Matching Items (5)
Description
The objective of this small animal pre-clinical research project was to study quantitatively the long-term micro- and macro- structural brain changes employing multiparametric MRI (Magnetic Resonance Imaging) techniques. Two separate projects make up the basis of this thesis. The first part focuses on obtaining prognostic information at early stages in the case of Traumatic Brain Injury (TBI) in rat animal model using imaging data acquired at 24-hours and 7-days post injury. The obtained parametric T2 and diffusion values from DTI (Diffusion Tensor Imaging) showed significant deviations in the signal intensities from the control and were potentially useful as an early indicator of the severity of post-traumatic injury damage. DTI was especially critical in distinguishing between the cytotoxic and vasogenic edema and in identification of injury regions resolving to normal control values by day-7. These results indicate the potential of quantitative MRI as a clinical marker in predicting prognosis following TBI. The second part of this thesis focuses on studying the effect of novel therapeutic strategies employing dendritic cell (DC) based vaccinations in mice glioma model. The treatment cohorts included comparing a single dose of Azacytidine drug vs. mice getting three doses of drug per week. Another cohort was used as an untreated control group. The MRI results did not show any significant changes in between the two treated cohorts with no reduction in tumor volumes compared to the control group. The future studies would be focused on issues regarding the optimal dose for the application of DC vaccine. Together, the quantitative MRI plays an important role in the prognosis and diagnosis of the above mentioned pathologies, providing essential information about the anatomical location, micro-structural tissue environment, lesion volume and treatment response.
ContributorsAnnaldas, Bharat (Author) / Kodibagkar, Vikram (Thesis advisor) / Stabenfeldt, Sarah (Committee member) / Bhardwaj, Ratan (Committee member) / Arizona State University (Publisher)
Created2014
Description
This dissertation considers the potential of desire to protect humans, animals, and the environment in the biopolitical times of late capitalism. Through readings of recent South African Literature in English from a postcolonial ecocritical perspective, this project theorizes desire as a mode of resistance to the neocolonial and capitalist instrumentalization of communities of humans and nonhumans, where they are often seen as mere "resources" awaiting consumption and transformation into profit. Deleuze and Guattari posit this overconsumption as stemming in part from capitalism's deployment of the psychoanalytic definition of desire as lack, where all desires are defined according to the same tragedy and brought into a money economy. By defining desire, capitalism seeks to limit the productive unconscious and attempts to create manageable subjects who perform the work of the capitalist machine--subjects that facilitate the extraction of surplus value and pleasure for themselves and the dominant classes. Thinking desire differently as positive and as potentially revolutionary, after Deleuze and Guattari, offers possible resistances to this biopolitical management. This different, positive desire can also change views of others and the world as existing solely for human consumption: views which so often risk bodies towards death and render communities unsustainable. The representations of human and animal desires (and often their cross-species desires) in this literature imagine relationships to the world otherwise, outside of a colonial legacy, where ethical response obtains instead of the consumption of others and the environment by the dominant subjects of capitalism. This project also considers other attempts to protect communities such as animal rights, arguing that rethinking desire is a necessary corollary in the effort to protect communities and lives that are made available for a "non-criminal putting to death" since positive desire precedes the passing of any such laws and must exist for their proper administration. These texts often demonstrate the law's failures to protect communities through portraying corrupt officials who risk the communities they are charged with protecting when their protection competes with government officials' personal capitalist ambitions. Desire offers opportunities for imagining other creative options towards protecting communities, outside of legal discourse.
