Matching Items (23)
Description
HIV/AIDS is the sixth leading cause of death worldwide and the leading cause of death among women of reproductive age living in low-income countries. Clinicians in industrialized nations monitor the efficacy of antiretroviral drugs and HIV disease progression with the HIV-1 viral load assay, which measures the copy number of HIV-1 RNA in blood. However, viral load assays are not widely available in sub-Saharan Africa and cost between 50-$139 USD per test on average where available. To address this problem, a mixed-methods approach was undertaken to design a novel and inexpensive viral load diagnostic for HIV-1 and to evaluate barriers to its adoption in a developing country. The assay was produced based on loop-mediated isothermal amplification (LAMP). Blood samples from twenty-one individuals were spiked with varying concentrations of HIV-1 RNA to evaluate the sensitivity and specificity of LAMP. Under isothermal conditions, LAMP was performed with an initial reverse-transcription step (RT-LAMP) and primers designed for HIV-1 subtype C. Each reaction generated up to a few billion copies of target DNA within an hour. Presence of target was detected through naked-eye observation of a fluorescent indicator and verified by DNA gel electrophoresis and real-time fluorescence. The assay successfully detected the presence of HIV in samples with a broad range of HIV RNA concentration, from over 120,000 copies/reaction to 120 copies/reaction. In order to better understand barriers to adoption of LAMP in developing countries, a feasibility study was undertaken in Tanzania, a low-income country facing significant problems in healthcare. Medical professionals in Northern Tanzania were surveyed for feedback regarding perspectives of current HIV assays, patient treatment strategies, availability of treatment, treatment priorities, HIV transmission, and barriers to adoption of the HIV-1 LAMP assay. The majority of medical providers surveyed indicated that the proposed LAMP assay is too expensive for their patient populations. Significant gender differences were observed in response to some survey questions. Female medical providers were more likely to cite stigma as a source problem of the HIV epidemic than male medical providers while males were more likely to cite lack of education as a source problem than female medical providers.
ContributorsSalamone, Damien Thomas (Author) / Jacobs, Bertram L (Thesis advisor) / Marsiglia, Flavio (Committee member) / Stout, Valerie (Committee member) / Johnson, Crista (Committee member) / Arizona State University (Publisher)
Created2011
Description
ABSTRACT This study examined the schooling experiences and perceptions of resettled sub-Saharan African middle school refugee students in a metropolitan area of the United States Southwest. The research questions underpinning this study included: What are the schooling experiences and perceptions of resettled sub-Saharan African middle school refugee students in a southwestern U.S. state? 1a) How do they view their relationships with their teachers and peers? 1b) Can they identify a teacher or school staff member in their school community who is a significant resource for them? and 1c) What factors contribute to their challenges and successes in their school community? This qualitative study documented and analyzed the schooling experiences and perceptions of resettled refugee middle school students, who are relatively new to the U.S. educational system. Purposive and convenience sampling were sources utilized in selecting participants for this study. Semi-structured interviews and focus groups were used to capture the stories of 10 resettled sub-Saharan African refugee students enrolled in 7th and 8th grade, who have lived in the U.S. not more than 10 years and not less than three years. Among the participants, half were male and half female. They came from six countries: Burundi, Democratic Republic of Congo, Liberia, Rwanda, Sierra Leone and Somalia. Findings of the study revealed six major themes: teachers' helpfulness, positive perceptions of school, friends as resources at school, disruptive students in the classroom, need for better teachers, and before and after school activities. Overall, the participants in the study expressed a positive perception of their teachers and their schools, yet presented a dichotomous view of their schooling experiences and perceptions.
ContributorsSallu, Adama (Author) / Swadener, Beth B (Thesis advisor) / Klimek, Barbara (Committee member) / Miller, Lynn (Committee member) / Arizona State University (Publisher)
Created2012
Description
ABSTRACT
Malawi, as a low and middle income country (LMIC), with one of the lowest per capita gross domestic products, faces challenges in the provision of healthcare to its citizens. According to the Centers for Disease Control (CDC), leading causes of death include but are not limited to, lower respiratory disease, stroke, cancer, neonatal disorders, and nutritional deficiencies. Feeding and swallowing disorders can present as a symptom to any of these medical diagnoses. Currently, there are no known studies focusing on the service provision for feeding and swallowing disorders in Malawi.
