated using short-term wind farm generation forecast. The third part studies stochastic optimization in distributed control systems under different network environments. First, distributed spectrum access in cognitive radio networks is investigated by using pricing approach, where primary users (PUs) sell the temporarily unused spectrum and secondary users compete via random access for such spectrum opportunities. The optimal pricing strategy for PUs and the corresponding distributed implementation of spectrum access control are developed to maximize the PU's revenue. Then, a systematic study of the nonconvex utility-based power control problem is presented under the physical interference model in ad-hoc networks. Distributed power control schemes are devised to maximize the system utility, by leveraging the extended duality theory and simulated annealing.
ContributorsYang, Lei (Author) / Zhang, Junshan (Thesis advisor) / Tepedelenlioğlu, Cihan (Committee member) / Xue, Guoliang (Committee member) / Ying, Lei (Committee member) / Arizona State University (Publisher)
Created2012
Description
The rapid advances in wireless communications and networking have given rise to a number of emerging heterogeneous wireless and mobile networks along with novel networking paradigms, including wireless sensor networks, mobile crowdsourcing, and mobile social networking. While offering promising solutions to a wide range of new applications, their widespread adoption and large-scale deployment are often hindered by people's concerns about the security, user privacy, or both. In this dissertation, we aim to address a number of challenging security and privacy issues in heterogeneous wireless and mobile networks in an attempt to foster their widespread adoption. Our contributions are mainly fivefold. First, we introduce a novel secure and loss-resilient code dissemination scheme for wireless sensor networks deployed in hostile and harsh environments. Second, we devise a novel scheme to enable mobile users to detect any inauthentic or unsound location-based top-k query result returned by an untrusted location-based service providers. Third, we develop a novel verifiable privacy-preserving aggregation scheme for people-centric mobile sensing systems. Fourth, we present a suite of privacy-preserving profile matching protocols for proximity-based mobile social networking, which can support a wide range of matching metrics with different privacy levels. Last, we present a secure combination scheme for crowdsourcing-based cooperative spectrum sensing systems that can enable robust primary user detection even when malicious cognitive radio users constitute the majority.
ContributorsZhang, Rui (Author) / Zhang, Yanchao (Thesis advisor) / Duman, Tolga Mete (Committee member) / Xue, Guoliang (Committee member) / Zhang, Junshan (Committee member) / Arizona State University (Publisher)
Created2013