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Description
The apolipoprotein E (APOE) e4 genotype is the most prevalent known genetic risk factor for Alzheimer's disease (AD). In this paper, we examined the longitudinal effect of APOE e4 on hippocampal morphometry in Alzheimer's Disease Neuroimaging Initiative (ADNI). Generally, atrophy of hippocampus has more chance occurs in AD patients who carrying the APOE e4 allele than those who are APOE e4 noncarriers. Also, brain structure and function depend on APOE genotype not just for Alzheimer's disease patients but also in health elderly individuals, so APOE genotyping is considered critical in clinical trials of Alzheimer's disease. We used a large sample of elderly participants, with the help of a new automated surface registration system based on surface conformal parameterization with holomorphic 1-forms and surface fluid registration. In this system, we automatically segmented and constructed hippocampal surfaces from MR images at many different time points, such as 6 months, 1- and 2-year follow up. Between the two different hippocampal surfaces, we did the high-order correspondences, using a novel inverse consistent surface fluid registration method. At each time point, using Hotelling's T^2 test, we found significant morphological deformation in APOE e4 carriers relative to noncarriers in the entire cohort as well as in the non-demented (pooled MCI and control) subjects, affecting the left hippocampus more than the right, and this effect was more pronounced in e4 homozygotes than heterozygotes.
ContributorsLi, Bolun (Author) / Wang, Yalin (Thesis advisor) / Maciejewski, Ross (Committee member) / Liang, Jianming (Committee member) / Arizona State University (Publisher)
Created2015
Description
It is important for organizations and businesses to have some kind of online presence, as there are enormous benefits, including utilizing the power of web languages to provide services for people. However, creating a website is difficult, and often expensive. While successful businesses can use their profits to develop a costly website, organizations are not so lucky and can't afford to pay large amounts of money for theirs. Thus, the goal of this project was to provide a complete website to the Card Trick Quilters organization found in Show Low, Arizona. The website serves as both a learning experience, to see exactly what it takes to construct a website from the ground up, and a service project that will provide the Card Trick Quilters with a website that performs various services for its members, with functionality that is completely unique to the Arizona quilting community at large. The creation of the website required learning several different skills in regards to web design, such as databases, scripting languages, and even elements of graphic design. The uniqueness of the website comes from the creation of an online submission form for the annual quilt show hosted by the quilters, and an email reminder system where members of the community can submit their addresses and receive emails when there is an upcoming meeting. While there will no doubt be changes and improvements to the website in the future, the website is currently live and ready for the community to use.
ContributorsSchwarting, Jessa Lynn (Author) / Balasooriya, Janaka (Thesis director) / Nakamura, Mutsumi (Committee member) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor) / School of Computing, Informatics, and Decision Systems Engineering (Contributor)
Created2016-05
Description
Palliative care is a field that serves to benefit enormously from the introduction of mobile medical applications. Doctors at the Mayo Clinic intend to address a reoccurring dilemma, in which palliative care patients visit the emergency room during situations that are not urgent or life-threatening. Doing so unnecessarily drains the hospital’s resources, and it prevents the patient’s physician from applying specialized care that would better suit the patient’s individual needs. This scenario is detrimental to all involved. A mobile medical application seeks to foster doctor-patient communication while simultaneously decreasing the frequency of these excessive E.R. visits. In order to provide a sufficient standard of usefulness and convenience, the design of such a mobile application must be tailored to accommodate the needs of palliative care patients. Palliative care is focused on establishing long-term comfort for people who are often terminally-ill, elderly, handicapped, or otherwise severely disadvantaged. Therefore, a UI intended for palliative care patients must be devoted to simplicity and ease of use. The application must also be robust enough that the user feels that they have been provided with enough capabilities. The majority of this paper is dedicated to overhauling an existing palliative care application, the product of a previous honors thesis project, and implementing a user interface that establishes a simple, positive, and advantageous environment. This is accomplished through techniques such as color-coding, optimizing page layout, increasing customization capabilities, and more. Above all else, this user interface is intended to make the patient’s experience satisfying and trouble-free. They should be able to log in, navigate the application’s features with a few taps of their finger, and log out — all without undergoing any frustration or difficulties.
