Matching Items (19)
Description
Rapidly growing research on mothers’ perinatal depression, has demonstrated significant links among mothers’ depressive symptoms during pregnancy and the first year postpartum, their parenting, and multiple aspects of children’s development. This prospective longitudinal study contributes to research on mothers’ perinatal depression by examining the mechanisms by which maternal perinatal depression is associated with children’s adjustment early in development in a sample of 204 Mexican-origin adolescent mothers (Mage at Wave 1 = 16.80, SD = 1.0) and their children (58% boys). I expected that adolescent mothers’ negative parenting behaviors would mediate the associations between mothers’ perinatal depressive symptoms and three child outcomes: internalizing symptoms, externalizing behaviors, and cognitive ability. I further hypothesized that mothers’ perceived social support from their family would modify the extent to which mothers’ perinatal depressive symptoms negatively impact their parenting behaviors and their children’s developmental outcomes. Mothers reported on their own depressive symptoms, their perceived social support from their family and their children’s internalizing and externalizing problems; negative parenting was assessed using observational methods; and children’s cognitive ability was assessed using standardized developmental assessments. In this sample, adolescent mothers’ negative parenting behaviors did not significantly mediate the relations between mothers’ perinatal depression and children’s developmental outcomes. Further, perceived social support did not significantly buffer the effects of mothers’ perinatal depression on mothers’ negative parenting or children’s developmental outcomes. However, in line with hypotheses, results indicated that mothers’ prenatal depression had a wider impact on children’s adjustment outcomes than mothers’ postpartum depression, which appeared more specific to children’s internalizing problems. Discussion focuses on implications for intervention addressing adolescent mothers’ perinatal depression, as well as the need to continue to explore protective factors that have the potential to disrupt the negative intergenerational transmission of risks.
ContributorsSeay, Danielle M (Author) / Elam, Kit (Thesis advisor) / Iida, Masumi (Thesis advisor) / Thompson, Marilyn (Committee member) / Wilkens, Natalie (Committee member) / Arizona State University (Publisher)
Created2019
Description
Evidence from the 20th century demonstrated that early life stress (ELS) produces long lasting neuroendocrine and behavioral effects related to an increased vulnerability towards psychiatric illnesses such as major depressive disorder, post-traumatic stress disorder, schizophrenia, and substance use disorder. Substance use disorders (SUDs) are complex neurological and behavioral psychiatric illnesses. The development, maintenance, and relapse of SUDs involve multiple brain systems and are affected by many variables, including socio-economic and genetic factors. Pre-clinical studies demonstrate that ELS affects many of the same systems, such as the reward circuitry and executive function involved with addiction-like behaviors. Previous research has focused on cocaine, ethanol, opiates, and amphetamine, while few studies have investigated ELS and methamphetamine (METH) vulnerability. METH is a highly addictive psychostimulant that when abused, has deleterious effects on the user and society. However, a critical unanswered question remains; how do early life experiences modulate both neural systems and behavior in adulthood? The emerging field of neuroepigenetics provides a potential answer to this question. Methyl CpG binding protein 2 (MeCP2), an epigenetic tag, has emerged as one possible mediator between initial drug use and the transition to addiction. Additionally, there are various neural systems that undergo long lasting epigenetics changes after ELS, such as the response of the hypothalamo-pituitary-adrenal (HPA) axis to stressors. Despite this, little attention has been given to the interactions between ELS, epigenetics, and addiction vulnerability. The studies described herein investigated the effects of ELS on METH self-administration (SA) in adult male rats. Next, we investigated the effects of ELS and METH SA on MeCP2 expression in the nucleus accumbens and dorsal striatum. Additionally, we investigated the effects of virally-mediated knockdown of MeCP2 expression in the nucleus accumbens core on METH SA, motivation to obtain METH under conditions of increasing behavioral demand, and reinstatement of METH-seeking in rats with and without a history of ELS. The results of these studies provide insights into potential epigenetic mechanisms by which ELS can produce an increased vulnerability to addiction in adulthood. Moreover, these studies shed light on possible novel molecular targets for treating addiction in individuals with a history of ELS.
