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- All Subjects: Alzheimer's Disease
- All Subjects: Choline
Description
Alzheimer’s Disease (AD) is the most prevalent form of dementia and is the sixth leading cause of death in the elderly. Evidence suggests that forms of stress, including prenatal maternal stress (PMS), could exacerbate AD development. To better understand the mechanism linking PMS and AD, we investigated behavior and specific epigenetic markers of the 3xTg-AD mouse model compared to aged-controls in offspring of stressed mothers and non-stressed mothers.
ContributorsBrookhouser, Leia (Author) / Coleman, Paul (Thesis director) / Velazquez, Ramon (Committee member) / Conrad, Cheryl (Committee member) / Judd, Jessica (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2022-12
Description
Alzheimer’s disease (AD) is projected to increase, and understanding risk and protective factors could help mitigate this increase. Deficits in Choline, a B-like vitamin, intake or issues with endogenous choline production can lead to an increased risk for AD development. To better understand the effects of endogenous choline through the lifespan in the context of Alzheimer pathology, Male and Female 3xTg-AD and NonTg mice, were aged to 16.81 ± 0.13 months. Body weight, food consumption data, and blood plasma samples were collected across the lifespan. A behavioral battery, that consisted of Rotarod, Elevated Plus Maze, and Intellicage, was performed to assess differences across a range of tasks. Hippocampal and cortical tissue were collected to assess pathology. Overall, 3xTg-AD mice had lower choline levels than NonTg at multiple timepoints and Males had higher choline than Females. Furthermore, 3xTg-AD Females had higher levels of both Aβ and Tau pathology than their Male counterparts. In the Intellicage, Females made fewer Percent of Correct Responses during Place Preference. Together these findings show that choline levels through the lifespan, impact the severity of pathology between Males and Female 3xTg-AD mice and behavioral differences between the 3xTg-AD and NonTg mouse models.
ContributorsMistry, Faizan (Author) / Velazquez, Ramon (Thesis director) / Judd, Jessica (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / School of Life Sciences (Contributor)
Created2024-05