This thesis presents a systematic review of viruses found in the Peromyscus leucopus rodent species in North America. Various viruses cause serious illness in humans through contact with infected rodent urine, droppings, or saliva, or inhalation of dust contaminated with the virus, with Hantavirus pulmonary syndrome (HPS) being the most severe manifestation. Therefore, studying their distribution in rodent populations can inform public health interventions to reduce the risk of transmission. Through a literature review and data analysis, this study found that studying the distribution of viruses in rodents can help identify areas where humans may be at higher risk of contracting the virus, inform public health interventions to reduce the risk of HPS transmissions, and better understand the ecology of the virus and its host species, which can, in turn, inform conservation efforts. Furthermore, monitoring the spread of viruses over time and across regions can help us better understand their epidemiology and potential for future outbreaks, which can inform surveillance and response efforts to mitigate the impact of the virus on human and animal health. Overall, this study highlights the importance of interdisciplinary approaches in addressing complex public health and conservation issues and underscores the need for continued research in this area.