ContributorsLewis, Candace (Author) / Olive, M. Foster (Thesis advisor) / Hammer, Ronald (Committee member) / Neisewander, Janet (Committee member) / Sanabria, Federico (Committee member) / Arizona State University (Publisher)
Created2015
Description
The parent-child relationship is one of the earliest and most formative experiences for social and emotional development. Synchrony, defined as the rhythmic patterning and quality of mutual affect, engagement, and physiological attunement, has been identified as a critical quality of a healthy mother-infant relationship. Although the salience of the quality of family interaction has been well-established, clinical and developmental research has varied widely in methods for observing and identifying influential aspects of synchrony. In addition, modern dynamic perspectives presume multiple factors converge in a complex system influenced by both nature and nurture, in which individual traits, behavior, and environment are inextricably intertwined within the system of dyadic relational units.
The present study aimed to directly examine and compare synchrony from three distinct approaches: observed microanalytic behavioral sequences, observed global dyadic qualities, and physiological attunement between mothers and infants. The sample consisted of 323 Mexican American mothers and their infants followed from the third trimester of pregnancy through the first year of life. Mothers were interviewed prenatally, observed at a home visit at 12 weeks postpartum, and were finally interviewed for child social-emotional problems at child age 12 months. Specific aspects of synchrony (microanalytical, global, and physiological) were examined separately as well as together to identify comparable and divergent qualities within the construct.
Findings indicated that multiple perspectives on synchrony are best examined together, but as independent qualities to account for varying characteristics captured by divergent systems. Dyadic relationships characterized by higher reciprocity, more time and flexibility in mutual non-negative engagement, and less tendency to enter negative or unengaged states were associated with fewer child social-emotional problems at child age 12 months. Lower infant cortisol was associated with higher levels of externalizing problems, and smaller differences between mother and child cortisol were associated with higher levels of child dysregulation. Results underscore the complex but important nature of synchrony as a salient mechanism underlying the social-emotional growth of children. A mutually engaged, non-negative, and reciprocal environment lays the foundation for the successful social and self-regulatory competence of infants in the first year of life.
The present study aimed to directly examine and compare synchrony from three distinct approaches: observed microanalytic behavioral sequences, observed global dyadic qualities, and physiological attunement between mothers and infants. The sample consisted of 323 Mexican American mothers and their infants followed from the third trimester of pregnancy through the first year of life. Mothers were interviewed prenatally, observed at a home visit at 12 weeks postpartum, and were finally interviewed for child social-emotional problems at child age 12 months. Specific aspects of synchrony (microanalytical, global, and physiological) were examined separately as well as together to identify comparable and divergent qualities within the construct.
Findings indicated that multiple perspectives on synchrony are best examined together, but as independent qualities to account for varying characteristics captured by divergent systems. Dyadic relationships characterized by higher reciprocity, more time and flexibility in mutual non-negative engagement, and less tendency to enter negative or unengaged states were associated with fewer child social-emotional problems at child age 12 months. Lower infant cortisol was associated with higher levels of externalizing problems, and smaller differences between mother and child cortisol were associated with higher levels of child dysregulation. Results underscore the complex but important nature of synchrony as a salient mechanism underlying the social-emotional growth of children. A mutually engaged, non-negative, and reciprocal environment lays the foundation for the successful social and self-regulatory competence of infants in the first year of life.
ContributorsCoburn, Shayna Skelley (Author) / Crnic, Keith A (Thesis advisor) / Dishion, Thomas J (Committee member) / Mackinnon, David P (Committee member) / Luecken, Linda J. (Committee member) / Arizona State University (Publisher)
Created2015
Description
Theoretical models support conceptualizing parent-child relationships as reciprocal and transactional with each person exerting influence on the other’s behaviors and the overall quality and valence of the relationship across time. The goals of this study were twofold: 1) determine whether there were reciprocal relations in maternal hostility and child negativity across early and middle childhood, and 2) investigate whether individual characteristics (i.e., child temperamental anger and frustration and maternal neuroticism) moderated relations found in goal one. Data were from the Study of Early Child Care and Youth Development. Empirical support was found for conceptualizing mother-child interactions as reciprocal. Maternal hostility was related to a decrease in the probability children would exhibit negative behaviors during mother-child interactions measured approximately two years later. Child negativity was also associated with a significant decrease in the probability mothers would display future hostility.