ContributorsWilkes, Jarrett Matthew (Co-author) / Ganey, David (Co-author) / Dao, Lelan (Co-author) / Balasooriya, Janaka (Thesis director) / Faucon, Christophe (Committee member) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12
Description
As computers become a more embedded aspect of daily life, the importance of communicating ideas in computing and technology to the general public has become increasingly apparent. One such growing technology is electronic voting. The feasibility of explaining electronic voting protocols was directly investigated through the generation of a presentation based on journal articles and papers identified by the investigator. Extensive use of analogy and visual aids were used to explain various cryptographic concepts. The presentation was then given to a classroom of ASU freshmen, followed by a feedback survey. A self-evaluation on the presentation methods is conducted, and a procedure for explaining subjects in computer science is proposed based on the researcher's personal process.
ContributorsReniewicki, Peter Josef (Author) / Bazzi, Rida (Thesis director) / Childress, Nancy (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Visual Question Answering (VQA) is an increasingly important multi-modal task where models must answer textual questions based on visual image inputs. Numerous VQA datasets have been proposed to train and evaluate models. However, existing benchmarks exhibit a unilateral focus on textual distribution shifts rather than joint shifts across modalities. This is suboptimal for properly assessing model robustness and generalization. To address this gap, a novel multi-modal VQA benchmark dataset is introduced for the first time. This dataset combines both visual and textual distribution shifts across training and test sets. Using this challenging benchmark exposes vulnerabilities in existing models relying on spurious correlations and overfitting to dataset biases. The novel dataset advances the field by enabling more robust model training and rigorous evaluation of multi-modal distribution shift generalization. In addition, a new few-shot multi-modal prompt fusion model is proposed to better adapt models for downstream VQA tasks. The model incorporates a prompt encoder module and dual-path design to align and fuse image and text prompts. This represents a novel prompt learning approach tailored for multi-modal learning across vision and language. Together, the introduced benchmark dataset and prompt fusion model address key limitations around evaluating and improving VQA model robustness. The work expands the methodology for training models resilient to multi-modal distribution shifts.
ContributorsJyothi Unni, Suraj (Author) / Liu, Huan (Thesis advisor) / Davalcu, Hasan (Committee member) / Bryan, Chris (Committee member) / Arizona State University (Publisher)
Created2023
Description
Culturally responsive teaching refers to an approach to teaching and learning that facilitates the achievement of all students by including content that is relatable to all cultures, and creating a culturally-supported and learner-centered environment. The CSE 110 course at ASU would greatly benefit from the incorporation of culturally relevant learning, as it would help them thrive in their chosen field of study while being able to uphold and value cultural relevance. The incorporation of culturally relevant pedagogy would further help students from marginalized communities feel more accepted and capable to thrive in STEM education.
We began our research by first understanding the foundations of culturally responsive pedagogy, including how it is currently being used in classrooms. Concurrently, we studied the CSE 110 curriculum to see where we can implement this teaching strategy. Our research helped us develop a set of worksheets. In the second semester of our research we distributed these worksheets and a set of control worksheets. Students were randomly assigned to an experiment or control group each of the four weeks of the study. We then analyzed this information to quantitatively see how culturally responsive pedagogy affects their outcomes. To follow up we also conducted a survey to get some qualitative feedback about student experience. Our final findings consisted of an analysis on how culturally responsive pedagogy affects learning outcomes in an introductory computer science course.
ContributorsTripathi, Tejal (Author) / Mane, Rhea (Co-author) / Sathe, Isha (Co-author) / Tadayon-Navabi, Farideh (Thesis director) / Nkrumah, Tara (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2024-05
DescriptionCreating a Scheme Dialect using Modern C++.
ContributorsAl-Qassas, Feras (Author) / Osburn, Steve (Thesis director) / Chen, Yinong (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2024-05