Matching Items (3)
Description
Extraordinary medical advances have led to significant reductions in the burden of infectious diseases in humans. However, infectious diseases still account for more than 13 million annual deaths. This large burden is partly due to some pathogens having found suitable conditions to emerge and spread in denser and more connected host populations, and others having evolved to escape the pressures imposed by the rampant use of antimicrobials. It is then critical to improve our understanding of how diseases spread in these modern landscapes, characterized by new host population structures and socio-economic environments, as well as containment measures such as the deployment of drugs. Thus, the motivation of this dissertation is two-fold. First, we study, using both data-driven and modeling approaches, the the spread of infectious diseases in urban areas. As a case study, we use confirmed-cases data on sexually transmitted diseases (STDs) in the United States to assess the conduciveness of population size of urban areas and their socio-economic characteristics as predictors of STD incidence. We find that the scaling of STD incidence in cities is superlinear, and that the percent of African-Americans residing in cities largely determines these statistical patterns. Since disparities in access to health care are often exacerbated in urban areas, within this project we also develop two modeling frameworks to study the effect of health care disparities on epidemic outcomes. Discrepant results between the two approaches indicate that knowledge of the shape of the recovery period distribution, not just its mean and variance, is key for assessing the epidemiological impact of inequalities. The second project proposes to study, from a modeling perspective, the spread of drug resistance in human populations featuring vital dynamics, stochasticity and contact structure. We derive effective treatment regimes that minimize both the overall disease burden and the spread of resistance. Additionally, targeted treatment in structured host populations may lead to higher levels of drug resistance, and if drug-resistant strains are compensated, they can spread widely even when the wild-type strain is below its epidemic threshold.
ContributorsPatterson-Lomba, Oscar (Author) / Castillo-Chavez, Carlos (Thesis advisor) / Towers, Sherry (Thesis advisor) / Chowell-Puente, Gerardo (Committee member) / Arizona State University (Publisher)
Created2014
Description
A sequence of models is developed to describe urban population growth in the context of the embedded physical, social and economic environments and an urban disease are developed. This set of models is focused on urban growth and the relationship between the desire to move and the utility derived from city life. This utility is measured in terms of the economic opportunities in the city, the level of human constructed amenity, and the level of amenity caused by the natural environment. The set of urban disease models is focused on examining prospects of eliminating a disease for which a vaccine does not exist. It is inspired by an outbreak of the vector-borne disease dengue fever in Peru, during 2000-2001.
ContributorsMurillo, D (Author) / Castillo-Chavez, Carlos (Thesis advisor) / Anderies, John M (Thesis advisor) / Boone, Christopher (Committee member) / Arizona State University (Publisher)
Created2012
Description
In the American Southwest, an area which already experiences a significant number of cooling degree days, anthropogenic climate change is expected to result in higher average temperatures and the increasing frequency, duration, and severity of heat waves. Climatological forecasts predict heat waves will increase by 150-840% in Los Angeles County, California and 340-1800% in Maricopa County, Arizona. Heat exposure is known to increase both morbidity and mortality and rising temperatures represent a threat to public health. As a result there has been a significant amount of research into understanding existing socio-economic vulnerabilities to extreme heat which has identified population subgroups at greater risk of adverse health outcomes. Additionally, research has shown that man-made infrastructure can mitigate or exacerbate these health risks. However, while recent socio-economic heat vulnerability research has developed geospatially explicit results, research which links it directly with infrastructure characteristics is limited. Understanding how socio-economic vulnerabilities interact with infrastructure systems is a critical component to developing climate adaptation policies and programs which efficiently and effectively mitigate health risks associated with rising temperatures.
The availability of cooled space, whether public or private, has been shown to greatly reduce health risks associated with extreme heat. However, a lack of fine-scale knowledge of which households have access to this infrastructure results in an incomplete understanding of the health risks associated with heat. This knowledge gap could result in the misallocation of resources intended to mitigate negative health impacts associated with heat exposure. Additionally, when discussing accessibility to public cooled space there are underlying questions of mobility and mode choice. In addition to captive riders, a growing emphasis on walking, biking and public transit will likely expose additional choice riders to extreme temperatures and compound existing vulnerabilities to heat.
The availability of cooled space, whether public or private, has been shown to greatly reduce health risks associated with extreme heat. However, a lack of fine-scale knowledge of which households have access to this infrastructure results in an incomplete understanding of the health risks associated with heat. This knowledge gap could result in the misallocation of resources intended to mitigate negative health impacts associated with heat exposure. Additionally, when discussing accessibility to public cooled space there are underlying questions of mobility and mode choice. In addition to captive riders, a growing emphasis on walking, biking and public transit will likely expose additional choice riders to extreme temperatures and compound existing vulnerabilities to heat.
ContributorsFraser, Andrew Michael (Author) / Chester, Mikhail (Thesis advisor) / Seager, Thomas (Committee member) / Zhou, Xuesong (Committee member) / Kuby, Michael (Committee member) / Arizona State University (Publisher)
Created2016