Matching Items (2)
Description
Adaptive thermogenesis is an innate mechanism that assists the body in controlling its core temperature that can be stimulated in two ways: cold and diet. When adaptive thermogenesis is stimulated through diet, the metabolic rate of the body should increase and the metabolic efficiency of the body should decrease. This activation should, theoretically, help to control weight gain. A protocol was developed to study four male Sprague-Dawley rats throughout a fourteen week period through the measurement of brown adipose tissue blood flow and brown adipose tissue, back, and abdomen temperatures to determine if diet induced thermogenesis existed and could be activated through norepinephrine. The sedative used to obtain blood flow measurements, ketamine, was discovered to induce a thermal response prior to the norepinephrine injection by mimicking the norepinephrine response in the sympathetic nervous system. This discovery altered the original protocol to exclude an injection of norepinephrine, as this injection would have no further thermal effect. It was found that ketamine sedation excited diet induced thermogenesis in periods of youth, low fat diet, and early high fat diet. The thermogenic capacity was found to be at a peak of 2.1 degrees Celsius during this time period. The data also suggested that the activation of diet induced thermogenesis decreased as the period of high fat diet increased, and by week 4 of the high fat diet, almost all evidence of diet induced thermogenesis was suppressed. This indicated that diet induced thermogenesis is time and diet dependent. Further investigation will need to be made to determine if prolonged high fat diet or age suppress diet induced thermogenesis.
ContributorsJayo, Heather Lynn (Author) / Caplan, Michael (Thesis director) / Herman, Richard (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Major depressive disorder contributes to a growing disease burden globally, with limiting or
inadequate treatment options available to patients and healthcare providers. Traditional
medications to treat the disorder demonstrate modest efficacy while best outcomes are seen when
psychotherapy is implemented adjunctively. Barriers to delivering optimal treatment can lead to
relapse, diminished psychosocial functioning, and suicide, a leading cause of death in the United
States. The purpose of this paper is to examine the rapid antidepressant effects of ketamine
combined with nurse-delivered mindfulness-based cognitive therapy to help reduce depression
severity and support remission. Research differentiating ketamine’s mechanism of action from
traditional anti-depressants and the efficacy of mindfulness-based interventions to reduce
depression, have led this evidence-based project integrating these modalities.
ContributorsYuhas, John V. (Author) / McIntosh, Wayne (Thesis advisor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor)
Created2021-04-20