Matching Items (5)
Description
Signal processing techniques have been used extensively in many engineering problems and in recent years its application has extended to non-traditional research fields such as biological systems. Many of these applications require extraction of a signal or parameter of interest from degraded measurements. One such application is mass spectrometry immunoassay (MSIA) which has been one of the primary methods of biomarker discovery techniques. MSIA analyzes protein molecules as potential biomarkers using time of flight mass spectrometry (TOF-MS). Peak detection in TOF-MS is important for biomarker analysis and many other MS related application. Though many peak detection algorithms exist, most of them are based on heuristics models. One of the ways of detecting signal peaks is by deploying stochastic models of the signal and noise observations. Likelihood ratio test (LRT) detector, based on the Neyman-Pearson (NP) lemma, is an uniformly most powerful test to decision making in the form of a hypothesis test. The primary goal of this dissertation is to develop signal and noise models for the electrospray ionization (ESI) TOF-MS data. A new method is proposed for developing the signal model by employing first principles calculations based on device physics and molecular properties. The noise model is developed by analyzing MS data from careful experiments in the ESI mass spectrometer. A non-flat baseline in MS data is common. The reasons behind the formation of this baseline has not been fully comprehended. A new signal model explaining the presence of baseline is proposed, though detailed experiments are needed to further substantiate the model assumptions. Signal detection schemes based on these signal and noise models are proposed. A maximum likelihood (ML) method is introduced for estimating the signal peak amplitudes. The performance of the detection methods and ML estimation are evaluated with Monte Carlo simulation which shows promising results. An application of these methods is proposed for fractional abundance calculation for biomarker analysis, which is mathematically robust and fundamentally different than the current algorithms. Biomarker panels for type 2 diabetes and cardiovascular disease are analyzed using existing MS analysis algorithms. Finally, a support vector machine based multi-classification algorithm is developed for evaluating the biomarkers' effectiveness in discriminating type 2 diabetes and cardiovascular diseases and is shown to perform better than a linear discriminant analysis based classifier.
ContributorsBuddi, Sai (Author) / Taylor, Thomas (Thesis advisor) / Cochran, Douglas (Thesis advisor) / Nelson, Randall (Committee member) / Duman, Tolga (Committee member) / Arizona State University (Publisher)
Created2012
Description
Epilepsy affects numerous people around the world and is characterized by recurring seizures, prompting the ability to predict them so precautionary measures may be employed. One promising algorithm extracts spatiotemporal correlation based features from intracranial electroencephalography signals for use with support vector machines. The robustness of this methodology is tested through a sensitivity analysis. Doing so also provides insight about how to construct more effective feature vectors.
ContributorsMa, Owen (Author) / Bliss, Daniel (Thesis director) / Berisha, Visar (Committee member) / Barrett, The Honors College (Contributor) / Electrical Engineering Program (Contributor)
Created2015-05
Description
Tracking targets in the presence of clutter is inevitable, and presents many challenges. Additionally, rapid, drastic changes in clutter density between different environments or scenarios can make it even more difficult for tracking algorithms to adapt. A novel approach to target tracking in such dynamic clutter environments is proposed using a particle filter (PF) integrated with Interacting Multiple Models (IMMs) to compensate and adapt to the transition between different clutter densities. This model was implemented for the case of a monostatic sensor tracking a single target moving with constant velocity along a two-dimensional trajectory, which crossed between regions of drastically different clutter densities. Multiple combinations of clutter density transitions were considered, using up to three different clutter densities. It was shown that the integrated IMM PF algorithm outperforms traditional approaches such as the PF in terms of tracking results and performance. The minimal additional computational expense of including the IMM more than warrants the benefits of having it supplement and amplify the advantages of the PF.
ContributorsDutson, Karl (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Kovvali, Narayan (Committee member) / Bliss, Daniel W (Committee member) / Arizona State University (Publisher)
Created2015
Description
This work details the bootstrap estimation of a nonparametric information divergence measure, the Dp divergence measure, using a power law model. To address the challenge posed by computing accurate divergence estimates given finite size data, the bootstrap approach is used in conjunction with a power law curve to calculate an asymptotic value of the divergence estimator. Monte Carlo estimates of Dp are found for increasing values of sample size, and a power law fit is used to relate the divergence estimates as a function of sample size. The fit is also used to generate a confidence interval for the estimate to characterize the quality of the estimate. We compare the performance of this method with the other estimation methods. The calculated divergence is applied to the binary classification problem. Using the inherent relation between divergence measures and classification error rate, an analysis of the Bayes error rate of several data sets is conducted using the asymptotic divergence estimate.
ContributorsKadambi, Pradyumna Sanjay (Author) / Berisha, Visar (Thesis director) / Bliss, Daniel (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The presence of strategic agents can pose unique challenges to data collection and distributed learning. This dissertation first explores the social network dimension of data collection markets, and then focuses on how the strategic agents can be efficiently and effectively incentivized to cooperate in distributed machine learning frameworks.
The first problem explores the impact of social learning in collecting and trading unverifiable information where a data collector purchases data from users through a payment mechanism. Each user starts with a personal signal which represents the knowledge about the underlying state the data collector desires to learn. Through social interactions, each user also acquires additional information from his neighbors in the social network. It is revealed that both the data collector and the users can benefit from social learning which drives down the privacy costs and helps to improve the state estimation for a given total payment budget. In the second half, a federated learning scheme to train a global learning model with strategic agents, who are not bound to contribute their resources unconditionally, is considered. Since the agents are not obliged to provide their true stochastic gradient updates and the server is not capable of directly validating the authenticity of reported updates, the learning process may reach a noncooperative equilibrium. First, the actions of the agents are assumed to be binary: cooperative or defective. If the cooperative action is taken, the agent sends a privacy-preserved version of stochastic gradient signal. If the defective action is taken, the agent sends an arbitrary uninformative noise signal. Furthermore, this setup is extended into the scenarios with more general actions spaces where the quality of the stochastic gradient updates have a range of discrete levels. The proposed methodology evaluates each agent's stochastic gradient according to a reference gradient estimate which is constructed from the gradients provided by other agents, and rewards the agent based on that evaluation.
ContributorsAkbay, Abdullah Basar (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Spanias, Andreas (Committee member) / Kosut, Oliver (Committee member) / Ewaisha, Ahmed (Committee member) / Arizona State University (Publisher)
Created2023