Matching Items (38)
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- All Subjects: Chamber music
- Creators: Landschoot, Thomas
Description
In order to cope with the decreasing availability of symphony jobs and collegiate faculty positions, many musicians are starting to pursue less traditional career paths. Also, to combat declining audiences, musicians are exploring ways to cultivate new and enthusiastic listeners through relevant and engaging performances. Due to these challenges, many community-based chamber music ensembles have been formed throughout the United States. These groups not only focus on performing classical music, but serve the needs of their communities as well. The problem, however, is that many musicians have not learned the business skills necessary to create these career opportunities. In this document I discuss the steps ensembles must take to develop sustainable careers. I first analyze how groups build a strong foundation through getting to know their communities and creating core values. I then discuss branding and marketing so ensembles can develop a public image and learn how to publicize themselves. This is followed by an investigation of how ensembles make and organize their money. I then examine the ways groups ensure long-lasting relationships with their communities and within the ensemble. I end by presenting three case studies of professional ensembles to show how groups create and maintain successful careers. Ensembles must develop entrepreneurship skills in addition to cultivating their artistry. These business concepts are crucial to the longevity of chamber groups. Through interviews of successful ensemble members and my own personal experiences in the Tetra String Quartet, I provide a guide for musicians to use when creating a community-based ensemble.
ContributorsDalbey, Jenna (Author) / Landschoot, Thomas (Thesis advisor) / McLin, Katherine (Committee member) / Ryan, Russell (Committee member) / Solis, Theodore (Committee member) / Spring, Robert (Committee member) / Arizona State University (Publisher)
Created2013
Description
The p53 gene functions as a tumor suppressor that inhibits proliferation, regulates apoptosis, DNA repair, and normal cell cycle arrest. Mutation of the p53 gene is linked to be prevalent in 50% of all human cancers. In this paper, we are exploring triple negative breast cancer and the effects of simvastatin on tumor growth and survival. Simvastatin is a drug that is primarily used to treat high cholesterol and heart disease. Simvastatin is unique because it is able to inhibit protein prenylation through regulation of the mevalonate pathway. This makes it a potential targeted drug for therapy against p53 mutant cancer. The mechanism behind this is hypothesized to be correlated to aberrant activation of the Ras pathway. The Ras subfamily functions to transcriptionally regulate cell growth and survival, and will therefore allow for a tumor to thrive if the pathway is continually and abnormally activated. The Ras protein has to be prenylated in order for activation of this pathway to occur, making statin drug treatment a viable option as a cancer treatment. This is because it acts as a regulator of the mevalonate pathway which is upstream of protein prenylation. It is thus vital to understand these pathways at both the gene and protein level in different p53 mutants to further understand if simvastatin is indeed a drug with anti-cancer properties and can be used to target cancers with p53 mutation. The goal of this project is to study the biochemistry behind the mutation of p53's sensitivity to statin. With this information we can create a possible signature for those who could benefit from Simvastatin drug treatment as a possible targeted treatment for p53 mutant cancers.
ContributorsGrewal, Harneet (Co-author) / Loo, Yi Jia Valerie (Co-author) / Anderson, Karen (Thesis director) / Blattman, Joseph (Committee member) / Ferdosi, Shayesteh (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
ContributorsGronnier, Henry (Performer) / Ngwenyama, Nokuthula (Performer) / Landschoot, Thomas (Performer) / Dokshitsky, Rina (Performer) / ASU Library. Music Library (Publisher)
Created2017-04-02
ContributorsLandschoot, Thomas (Performer) / Marelli, Michele (Performer) / Millea, Joe (Performer) / Spring, Robert (Performer) / ASU Library. Music Library (Publisher)
Created2017-11-08
ContributorsJiang, Danwen (Performer) / McLin, Katherine (Performer) / Swartz, Jonathan (Performer) / Buck, Nancy (Performer) / Landschoot, Thomas (Performer) / Rotaru, Catalin (Performer) / Schuring, Martin (Performer) / Spring, Robert (Performer) / Pagano, Caio, 1940- (Performer) / ASU Library. Music Library (Publisher)
Created2006-03-26
ContributorsRyan, Russell (Performer) / Campbell, Andrew (Pianist) (Performer) / Buck, Nancy (Performer) / Cosand, Walter, 1950- (Performer) / Schuring, Martin (Performer) / FitzPatrick, Carole (Performer) / Landschoot, Thomas (Performer) / ASU Library. Music Library (Publisher)
Created2010-09-26
ContributorsGronnier, Henry (Performer) / Diener, Thomas (Performer) / Landschoot, Thomas (Performer) / Dokshitsky, Rina (Performer) / Rossetti Piano Quartet (Performer) / ASU Library. Music Library (Publisher)
Created2016-01-24
ContributorsMancuso, Simone (Director) / Ryan, Russell (Performer) / Landschoot, Thomas (Performer) / Arizona Contemporary Music Ensemble (Performer) / ASU Library. Music Library (Publisher)
Created2014-11-16
ContributorsMoeling, Robert (Performer) / Rosenthal, Paul (Performer) / Werff, Ivo-Jan van der (Performer) / Landschoot, Thomas (Performer) / ASU Library. Music Library (Publisher)
Created2015-01-25
ContributorsCardenes, Andres (Performer) / Landschoot, Thomas (Performer) / Chen, Wendy (Performer) / ASU Library. Music Library (Publisher)
Created2018-01-21