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- Genre: Masters Thesis
Description
Optical Fibers coupled to laser light sources, and Light Emitting Diodes are the two classes of technologies used for optogenetic experiments. Arizona State University's Flexible Display Center fabricates novel flexible Organic Light Emitting Diodes(OLEDs). These OLEDs have the capability of being monolithically fabricated over flexible, transparent plastic substrates and having power efficient ways of addressing high density arrays of LEDs. This thesis critically evaluates the technology by identifying the key advantages, current limitations and experimentally assessing the technology in in-vivo and in-vitro animal models. For in-vivo testing, the emitted light from a flat OLED panel was directly used to stimulate the neo-cortex in the M1 region of transgenic mice expressing ChR2 (B6.Cg-Tg (Thy1-ChR2/EYFP) 9Gfng/J). An alternative stimulation paradigm using a collimating optical system coupled with an optical fiber was used for stimulating neurons in layer 5 of the motor cortex in the same transgenic mice. EMG activity was recorded from the contralateral vastus lateralis muscles. In vitro testing of the OLEDs was done in primary cortical neurons in culture transfected with blue light sensitive ChR2. The neurons were cultured on a microelectrode array for taking neuronal recordings.
ContributorsShah, Ankur (Author) / Muthuswamy, Jitendran (Thesis advisor) / Greger, Bradley (Committee member) / Blain Christen, Jennifer (Committee member) / Arizona State University (Publisher)
Created2015
Description
A robotic swarm can be defined as a large group of inexpensive, interchangeable
robots with limited sensing and/or actuating capabilities that cooperate (explicitly
or implicitly) based on local communications and sensing in order to complete a
mission. Its inherent redundancy provides flexibility and robustness to failures and
environmental disturbances which guarantee the proper completion of the required
task. At the same time, human intuition and cognition can prove very useful in
extreme situations where a fast and reliable solution is needed. This idea led to the
creation of the field of Human-Swarm Interfaces (HSI) which attempts to incorporate
the human element into the control of robotic swarms for increased robustness and
reliability. The aim of the present work is to extend the current state-of-the-art in HSI
by applying ideas and principles from the field of Brain-Computer Interfaces (BCI),
which has proven to be very useful for people with motor disabilities. At first, a
preliminary investigation about the connection of brain activity and the observation
of swarm collective behaviors is conducted. After showing that such a connection
may exist, a hybrid BCI system is presented for the control of a swarm of quadrotors.
The system is based on the combination of motor imagery and the input from a game
controller, while its feasibility is proven through an extensive experimental process.
Finally, speech imagery is proposed as an alternative mental task for BCI applications.
This is done through a series of rigorous experiments and appropriate data analysis.
This work suggests that the integration of BCI principles in HSI applications can be
successful and it can potentially lead to systems that are more intuitive for the users
than the current state-of-the-art. At the same time, it motivates further research in
the area and sets the stepping stones for the potential development of the field of
Brain-Swarm Interfaces (BSI).
robots with limited sensing and/or actuating capabilities that cooperate (explicitly
or implicitly) based on local communications and sensing in order to complete a
mission. Its inherent redundancy provides flexibility and robustness to failures and
environmental disturbances which guarantee the proper completion of the required
task. At the same time, human intuition and cognition can prove very useful in
extreme situations where a fast and reliable solution is needed. This idea led to the
creation of the field of Human-Swarm Interfaces (HSI) which attempts to incorporate
the human element into the control of robotic swarms for increased robustness and
reliability. The aim of the present work is to extend the current state-of-the-art in HSI
by applying ideas and principles from the field of Brain-Computer Interfaces (BCI),
which has proven to be very useful for people with motor disabilities. At first, a
preliminary investigation about the connection of brain activity and the observation
of swarm collective behaviors is conducted. After showing that such a connection
may exist, a hybrid BCI system is presented for the control of a swarm of quadrotors.
The system is based on the combination of motor imagery and the input from a game
controller, while its feasibility is proven through an extensive experimental process.
Finally, speech imagery is proposed as an alternative mental task for BCI applications.
This is done through a series of rigorous experiments and appropriate data analysis.
This work suggests that the integration of BCI principles in HSI applications can be
successful and it can potentially lead to systems that are more intuitive for the users
than the current state-of-the-art. At the same time, it motivates further research in
the area and sets the stepping stones for the potential development of the field of
Brain-Swarm Interfaces (BSI).
ContributorsKaravas, Georgios Konstantinos (Author) / Artemiadis, Panagiotis (Thesis advisor) / Berman, Spring M. (Committee member) / Lee, Hyunglae (Committee member) / Arizona State University (Publisher)
Created2017
Description
The human brain controls a person's actions and reactions. In this study, the main objective is to quantify reaction time towards a change of visual event and figuring out the inherent relationship between response time and corresponding brain activities. Furthermore, which parts of the human brain are responsible for the reaction time is also of interest. As electroencephalogram (EEG) signals are proportional to the change of brain functionalities with time, EEG signals from different locations of the brain are used as indicators of brain activities. As the different channels are from different parts of our brain, identifying most relevant channels can provide the idea of responsible brain locations. In this study, response time is estimated using EEG signal features from time, frequency and time-frequency domain. Regression-based estimation using the full data-set results in RMSE (Root Mean Square Error) of 99.5 milliseconds and a correlation value of 0.57. However, the addition of non-EEG features with the existing features gives RMSE of 101.7 ms and a correlation value of 0.58. Using the same analysis with a custom data-set provides RMSE of 135.7 milliseconds and a correlation value of 0.69. Classification-based estimation provides 79% & 72% of accuracy for binary and 3-class classication respectively. Classification of extremes (high-low) results in 95% of accuracy. Combining recursive feature elimination, tree-based feature importance, and mutual feature information method, important channels, and features are isolated based on the best result. As human response time is not solely dependent on brain activities, it requires additional information about the subject to improve the reaction time estimation.
ContributorsChowdhury, Mohammad Samin Nur (Author) / Bliss, Daniel W (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Brewer, Gene (Committee member) / Arizona State University (Publisher)
Created2019