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- Creators: Adrian, Ronald
- Creators: Barrett, The Honors College
Description
A cerebral aneurysm is an abnormal ballooning of the blood vessel wall in the brain that occurs in approximately 6% of the general population. When a cerebral aneurysm ruptures, the subsequent damage is lethal damage in nearly 50% of cases. Over the past decade, endovascular treatment has emerged as an effective treatment option for cerebral aneurysms that is far less invasive than conventional surgical options. Nonetheless, the rate of successful treatment is as low as 50% for certain types of aneurysms. Treatment success has been correlated with favorable post-treatment hemodynamics. However, current understanding of the effects of endovascular treatment parameters on post-treatment hemodynamics is limited. This limitation is due in part to current challenges in in vivo flow measurement techniques. Improved understanding of post-treatment hemodynamics can lead to more effective treatments. However, the effects of treatment on hemodynamics may be patient-specific and thus, accurate tools that can predict hemodynamics on a case by case basis are also required for improving outcomes.Accordingly, the main objectives of this work were 1) to develop computational tools for predicting post-treatment hemodynamics and 2) to build a foundation of understanding on the effects of controllable treatment parameters on cerebral aneurysm hemodynamics. Experimental flow measurement techniques, using particle image velocimetry, were first developed for acquiring flow data in cerebral aneurysm models treated with an endovascular device. The experimental data were then used to guide the development of novel computational tools, which consider the physical properties, design specifications, and deployment mechanics of endovascular devices to simulate post-treatment hemodynamics. The effects of different endovascular treatment parameters on cerebral aneurysm hemodynamics were then characterized under controlled conditions. Lastly, application of the computational tools for interventional planning was demonstrated through the evaluation of two patient cases.
ContributorsBabiker, M. Haithem (Author) / Frakes, David H (Thesis advisor) / Adrian, Ronald (Committee member) / Caplan, Michael (Committee member) / Chong, Brian (Committee member) / Vernon, Brent (Committee member) / Arizona State University (Publisher)
Created2013
Effects of Aggregate Packing Density on the Mechanical Properties of Ultra-High Performance Concrete
Description
Cement is a remarkable construction material that allows for the formation of complex geometric forms while still providing adequate strength properties to be used as a structural material. This research focuses on Ultra-High Performance Concrete (UHPC) which is a specialized class of cementitious material that exhibits exceptional strength and durability properties when compared to standard concrete. UHPC achieves these properties through a combination of high cement content, high particle packing density, low water-to-cement ratio, and the additional of special admixtures such as superplasticizer. These components all serve the purpose of increasing UHPC strength and mechanical properties by helping achieve much high material densities than other forms of concrete.
In this study, aggregate material evaluation and testing was conducted for use in the mix design of the UHPC mixes that were carried out and tested. Each mix employed the same general UHPC mixture design with the only difference being the aggregate proportions of #4, #8, and #10 nominal size aggregates. The purpose of using a UHPC mix design that was independent of aggregate proportioning was to evaluate the effects of varying aggregate particle packing densities. Increased particle packing density of UHPC provide improved mechanical performance by decreasing the distance between particle within cured UHPC, thereby producing significant increases in compressive strength, tensile strength, durability, and service life of UHPC when compared to standard concrete. For this study, particle packing densities of 0.509, 0.521, 0.540, and 0.552 were employed and evaluated on the basis of compressive strength and tensile strength to determine the optimum UHPC mix design.
In this study, aggregate material evaluation and testing was conducted for use in the mix design of the UHPC mixes that were carried out and tested. Each mix employed the same general UHPC mixture design with the only difference being the aggregate proportions of #4, #8, and #10 nominal size aggregates. The purpose of using a UHPC mix design that was independent of aggregate proportioning was to evaluate the effects of varying aggregate particle packing densities. Increased particle packing density of UHPC provide improved mechanical performance by decreasing the distance between particle within cured UHPC, thereby producing significant increases in compressive strength, tensile strength, durability, and service life of UHPC when compared to standard concrete. For this study, particle packing densities of 0.509, 0.521, 0.540, and 0.552 were employed and evaluated on the basis of compressive strength and tensile strength to determine the optimum UHPC mix design.
ContributorsThornburg, Cody Michael (Author) / Neithalath, Narayanan (Thesis director) / Rajan, Subramaniam (Committee member) / Civil, Environmental and Sustainable Eng Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05