This pilot study was designed to provide a baseline on how feeding and swallowing disorders are currently being provided for in an emerging country like Malawi. Malawian healthcare professionals who see patients with feeding and swallowing disorders completed a survey and interview pertaining to their personal demographics, caseload, opinions, experiences, and treatment recommendations regarding the management of swallowing disorders (dysphagia).
Results indicate a wide range of occupations (Otolaryngoloists, Rehabilitation Technicians, Audiology Technicians, and Nurses) are involved in feeding and swallowing care. Participants expressed a high obligation to provide services for feeding and swallowing disorders, as well as a high concern for their patients. Generally, participants expressed high confidence in their treatment abilities, which did not correspond to knowledge of treatment recommendations that meet U.S. standards of care. Specifically, there was no variation in treatment recommendations across severities and a general lack of resources and tools for assessing and treating dysphagia. Treatment recommendations tended to align with resources currently available in Malawi.
Implications for the utilization of NGOs (non-governmental organizations) and the education of healthcare providers on feeding and swallowing disorders in the social and cultural contexts of this country are discussed.
Malawi, as a low and middle income country (LMIC), with one of the lowest per capita gross domestic products, faces challenges in the provision of healthcare to its citizens. According to the Centers for Disease Control (CDC), leading causes of death include but are not limited to, lower respiratory disease, stroke, cancer, neonatal disorders, and nutritional deficiencies. Feeding and swallowing disorders can present as a symptom to any of these medical diagnoses. Currently, there are no known studies focusing on the service provision for feeding and swallowing disorders in Malawi.
This pilot study was designed to provide a baseline on how feeding and swallowing disorders are currently being provided for in an emerging country like Malawi. Malawian healthcare professionals who see patients with feeding and swallowing disorders completed a survey and interview pertaining to their personal demographics, caseload, opinions, experiences, and treatment recommendations regarding the management of swallowing disorders (dysphagia).
Results indicate a wide range of occupations (Otolaryngoloists, Rehabilitation Technicians, Audiology Technicians, and Nurses) are involved in feeding and swallowing care. Participants expressed a high obligation to provide services for feeding and swallowing disorders, as well as a high concern for their patients. Generally, participants expressed high confidence in their treatment abilities, which did not correspond to knowledge of treatment recommendations that meet U.S. standards of care. Specifically, there was no variation in treatment recommendations across severities and a general lack of resources and tools for assessing and treating dysphagia. Treatment recommendations tended to align with resources currently available in Malawi.
Implications for the utilization of NGOs (non-governmental organizations) and the education of healthcare providers on feeding and swallowing disorders in the social and cultural contexts of this country are discussed.
ContributorsLarson, Christie Taylor (Author) / Azuma, Tamiko (Thesis advisor) / Scherer, Nancy (Thesis advisor) / Helms-Tillery, Kate (Committee member) / Arizona State University (Publisher)
Created2018
Description
This dissertation research describes the hunting behavior of early modern humans through the analysis of vertebrate faunal remains from Contrebandiers Cave, Morocco. Contrebandiers Cave is located in the town of Témara and is roughly 250 meters from the current shoreline of the Atlantic Ocean. The cave was excavated in the 1950s and 1970s by l’Abbé Roche, and again starting in 2007 by Dibble and El Hajraoui with total station plotting of finds. Contrebandiers Cave contains Middle Stone Age (MSA) deposits dated to Marine Isotope Stages (MIS) 5e, 5d and 5c, ~120,000 to ~96,000 years ago. The Later Stone Age (LSA) deposits are dated to MIS 2, ~20,000 years ago. The entirety of the ~12,000 vertebrate faunal remains from Dibble and El Hajraoui’s excavation were analyzed for taxonomic and taphonomic identification.
A total of 67 vertebrate taxa were identified and include ungulates, carnivores, lagomorphs, birds, tortoises, snakes and fish. The faunal remains from Contrebandiers Cave preserve surface modification that indicates both humans and carnivores acted as agents of prey accumulation. Skeletal element representation and surface modification of ungulate remains suggest that humans had primary access to small, medium and large-bodied prey. In the MSA levels, carnivore skeletal remains preserve surface modification that is interpreted as being indicative of behavior associated with skinning for fur removal.