Child temperamental anger and frustration was found to moderate reciprocal relations across all three parent-to-child cross-lagged paths. Children scoring high on a dispositional proclivity to react with anger and frustration were more likely to avoid maternal hostility, via a significant decrease in negativity, across time. Moderation was also supported in two of three child-to-parent lagged paths. Finally, maternal neuroticism moderated the reciprocal effects during early childhood, such that more neurotic mothers were more likely to demonstrate a decrease in the probability of hostility relative to mothers scoring lower on neuroticism. This affect was attenuated in middle childhood, with patterns becoming similar between mothers scoring high and low on neuroticism. Moreover, children of less neurotic mothers were more likely to demonstrate a decrease in the probability of exhibiting negativity from 36 to 54 months compared to children of more neurotic mothers. This effect also attenuated with patterns becoming negative at the grade 1 to grade 3 lag. Overall, the results from this study supported a transactional model of parent-child relationships, were consistent with the motivation literature, did not support a coercive process of interaction when the sample and measurement paradigm were low-risk, and generally suggested parents and children have an equal influence on the relational processes investigated from early to middle childhood.
Child temperamental anger and frustration was found to moderate reciprocal relations across all three parent-to-child cross-lagged paths. Children scoring high on a dispositional proclivity to react with anger and frustration were more likely to avoid maternal hostility, via a significant decrease in negativity, across time. Moderation was also supported in two of three child-to-parent lagged paths. Finally, maternal neuroticism moderated the reciprocal effects during early childhood, such that more neurotic mothers were more likely to demonstrate a decrease in the probability of hostility relative to mothers scoring lower on neuroticism. This affect was attenuated in middle childhood, with patterns becoming similar between mothers scoring high and low on neuroticism. Moreover, children of less neurotic mothers were more likely to demonstrate a decrease in the probability of exhibiting negativity from 36 to 54 months compared to children of more neurotic mothers. This effect also attenuated with patterns becoming negative at the grade 1 to grade 3 lag. Overall, the results from this study supported a transactional model of parent-child relationships, were consistent with the motivation literature, did not support a coercive process of interaction when the sample and measurement paradigm were low-risk, and generally suggested parents and children have an equal influence on the relational processes investigated from early to middle childhood.
ContributorsPennar, Amy LaRae (Author) / Bradley, Robert H (Thesis advisor) / Iida, Masumi (Committee member) / Spinrad, Tracy (Committee member) / Taylor, Michelle (Committee member) / Arizona State University (Publisher)
Created2016
Description
The theory of biological sensitivity to context (BSC; Boyce & Ellis, 2005) posits that specific biological characteristics, such as vagal tone, may confer risk for physical and mental health outcomes for some children but promote health for others. High levels of resting respiratory sinus arrhythmia (RSA), an index of vagal tone, may confer susceptibility to the effects of the caregiving environment on child development. Consistent with BSC, I expected that, relative to infants with lower RSA, infants with higher RSA would demonstrate fewer behavior problems if their mothers reported fewer postpartum depressive symptoms, but more behavior problems if their mothers reported more postpartum depressive symptoms. I also evaluated whether observed child social engagement with their mothers mediated children's biological sensitivity to the effects of postpartum depressive symptoms on behavior problems in early childhood. I evaluated a mediated moderation model among a sample of 322 low-income Mexican American mother-infant dyads. As expected, the RSA x maternal depressive symptoms interaction, controlling for covariates, was a significant predictor of internalizing, externalizing and total behavior problems, and high vagal tone conferred susceptibility for externalizing behavior problems. Contrary to my hypothesis, children with low RSA may be more susceptible to the effects of maternal postpartum depressive symptoms on children's internalizing and total behavior problems, and child social engagement did not account for these effects. Among infants in economically disadvantaged families, lower RSA and fewer maternal depressive symptoms may promote resilience, and more research is needed to understand behavioral mediators of biological sensitivity.
ContributorsSomers, Jennifer (Author) / Luecken, Linda (Thesis advisor) / Crnic, Keith (Committee member) / Spinrad, Tracy (Committee member) / Arizona State University (Publisher)
Created2017
Description
Scientific evidence strongly indicates that there are significant health benefits of breastfeeding. Lower breastfeeding initiation, duration, and exclusivity rates are found in vulnerable populations particularly among women of low socioeconomic status, and racial minorities such as immigrant, racial, and minority cultural groups. Breastfeeding disparities can contribute to negative health outcomes for the mothers, and their infants, and families.
