Matching Items (2)
Filtering by
- Creators: Muthuswamy, Jitendran
Description
Optical Fibers coupled to laser light sources, and Light Emitting Diodes are the two classes of technologies used for optogenetic experiments. Arizona State University's Flexible Display Center fabricates novel flexible Organic Light Emitting Diodes(OLEDs). These OLEDs have the capability of being monolithically fabricated over flexible, transparent plastic substrates and having power efficient ways of addressing high density arrays of LEDs. This thesis critically evaluates the technology by identifying the key advantages, current limitations and experimentally assessing the technology in in-vivo and in-vitro animal models. For in-vivo testing, the emitted light from a flat OLED panel was directly used to stimulate the neo-cortex in the M1 region of transgenic mice expressing ChR2 (B6.Cg-Tg (Thy1-ChR2/EYFP) 9Gfng/J). An alternative stimulation paradigm using a collimating optical system coupled with an optical fiber was used for stimulating neurons in layer 5 of the motor cortex in the same transgenic mice. EMG activity was recorded from the contralateral vastus lateralis muscles. In vitro testing of the OLEDs was done in primary cortical neurons in culture transfected with blue light sensitive ChR2. The neurons were cultured on a microelectrode array for taking neuronal recordings.
ContributorsShah, Ankur (Author) / Muthuswamy, Jitendran (Thesis advisor) / Greger, Bradley (Committee member) / Blain Christen, Jennifer (Committee member) / Arizona State University (Publisher)
Created2015
Description
In this study, the engineers from biomedical engineering and electrical engineering researched and analyzed the components, uses, and processes for the brain and the Brain-Computer Interfaces (BCIs). They investigated the basics on the brain, the signals, and the overall uses of the devices. There have been many uses for electroencephalogram (EEG) signals, including prosthetics for patients after nerve injuries, cursor movements on a computer, moving vehicles, and many more projects. There are studies currently in progress and that will be in progress in the future that extend the uses of BCIs. The researchers in this thesis focused more on the processes the scientists used to approach the given problem. Some worked with patients to better his or her life, while others worked with volunteers to gain more knowledge of the brain and/or the BCIs. This thesis includes many different approaches for many unique projects. The analysis includes the location of the signal, the processing of the signal, the filtering of the signal, the transmission of the signal, and the movement of the device based on the signal. The current BCIs are not ready to be in patient’s daily lives, but the researchers are trying to create and perfect them in order to help as many patients as possible. As a biomedical engineer, the researchers in this thesis can apply the knowledge from the articles to solving potential problems in the future and further specific studies.
ContributorsKerlee, Jessica (Author) / Rodriguez, Armando (Thesis director) / Muthuswamy, Jitendran (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05