ContributorsPrice, Jason (Author) / Broglio, Ron (Thesis advisor) / Adamson, Joni (Committee member) / Mallot, J. Edward (Committee member) / Arizona State University (Publisher)
Created2014
Description
The coyote of the natural world is an anthropomorphic figure that occupies many places within Southwestern Pueblo cultures in oral traditions as well as the natural environs. The modern-day coyote is a marginalized occupant of Southwestern milieu portrayed as an iconic character found in cartooned animations or conceptualized as a shadowed symbol of a doglike creature howling in front of a rising full moon. Coyote is also a label given to a person who transports undocumented immigrants across the United States–Mexico border. This wild dog is known as coyote, Coyote, Canis latrans, tsócki (Keresan for coyote), trickster, Wylie Coyote, and coywolf. When the biology, history, accounts, myths, and cultural constructs are placed together within the spectrum of coyote names or descriptions, a transmergent materiality emerges at the center of those contributing factors. Coyote is many things. It is constantly adapting to the environment in which it has survived for millions of years. The Southwest landscape was first occupied by rudimentary components of life evolving into a place first populated by animals, followed by humans. To a great extent, the continued existence of both animals and humans relies on their ability to obtain food and find a suitable niche in which to live. This dissertation unpacks how the coyote that is embedded in American Pueblo literature and culture depicts a transmergent materiality representing the constantly changing human–animal interface as it interprets the likewise transformative state of food systems in the American Southwest in the present day.
ContributorsMasek, Paris (Author) / Ortiz, Simon J (Thesis advisor) / Broglio, Ron (Committee member) / Blasingame, James (Committee member) / Arizona State University (Publisher)
Created2019
Description
Vivid illuminations of the aristocratic hunt decorate Bibliothèque nationale de France, MS. fr. 616, an early fifteenth-century illuminated manuscript of Le livre de chasse composed by Gaston Fébus, Count of Foix and Viscount of Béarn (1331-1391 C.E.), in 1389. Gilded miniatures visualize the medieval park, an artificial landscape designed to facilitate the ideal noble chase, depicting the various methods to pursue, capture, and kill the prey within as well as the ritual dismemberment of animals. Medieval nobles participated in the social performance of the hunt to demonstrate their inclusion in the collective identity of the aristocracy. The text and illuminations of Le livre de chasse contributed to the codification of the medieval noble hunt and became integral to the formation of cultural memory which served as the foundation for the establishment of the aristocracy as different from other parts of society in the Middle Ages. This study contributes new information through examination of previously ignored sources as well as new analysis through application of critical theoretical frameworks to interpret the manuscript as a meaning-making object within the visual culture of the Middle Ages and analysis of the illuminations reveals the complexities surrounding one of the most important acts of performance for the medieval elite.
ContributorsPratt-Sturges, Rebekah (Author) / Schleif, Corine (Thesis advisor) / Cruse, Markus (Committee member) / Cuneo, Pia (Committee member) / Arizona State University (Publisher)
Created2017
Description
A big part of understanding cancer is understanding the cellular environment itthrives in by analyzing it from a microecological perspective. Humans and other species
are affected by different cancer types, and this highlights the notion that there may be a
correlation between specific tissues and neoplasia prevalence. Research shows that
humans are the most susceptible to adenocarcinomas and carcinomas which include the
following tissues: lungs, breast, prostate, and pancreas. Furthermore, research shows that
adenocarcinoma accounts for 38.5% of all lung cancer cases, 20% of small cell
carcinomas, and 2.9% of large cell carcinoma. The incidence of the most common cancer
types in humans is consistently increasing annually. This study analyzes trends of tissue-specific cancers across species to examine possible contributors to vulnerability to
cancer. I predicted that adenocarcinomas would be the most prevalent cancer type across
the tree of life. To test this hypothesis, I reviewed over 130 species that reported equal to
or greater than 50 individual necropsy pathology records across 4 classes (Mammalia,
amphibia, Reptilia, Aves) and ranked them by neoplasia prevalence. This information was
then organized in tables in descending order. The study’s resulting tables and data
concluded that the hypothesis was correct. I found that across all species
adenocarcinomas were the most common cancer type and account for 30.4% of
malignancies reported among species. Future research should investigate how organ size
contributes to neoplasia prevalence.
ContributorsPERAZA, ASHLEY (Author) / Maley, Carlo (Thesis advisor) / Boddy, Amy (Thesis advisor) / Baciu, Cristina (Committee member) / Arizona State University (Publisher)
Created2022