The vertebrate faunal remains from MIS 5e and 5d indicate that humans were hunting grazers and mixed feeders from open habitats and suids from mixed habitats. The faunal remains from MIS 5c indicate that humans focused less on suids and more on mixed feeders from open habitats. The vertebrate faunal remains from MIS 2 reveal humans hunting grazers from dry, open habitats. This research provides a description of human hunting behavior in North Africa, and contributes to our understanding of early modern human behavior prior to dispersal out of Africa.
A total of 67 vertebrate taxa were identified and include ungulates, carnivores, lagomorphs, birds, tortoises, snakes and fish. The faunal remains from Contrebandiers Cave preserve surface modification that indicates both humans and carnivores acted as agents of prey accumulation. Skeletal element representation and surface modification of ungulate remains suggest that humans had primary access to small, medium and large-bodied prey. In the MSA levels, carnivore skeletal remains preserve surface modification that is interpreted as being indicative of behavior associated with skinning for fur removal.
The vertebrate faunal remains from MIS 5e and 5d indicate that humans were hunting grazers and mixed feeders from open habitats and suids from mixed habitats. The faunal remains from MIS 5c indicate that humans focused less on suids and more on mixed feeders from open habitats. The vertebrate faunal remains from MIS 2 reveal humans hunting grazers from dry, open habitats. This research provides a description of human hunting behavior in North Africa, and contributes to our understanding of early modern human behavior prior to dispersal out of Africa.
ContributorsHallett, Emily Yuko (Author) / Marean, Curtis W (Thesis advisor) / Reed, Kaye E (Committee member) / Dibble, Harold L. (Committee member) / Arizona State University (Publisher)
Created2018
Description
This work explores the underlying dynamics of democracies in the context of underdevelopment, arguing that when society has not attained a substantial degree of economic independence from the state, it undermines democratic quality and stability. Economic underdevelopment and political oppression are mutually reinforcing, and both are rooted in the structure of the agriculture sector, the distribution of land, and the rural societies that emerge around this order. These systems produce persistent power imbalances that militate toward their continuance, encourage dependency, and foster the development of neopatrimonialism and corruption in the government, thereby weakening key pillars of democracy such as accountability and representativeness. Through historical analysis of a single case study, this dissertation demonstrates that while this is partly a result of actor choices at key points in time, it is highly influenced by structural constraints embedded in earlier time periods. I find that Ghana’s historical development from the colonial era to present day closely follows this trajectory.
ContributorsEllis, Alicia N (Author) / Thies, Cameron (Thesis advisor) / Warner, Carolyn (Committee member) / Thomson, Henry (Committee member) / Arizona State University (Publisher)
Created2019
Description
Development throughout the course of history has traditionally resulted in the demise of biodiversity. As humans strive to develop their daily livelihoods, it is often at the expense of nearby wildlife and the environment. Conservation non-governmental organizations (NGOs), among other actors in the global agenda, have blossomed in the past century with the realization that there is an immediate need for conservation action. Unlike government agencies, conservation NGOs have an independent, potentially more objective outlook on procedures and policies that would benefit certain regions or certain species the most. They often have national and international government support, in addition to the credibility and influencing power to sway policy decisions and participate in international agendas. The key to their success lies in the ability to balance conservation efforts with socioeconomic development efforts. One cannot occur without the other, but they must work in coordination. This study looks at the example of African Great Apes. Eight ape-focused NGOs and three unique case studies will be examined in order to describe the impact that NGOs have. Most of these NGOs have been able to build the capacity from an initial conservation agenda, to incorporating socioeconomic factors that benefit the development of local communities in addition to the apes and habitat they set out to influence. This being the case, initiatives by conservation NGOs could be the key to a sustainable future in which humans and biodiversity coexist harmoniously.
ContributorsPrickett, Laura (Author) / Parmentier, Mary Jane (Thesis advisor) / Zachary, Gregg (Committee member) / Gerber, Leah (Committee member) / Arizona State University (Publisher)
Created2019
Description
This paper will focus on the changes in China's OFDI while also explaining its growth. However, another primary focus will be comparing the relationships between China, Hong Kong, and Africa. This paper will show the correlating changes between the three regions and explain the distribution of China's investments. One argument is that Hong Kong may play a large role in facilitating Chinese investment into Africa, which if not disaggregated, could lead to inaccurate numbers of China's FDI into Africa. The purpose of this paper is to investigate the importance of China's relationship with Hong Kong and Africa. In 2012, Garth Shelton argued that Hong Kong was an important gateway in South Africa's trade with China. Since then, many others have made similar claims in support of Hong Kong's bigger role. However, due to the difficulty of finding specific data for each region, these analyses are incomplete and fail to clearly substantiate their theory. I will try to find a correlation by gathering my own data, tables, and through different interviews.
