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In the current age of global climate crisis, corporations must confront the rising pressure to mitigate their environmental impacts. The goal of this research paper is to provide corporations with a resource to manage waste through the implementation of a circular economy and by increasing Corporate Social Responsibility (CSR). Navigating

In the current age of global climate crisis, corporations must confront the rising pressure to mitigate their environmental impacts. The goal of this research paper is to provide corporations with a resource to manage waste through the implementation of a circular economy and by increasing Corporate Social Responsibility (CSR). Navigating this large and complex system required the use of various methodologies including: the investigation of the relationships between waste management systems and sustainable development across major companies; literature reviews of scholarly articles about CSR, circular economies, recycling, and releases of company reports on sustainable development and financials. Lastly, interviews and a survey were conducted to gain deeper insight into the problems that make circular economies so difficult to achieve at scale.

ContributorsBird, Alex William (Author) / Heller, Cheryl (Thesis director) / Trujillo, Rhett (Committee member) / Department of Finance (Contributor) / Department of Management and Entrepreneurship (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Colorectal cancer is the third most common type of cancer that affects both men and women and the second leading cause of death in cancer related deaths[1, 2]. The most common form of treatment is chemotherapy followed by radiation, which is insufficient to cure stage four cancers[3]. Salmonella enteric has

Colorectal cancer is the third most common type of cancer that affects both men and women and the second leading cause of death in cancer related deaths[1, 2]. The most common form of treatment is chemotherapy followed by radiation, which is insufficient to cure stage four cancers[3]. Salmonella enteric has long been shown to have inherent tumor targeting properties and have been able to penetrate and exist in all aspects of the tumor environment, something that chemotherapy is unable to achieve. This lab has developed a genetically modified Salmonella typhimurium (GMS) which is able to deliver DNA vaccines or synthesized proteins directly to tumor sites. These GMS strains have been used to deliver human TNF-related apoptosis inducing ligand (TRAIL) protein directly to tumor sites, but expression level was limited. It is the hope of the experiment that codon optimization of TRAIL to S. typhimurium preferred codons will lead to increased TRAIL expression in the GMS. For preliminary studies, BALB/c mice were subcutaneously challenged with CT-26 murine colorectal cancer cells and treated with an intra-tumor injection with either PBS, strain GMS + PCMV FasL (P2), or strain GMS + Pmus FasL). APC/CDX2 mutant mice were also induced to develop human colon polyps and treated with either PBS, strain GMS + vector (P1), P2, or P3. The BALB/c mouse showed statistically significant levels of decreased tumor size in groups treated with P2 or P3. The APC/CDX2 mouse study showed statistically significant levels of decreased colon polyp numbers in groups treated with P3, as expected, but was not significantly significant for groups treated with P1 and P2. In addition, TRAIL was codon optimized for robust synthesis in Salmonella. The construct will be characterized and evaluated in vitro and in vivo. Hopefully, the therapeutic effect of codon optimized TRAIL will be maximal while almost completely minimizing any unintended side effects.
ContributorsCrawford, Courtney Rose (Co-author) / Crawford, Courtney (Co-author) / Kong, Wei (Thesis director) / Shi, Yixin (Committee member) / Fu, Lingchen (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Microplastics are defined as small pieces of plastics that are less than five millimeters in size. These microplastics can vary in their appearance, are known to be harmful to aquatic life and can threaten life cycles of marine organisms because of their chemical make-up and the toxic additives used in

Microplastics are defined as small pieces of plastics that are less than five millimeters in size. These microplastics can vary in their appearance, are known to be harmful to aquatic life and can threaten life cycles of marine organisms because of their chemical make-up and the toxic additives used in their manufacture. Although small in size, it is hypothesized that microplastics can serve as an example of how human activities can alter ecosystems near and far. To investigate the implications and determine the potential impact of microplastics on a protected atoll’s ecosystems, red-footed booby (Sula sula) guano samples from six locations on Palmyra Atoll were acquired from North Carolina State University via The Nature Conservancy and were inspected for the presence of microplastics. Each of the guano samples were weighed and prepared via wet oxidation. Microplastic fibers were detected via stereoscope microscopy and analyzed for chemical composition via Raman spectroscopy. All six sampling locations within Palmyra Atoll contained microplastic fibers identified as polyethylene terephthalate, with North-South Causeway and Eastern Island having the highest average number of microplastic fibers found per gram of guano sample (n = 0.611). These data provide evidence that seabirds can serve as vectors for the spread of microplastic pollution. This research lends context to the widespread impact of plastic pollution and states possible implications of its presence in delicate ecosystems.
ContributorsAnderson, Alyssa Cerise (Author) / Lisenbee, Cayle (Thesis director) / Halden, Rolf (Committee member) / Rolsky, Charles (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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The prevalence of plastic products has exponentially grown over the past two decades. Single-use plastics are the largest source of plastic waste in the environment and are heavily produced for both food and drink packaging. While it is argued that single-use plastics maintain product longevity and are associated with ‘ease

The prevalence of plastic products has exponentially grown over the past two decades. Single-use plastics are the largest source of plastic waste in the environment and are heavily produced for both food and drink packaging. While it is argued that single-use plastics maintain product longevity and are associated with ‘ease of use’, this research paper questions their essentiality.

