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- Creators: Dean, W.P. Carey School of Business
Description
Genistein, a compound found in soy that functions as a phytoestrogen, has been found to play a role in the body’s inflammatory response. By suppressing the expression of inflammatory genes and inhibiting tumor cell growth, genistein is thought to have both anti-inflammatory and cancer fighting properties. This study seeks to demonstrate genistein’s potential to mitigate the negative consequences of consuming a high fat diet specifically as it relates to increased inflammation and changes in the gut microbiome. Using an animal model, the study tested whether supplementing the mice’s diet with soy derived genistein would affect their serum IL-6 levels and the way in which their gut microbiomes responded to their high fat consumption. It was presumed that genistein supplementation would result in a less significant shift from the biomarkers tested in the control group and reduce the impact of the high fat diet. It was also hypothesized that consumption of the high fat diet would raise IL-6 levels and increase the presence of harmful bacteria in the test subjects.
ContributorsPettit, Gabrielle Sofia (Author) / Whisner, Dr. Corrie (Thesis director) / Al-Nakkash, Dr. Layla (Committee member) / Ortega Santos, Carmen (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
For my thesis, I researched the impact of the gut microbiome on people's lives. My thesis paper explains what the microbiome is, the microbiome-gut-brain axis, the effect of the standard American diet on the human microbiome, and why children might be the solution to fostering a more healthy and happy America. There is a direct connection between one's gut health and one's overall health and happiness. Since the microbiome influences many aspects of people's lives, it is important to take care of it and always protect it. Everything that people consume and expose themselves to will either enhance or destroy the gut microbiome. By bringing awareness of the importance of the gut microbiome to the general population and by providing better resources for Americans to cultivate a healthy microbiome, then more Americans will experience an overall greater quality of life.
ContributorsPascetti, Sarah (Author) / Hedges, Craig (Thesis director) / Fischer, Heidi (Committee member) / Trujillo, Rhett (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor) / College of Health Solutions (Contributor) / Industrial, Systems & Operations Engineering Prgm (Contributor)
Created2023-05