ContributorsSon, James (Author) / Simonson, Mark (Thesis director) / Iheduru, Okechukwu (Committee member) / Economics Program in CLAS (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Sickle cell disease is a genetic disorder that can cause substantial helath problems. It is the result of a mutation in the DNA coding for hemoglobin. As a result of changes in two important amino acids, a person suffering from sickle cell disease will have erythrocytes that do not maintain the typical biconcave shape and instead for a crescent shape. Individuals with sickle cell disease may have many health problems tied to their irregular hemoglobin. The unusual shape of the erythrocytes leads to a much shorter cell life, which means that even though bone marrow remains active long past childhood to try to keep up with the loss of erythrocytes, the body is still unable to accommodate the rapid death of erythrocytes. The malformed erythrocytes can also cause vascular occlusion, blocking blood vessels and slowing blood flow. While sickle cell disease has the potential to spread worldwide, it is particularly common in Africa. This may be because people with the sickle cell trait have a high resistance to malaria, making them more likely to survive that ubiquitous disease and pass on their traits to their offspring. However, the mortality rate in young children with sickle cell disease is very high, in part because the spleen, already stressed by filtering out dead erythrocytes, has difficulties filtering out bacteria. One of the keys to stopping the spread of the disease is neonatal screening, but this requires specialized equipment that is fairly uncommon in rural areas, as can be seen in Kenya. Therefore, it would be highly beneficial to develop a more cost-effective and widely available method for testing for sickle cell disease.
ContributorsWold, John (Author) / Caplan, Michael (Thesis director) / LaBelle, Jeffrey (Committee member) / Snyder, Jan (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
Africa is the area of the largest economic water scarcity on earth, with multiple countries, political systems, and geographies involved. Additionally, water scarcity affects more countries in sub-Saharan African than anywhere else on earth, with consequences like waterborne diseases, loss of agricultural development, educational setbacks, and security threats. This thesis synthesizes data on the diverse geographies and politics involved in building a sustainable African water system. It presents historical and present technologies, costs, and problems implementing sustainable potable water solutions, and suggests regional differences and individualized solutions, pointing out advantages and disadvantages of damming, boreholes, open wells, open-source water, and sewer systems. It goes on to discuss grant programs for water and wastewater solutions and technologies. Finally it addresses two divergent, yet equally important data models for African water planning, combining their contributions in order to gain insight into the problem that neither alone can. The research overlaps aquifer and demographic data to see where water should be a priority in Africa. The author finds that hydrology as well as demographic data, when combined, point to the greatest water need in the Sahel. However, many growing cities are situated in areas with high aquifer levels making borehole technology some of the most economical as well as sustainable water sourcing. Recommendations include cultural humility, attention to political and environmental consequences of solutions, and cost-effective ways of addressing the lack of access to clean drinking water in Africa.
ContributorsBarbur, Denisa Teodora (Author) / Gaughan, Monica (Thesis director) / Hruschka, Daniel (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2014-05
Description
This paper is based on a research undertaking to understand China's presence in Africa and how this relates to Western relations with the continent. The research attempts to determine which option, Europe/US or the Chinese, may be the most suitable partner in development for Africa, as well as discuss what can be done to maximize the benefits, and mitigate the negative aspects of that relationship. A comparative analysis approach is used to judge the viability of each partner, and each is assessed according to a set of criteria, including the following: 1. Equitable and Respectful Relations 2. Maintenance of Sovereignty 3. Ability and Willingness to Finance Sustainable Development in Africa 4. Shared Experience and Understanding 5. Historical Element Drawing on the collected research presented in this document, the major finding is that the Chinese have a fundamentally different approach to aid and investment, and harbor conceptually distinctive ideas regarding development than the West. Based on the outcome of the comparative study against the above criteria, it is suggested that Africa may benefit from selecting China as a partner in achieving its own sustainable development, and suggestions are offered to effectively leverage this partnership.
ContributorsBoucher, Sara Alexandra (Author) / Aubrey, Lisa (Thesis director) / Li, Wei (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor) / School of Social Transformation (Contributor)
Created2014-05