In this study, single-use plastics in the food packaging industry were systematically reviewed in order to determine their ‘essentiality’ for product longevity. Four grocery stores were chosen and their brands ‘in plastic’ and ‘not in plastic’ were counted. Seven subcategories of food and drink types were created such that a proportion was representative of the brands in plastic per category.

The results of the systematic review showed that the majority of categories sampled from in each store had at least 80% of their brands in plastic packaging. Across four of the seven subcategories, 99-100% of each stores’ brands were in plastic packaging. Furthermore, six alternatives to single-use plastic packaging were reviewed and compared to current methods of food and drink packaging. This comparison deemed that none of the single-use packaging methods utilized in grocery stores were considered essential.

While this study concluded that none of the single-use plastics reviewed were deemed essential, alternatives still remain at a higher cost of production. Further innovation and widespread production of safe alternatives are both integral factors in reducing plastic production and protecting the future of the environment.
ContributorsGolda, Ashleigh Marie (Co-author) / Golda, Ashleigh (Co-author) / Polidoro, Beth (Thesis director) / Priest, Maura (Committee member) / Historical, Philosophical & Religious Studies (Contributor) / School of Social Transformation (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description

Plastic pollution is undoubtedly one of the most pressing challenges facing humanity today. Significant action is required in order to properly address this rapidly growing threat. The Circular Economy provides a promising model for solution design in terms of responsible consumption and production. Countdown: Circular Economy Solutions is an organization

Plastic pollution is undoubtedly one of the most pressing challenges facing humanity today. Significant action is required in order to properly address this rapidly growing threat. The Circular Economy provides a promising model for solution design in terms of responsible consumption and production. Countdown: Circular Economy Solutions is an organization created by Jasmine Amoako-Agyei focused on addressing the threat of plastic pollution in the United States and Ghana, West Africa. The first part of this report will explain the severity of the global plastic pollution crisis and challenges with recycling. It will then present the Circular Economy as a viable model for a course of action. From there it will explain the efforts of Countdown: Circular Economy Solutions over the last two with a pathway forward. This venture leveraged the greater ASU ecosystem of resources such as Walton Sustainability Solutions, Precious Plastic ASU, the Luminosity Lab, Changemaker Central, Venture Devils, Engineering Projects in Community Service (ASU), Gary K. Herberger Young Scholars Academy, KNUST, and Ashesi D: Lab.

ContributorsAmoako-Agyei, Jasmine (Author) / Phelan, Pat (Thesis director) / Cho, Steve (Thesis director) / Loughman, Joshua (Committee member) / Barrett, The Honors College (Contributor) / Tech Entrepreneurship & Mgmt (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Sustainability (Contributor)
Created2022-12
Description

Synthetic plastics are ubiquitously used in a broad range of applications, including food and drink packaging. Plastics often contain chemical additives, including bisphenols, phthalates, and terephthalic acid, which can degrade under thermal stress. The environmental presence of these chemicals is cause for public concern, especially in consumer products that utilize

Synthetic plastics are ubiquitously used in a broad range of applications, including food and drink packaging. Plastics often contain chemical additives, including bisphenols, phthalates, and terephthalic acid, which can degrade under thermal stress. The environmental presence of these chemicals is cause for public concern, especially in consumer products that utilize plastic packaging, as many have been identified as endocrine disruptors. This study sought to determine exposure to phthalates, bisphenols, and terephthalic acid by quantifying a broad spectrum of these analytes within three bottled water brands at varying temperature exposure levels using the combination of solid phase extraction followed by isotope dilution liquid chromatography-tandem mass spectrometry. Monobenzyl phthalate was detected in two of the three brands after bottles were heated to ~100 °C, ranging from 98 – 107 ng/L, and bisphenol A was detected in one brand at ~100 °C at an average concentration of 748 ± 36 ng/L. Subsequent mass loading calculations demonstrated that bioaccumulation of BPA from Brand C after high levels of temperature exposure well exceeded the tolerable daily intake (TDI). Findings in this study indicate that consumers should not be expected to incur harmful exposures to the target compounds under normal conditions as analytes were not measured in water bottle samples at 25 °C or 60 °C. Further studies should explore a more nuisance approach to heating over long durations, including that of ultraviolet exposure.