Muslim Arab immigrants are a fast-growing, under-studied, and underserved minority population in the United States. Little is known about breastfeeding practices and challenges facing this vulnerable population. Immigrant Muslim Arab mothers encounter breastfeeding challenges related to religion, language, different cultural beliefs, levels of acculturation, difficulties understanding health care information, and navigating the health care system.
A cross-sectional descriptive study was used to describe infant feeding practices, and identify contributors and barriers to adequate breastfeeding using the social ecological model of health promotion. A convenience sample of 116 immigrant Muslim Arab women with at least one child, 5 years or younger was recruited from a large metropolitan area in the Southwestern United States. The results indicated that immigrant Muslim Arab mothers demonstrate high breastfeeding initiation rates (99.2%), and lengthy breastfeeding duration (M=11.86), but low rates of exclusive breastfeeding at 6 months (21.6%). Facilitators to breastfeeding within the sample were high intentions to breastfeed, positive breastfeeding knowledge and beliefs related to the benefits of breastfeeding, religious teachings promoting breastfeeding, and encouragement to breastfeed from the mothers’ social support system. Several barriers to successful breastfeeding were related to lacking the specific knowledge of the benefits of breastfeeding, and discomfort with breastfeeding in public, and in front of strangers. High income and religious teachings encouraging breastfeeding were significantly associated with exclusive breastfeeding at six months. Greater maternal age and comfort with breastfeeding in public were associated with longer breastfeeding durations.
The socio-cultural context for support of breastfeeding is an important consideration by healthcare providers caring for Muslim Arab women. An ecological perspective needs to be applied to interventions targeting breastfeeding promotion to facilitate effectiveness in this population. Culturally tailored intervention to the specific breastfeeding concerns and needs of Muslim immigrant women could promote optimal breastfeeding in this population.
Muslim Arab immigrants are a fast-growing, under-studied, and underserved minority population in the United States. Little is known about breastfeeding practices and challenges facing this vulnerable population. Immigrant Muslim Arab mothers encounter breastfeeding challenges related to religion, language, different cultural beliefs, levels of acculturation, difficulties understanding health care information, and navigating the health care system.
A cross-sectional descriptive study was used to describe infant feeding practices, and identify contributors and barriers to adequate breastfeeding using the social ecological model of health promotion. A convenience sample of 116 immigrant Muslim Arab women with at least one child, 5 years or younger was recruited from a large metropolitan area in the Southwestern United States. The results indicated that immigrant Muslim Arab mothers demonstrate high breastfeeding initiation rates (99.2%), and lengthy breastfeeding duration (M=11.86), but low rates of exclusive breastfeeding at 6 months (21.6%). Facilitators to breastfeeding within the sample were high intentions to breastfeed, positive breastfeeding knowledge and beliefs related to the benefits of breastfeeding, religious teachings promoting breastfeeding, and encouragement to breastfeed from the mothers’ social support system. Several barriers to successful breastfeeding were related to lacking the specific knowledge of the benefits of breastfeeding, and discomfort with breastfeeding in public, and in front of strangers. High income and religious teachings encouraging breastfeeding were significantly associated with exclusive breastfeeding at six months. Greater maternal age and comfort with breastfeeding in public were associated with longer breastfeeding durations.
The socio-cultural context for support of breastfeeding is an important consideration by healthcare providers caring for Muslim Arab women. An ecological perspective needs to be applied to interventions targeting breastfeeding promotion to facilitate effectiveness in this population. Culturally tailored intervention to the specific breastfeeding concerns and needs of Muslim immigrant women could promote optimal breastfeeding in this population.