ContributorsZevitz, Jacob (Author) / Halden, Rolf (Thesis director) / Driver, Erin (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor)
Created2022-12
Description
The production and incineration of single-use micropipette tips and disposable gloves, which are heavily used within laboratory facilities, generate large amounts of greenhouse gasses (GHGs) and accelerate climate change. Plastic waste that is not incinerated often is lost in the environment. The long degradation times associated with this waste exacerbates

The production and incineration of single-use micropipette tips and disposable gloves, which are heavily used within laboratory facilities, generate large amounts of greenhouse gasses (GHGs) and accelerate climate change. Plastic waste that is not incinerated often is lost in the environment. The long degradation times associated with this waste exacerbates a variety of environmental problems such as substance runoff and ocean pollution. The objective of this study was to evaluate the efficacy of possible solutions for minimizing micropipette tip and disposable glove waste within laboratory spaces. It was hypothesized that simultaneously implementing the use of micropipette tip washers (MTWs) and energy-from-glove-waste programs (EGWs) would significantly reduce (p < 0.05) the average combined annual single-use plastic micropipette tip and nitrile glove waste (in kg) per square meter of laboratory space in the United States. ASU’s Biodesign Institute (BDI) was used as a case study to inform on the thousands of different laboratory facilities that exist all across the United States. Four separate research laboratories within the largest public university of the U.S. were sampled to assess the volume of plastic waste from single-use micropipette tips and gloves. Resultant data were used to represent the totality of single-use waste from the case study location and then extrapolated to all laboratory space in the United States. With the implementation of EGWs, annual BDI glove waste is reduced by 100% (0.47 ± 0.26 kg/m2; 35.5 ± 19.3 metric tons total) and annual BDI glove-related carbon emissions are reduced by ~5.01% (0.165 ± 0.09 kg/m2; 1.24 ± 0.68 metric tons total). With the implementation of MTWs, annual BDI micropipette tip waste is reduced by 92% (0.117 ± 0.03 kg/m2; 0.88 ± 0.25 metric tons total) and annual BDI tip-related carbon emissions are reduced by ~83.6% (4.04 ± 1.25 kg/m2; 30.5 ± 9.43 metric tons total). There was no significant difference (p = 0.06) observed between the mass of single-use waste (kg) in the sampled laboratory spaces before (x̄ = 47.1; σ = 43.3) and after (x̄ =0.070; σ = 0.033) the implementation of the solutions.When examining both solutions (MTWs & EGWs) implemented in conjunction with one another, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$7.92 ± $9.31/m2 (7,500 m2 of total wet laboratory space) or ~$60,000 ± $70,000 total. These savings represent ~15.77% of annual BDI spending on micropipette tips and nitrile gloves. The large error margins in these financial estimates create high uncertainty for whether or not BDI would see net savings from implementing both solutions simultaneously. However, when examining the implementation of only MTWs, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$12.01 ± $6.79 kg/m2 or ~$91,000 ± $51,200 total. These savings represent ~23.92% of annual BDI spending on micropipette tips and nitrile gloves. The lower error margins for this estimate create a much higher likelihood of net savings for BDI. Extrapolating to all laboratory space in the United States, the total annual amount of plastic waste avoided with the implementation of the MTWs was identified as 8,130 ± 2,290 tons or 0.023% of all solid plastic waste produced in the United States in 2018. The total amount of nitrile waste avoided with the implementation of the EGWs was identified as 32,800 ± 17,900 tons or 0.36% of all rubber solid waste produced in the United States in 2018. The total amount of carbon emissions avoided with the implementation of the MTWs was identified as 281,000 ± 87,000 tons CO2eq or 5.4*10-4 % of all CO2eq GHG emissions produced in the United States in 2020. Both the micropipette tip washer and the glove waste avoidance program solutions can be easily integrated into existing laboratories without compromising the integrity of the activities taking place. Implemented on larger scales, these solutions hold the potential for significant single-use waste reduction.
ContributorsMahant, Akhil (Author) / Zdrale, Gabriel (Co-author) / Halden, Rolf (Thesis director) / Biyani, Nivedita (Committee member) / Driver, Erin (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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Description

The cosmetic industry utilizes plastic for most of its packaging, as it is a cheap option that produces packaging that is highly durable and resistant to many chemicals. Polyethylene terephthalate (PET) is the most commonly used plastic in cosmetic packaging, and is an ideal candidate for recycling due to their

The cosmetic industry utilizes plastic for most of its packaging, as it is a cheap option that produces packaging that is highly durable and resistant to many chemicals. Polyethylene terephthalate (PET) is the most commonly used plastic in cosmetic packaging, and is an ideal candidate for recycling due to their short lifespan and low diffusion coefficient. However, cosmetic packaging is often not recycled properly due to its small size, contributing to the growing global plastic waste problem. If a sustainable closed-loop system was created where cosmetic packaging was created using purely recycled PET, then the amount of plastic produced could be reduced. By examining the mechanical properties of recycled composite PET from the cosmetic industry, conclusions can be drawn about its applicability in cosmetic packaging. The water absorption, UV-visible absorbance, and tensile strength was tested for recycled composite PET to predict how the material would perform if it was used in cosmetic packaging. It was found that the recycled composite PET did not perform as well as virgin PET in terms of water absorption and tensile strength, but performed similarly in reference to UV-visible absorbance. More research needs to be done to further characterize the mechanical properties of recycled composite PET before it can be used in cosmetic packaging, but this study analyzes three of the most prominent aspects found in cosmetic packaging.

ContributorsSoekardono, Nadya (Author) / Kuhn, Anthony (Thesis director) / Trujillo, Rhett (Committee member) / Machas, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Sustainability (Contributor) / School of Molecular Sciences (Contributor)
Created2022-05
Description
The post-industrial era ushered in significant advancements in global living standards, largely driven by technological innovations. The events of the 20th century shaped how these innovations implemented themselves into American culture, particularly influencing consumption habits. The broad shift to reliance on single use materials led to concerns about resource exploitation

The post-industrial era ushered in significant advancements in global living standards, largely driven by technological innovations. The events of the 20th century shaped how these innovations implemented themselves into American culture, particularly influencing consumption habits. The broad shift to reliance on single use materials led to concerns about resource exploitation and environmental sustainability. Recycling stands as a vital tool in mitigating these concerns, while maximizing sustainable goals and circular material life cycles. While recycling stands as an important concept in material reuse, the United States recycling infrastructure faces some major inefficiencies that prevent it from achieving its optimal benefits. Investigating the growth of curbside recycling and the consequences of China’s ban on recycling materials reveal failures within the recycling system. Once identified, further analysis of recycling failures emphasizes the use of concepts such as industrial ecology to visualize how industrial materials are influenced by broader multi-dimensional systems. One such level of analysis involves investigating the shortcomings of current recycling technologies and their implementation. However, to provide a fuller explanation of these inefficiencies, analysis of cultural, economic, and political dimensions is necessary. Case studies of recycling systems in different types of U.S. cities such as San Francisco and Surprise, provide insights into the effectiveness of these dimensions at highlighting core failures. Analysis of these failures also provides a framework in which to engineer possible solutions for recycling systems that emphasis the growth of cohesive recycling infrastructure and leveraging legislation to influence the recycling rates and the production of more renewable materials.
ContributorsJordan, Brendan (Author) / Boyer, Mackenzie (Thesis director) / Bronowitz, Jason (Committee member) / Barrett, The Honors College (Contributor) / School of Sustainable Engineering & Built Envirnmt (Contributor)
Created2023-12
Description

Plastic consumption has reached astronomical amounts. The issue is the single-use plastics that continue to harm the environment, degrading into microplastics that find their way into our environment. Finding sustainable, reliable, and safe methods to break down plastics is a complex but valuable endeavor. This research aims to assess the

Plastic consumption has reached astronomical amounts. The issue is the single-use plastics that continue to harm the environment, degrading into microplastics that find their way into our environment. Finding sustainable, reliable, and safe methods to break down plastics is a complex but valuable endeavor. This research aims to assess the viability of using biochar as a catalyst to break down polyethylene terephthalate (PET) plastics under hydrothermal liquefaction conditions. PET is most commonly found in single-use plastic water bottles. Using glycolysis as the reaction, biochar is added and assessed based on yield and time duration of the reaction. This research suggests that temperatures of 300℃ and relatively short experimental times were enough to see the complete conversion of PET through glycolysis. Further research is necessary to determine the effectiveness of biochar as a catalyst and the potential of process industrialization to begin reducing plastic overflow.

ContributorsWyatt, Olivia (Author) / Deng, Shuguang (Thesis director) / Jin, Kailong (Committee member) / Barrett, The Honors College (Contributor) / Chemical Engineering Program (Contributor)
Created2023-05