ContributorsKhasawneh, Wafa (Author) / Komnenich, Pauline (Thesis advisor) / Petrov, Megan (Committee member) / Reifsnider, Elizabeth G. (Committee member) / Ahmed, Azza (Committee member) / Arizona State University (Publisher)
Created2017
Description
The maternal separation (MS) paradigm is an animal model of early life stress. Animals subjected to MS during the first two weeks of life display altered behavioral and neuroendocrinological stress responses as adults. MS also produces altered responsiveness to and self-administration (SA) of various drugs of abuse including cocaine, ethanol, opioids, and amphetamine. Methamphetamine (METH) causes great harm to both the individual user and to society; yet, no studies have examined the effects of MS on METH SA. This study was performed to examine the effects of MS on the acquisition of METH SA, extinction, and reinstatement of METH-seeking behavior in adulthood. Given the known influence of early life stress and drug exposure on epigenetic processes, group differences in levels of the epigenetic marker methyl CpG binding protein 2 (MeCP2) in the nucleus accumbens (NAc) core were also investigated. Long-Evans pups and dams were separated on postnatal days (PND) 2-14 for either 180 (MS180) or 15 min (MS15). Male offspring were allowed to acquire METH SA (0.05 mg/kg/infusion) in 15 2-hr daily sessions starting at PND67, followed by extinction training and cue-induced reinstatement of METH-seeking behavior. Rats were then assessed for MeCP2 levels in the NAc core by immunohistochemistry. The MS180 group self-administered significantly more METH and acquired SA earlier than the MS15 group. No group differences in extinction or cue-induced reinstatement were observed. MS15 rats had significantly elevated MeCP2-immunoreactive cells in the NAc core as compared to MS180 rats. Together, these data suggest that MS has lasting influences on METH SA as well as epigenetic processes in the brain reward circuitry.
ContributorsLewis, Candace (Author) / Olive, Micheal F (Thesis advisor) / Conrad, Cheryl (Committee member) / Neisewander, Janet (Committee member) / Arizona State University (Publisher)
Created2013
Description
Dysregulated cortisol has been linked to a variety of adverse physical and psychological consequences. Stressors in the childhood family environment can influence cortisol activity throughout development. For example, research has shown that both infants and children of depressed mothers exhibit altered levels of cortisol compared to infants and children of non-depressed mothers. It is unclear, however, whether exposure to maternal depression in childhood and adolescence is related to cortisol activity at later stages of development. The current study examined the longitudinal relation between maternal depressive symptoms during late childhood (9-12 years old) and adolescence (15-19 years old) and cortisol activity in offspring in young adulthood (24- 28 years old) in a sample of 40 young adults and their mothers. Maternal depressive symptoms were prospectively assessed at four time points across the 15 year study. Cortisol samples were collected from young adult offspring at the final time point. Findings revealed that higher levels of maternal depressive symptoms during late childhood were associated with lower total cortisol output in young adulthood. Results suggest that attenuated cortisol levels, which put these young adults at risk for a variety of stress-related physical and psychological illnesses, may be a long-term consequence of exposure to maternal depression,. Depressive symptoms in mothers during their child's adolescence, however, did not relate to cortisol output. These findings suggest a sensitive period in late childhood during which the development of HPA activity may be susceptible to the environmental stressor of maternal depression.
ContributorsMahrer, Nicole Eva (Author) / Wolchik, Sharlene (Thesis advisor) / Luecken, Linda (Thesis advisor) / Tein, Jenn-Yun (Committee member) / Arizona State University (Publisher)
Created2011
Description
The nature and correlates of emerging internalizing symptoms in young children are largely unknown. Maternal factors such as psychological symptoms and detached parenting style have been found to be present in children with anxiety and depression. Further, child attentional control in task completion has been associated with difficulty related to internalizing problems. This study tested hypotheses that child anxiety and depression at age five could be predicted by a combination of maternal distress and maternal detached behavior recorded at age three. An additional hypothesis was tested to determine if child attentional control at age four may be a partial mediator of the relation between maternal symptoms and parenting to child internalizing symptoms. Using structural equation modeling, no hypotheses were supported; child internalizing problems were not significantly predicted by maternal distress nor detached parenting. Further, child attentional control was not predicted by maternal distress or detached behavior, nor did attentional control predict internalizing problems. Findings indicate that over a two-year interval, childhood internalizing problems at age five are likely best predicted by early internalizing problems at age three. There was no support that the mother or child factors tested were predictive of child outcomes.
ContributorsSkelley, Shayna (Author) / Crnic, Keith A (Thesis advisor) / Eisenberg, Nancy (Committee member) / MacKinnon, David (Committee member) / Arizona State University (Publisher)
Created2010