Matching Items (26)
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Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the

Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
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Description
Opioid use in the United States is skyrocketing. Overdose deaths have increased 433% in

the last decade and will continue climbing. In addition to the mortality caused by illicit

opioid misuse, morbidity rates have also risen. People Who Inject Drugs (PWID)

demonstrate higher rates of Human Immunodeficiency Virus (HIV), Hepatitis C Virus

(HCV), Endocarditis,

Opioid use in the United States is skyrocketing. Overdose deaths have increased 433% in

the last decade and will continue climbing. In addition to the mortality caused by illicit

opioid misuse, morbidity rates have also risen. People Who Inject Drugs (PWID)

demonstrate higher rates of Human Immunodeficiency Virus (HIV), Hepatitis C Virus

(HCV), Endocarditis, Persistent Abscesses, Staphylococcus Aureus (S. aureus, Staph)

and other skin infections. This thesis serves as (1) a systematic review of the differences

in health conditions experienced by PWID and (2) an examination of the trends in skin

and soft tissue infection from a small sample in Phoenix, Arizona. The author argues that

PWID suffer from an increased rate of comorbid conditions associated with substance

use. Targeted social work interventions could be useful in reducing the rates of disease

and their impact on the individual and community.
ContributorsCohen, William H (Author) / Mendoza, Natasha (Thesis advisor) / Wolfersteig, Wendy (Committee member) / McLoone, Claire (Committee member) / Arizona State University (Publisher)
Created2019
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Description
Prescription opioid abuse has become a serious national problem. To respond to the opioid epidemic, states have created prescription drug monitoring programs (PDMPs) to monitor and reduce opioids use. We conducted a systematic literature review to better understand metrics used to quantify the effect that PDMPs have had on reducing

Prescription opioid abuse has become a serious national problem. To respond to the opioid epidemic, states have created prescription drug monitoring programs (PDMPs) to monitor and reduce opioids use. We conducted a systematic literature review to better understand metrics used to quantify the effect that PDMPs have had on reducing opioid abuse, and solutions and challenges related to the integration of PDMPs with EHRs. Lessons learned can help guide federal and state-based efforts to better respond to the current opioid crisis.
ContributorsPonnapalli, Aditya Somayajulu (Author) / Murcko, Anita (Thesis director) / Grando, Adela (Committee member) / Wertheim, Pete (Committee member) / Biomedical Informatics Program (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description
There has been a rise in heroin use throughout the United States due to doctors increasingly prescribing painkillers to patients with chronic pain (Kanouse & Compton, 2015; Compton, Boyle, & Wargo, 2015). Individuals get addicted to painkillers and, when their doctor will no longer prescribe them, turn to alternative methods

There has been a rise in heroin use throughout the United States due to doctors increasingly prescribing painkillers to patients with chronic pain (Kanouse & Compton, 2015; Compton, Boyle, & Wargo, 2015). Individuals get addicted to painkillers and, when their doctor will no longer prescribe them, turn to alternative methods of relief; heroin is often their cheapest option (Kolodny, Courtwright, Hwang, Kreiner, Eadie, Clark, & Alexander 2015). Heroin users are three to four times more likely to die from overdose than other types of drug users (Darke & Hall, 2003). The purpose of this study is to determine the likelihood that heroin users successfully reenter the community upon release from prison in comparison to other types of drug users. There are several re-entry outcomes that can be considered “success”; this study measures success as an index of the quality of the returning offender’s familial relationships as well as recidivism. The data used for this analysis is the Serious and Violent Offender Reentry Initiative (SVORI). The sample consists of male offenders, aged 18 years and older, who have been convicted of and imprisoned for a serious or violent crime. Findings suggest familial social support does not have an effect on heroin use, but heroin use increases the risk of recidivism. These findings will provide a context for rehabilitation of heroin offenders and will launch future research focusing on the differences between heroin users and other types of drug users.
ContributorsGriffin, Amber (Author) / Wallace, Danielle (Thesis advisor) / Wright, Kevin (Committee member) / Chamberlain, Alyssa (Committee member) / Arizona State University (Publisher)
Created2016
Description

With the recent rise in opioid overdose and death1<br/><br/>, chronic opioid therapy (COT) programs using<br/>Center of Disease Control (CDC) guidelines have been implemented across the United States8<br/>.<br/>Primary care clinicians at Mayo Clinic initiated a COT program in September of 2017, during the<br/>use of Cerner Electronic Health Record (EHR) system. Study

With the recent rise in opioid overdose and death1<br/><br/>, chronic opioid therapy (COT) programs using<br/>Center of Disease Control (CDC) guidelines have been implemented across the United States8<br/>.<br/>Primary care clinicians at Mayo Clinic initiated a COT program in September of 2017, during the<br/>use of Cerner Electronic Health Record (EHR) system. Study metrics included provider<br/>satisfaction and perceptions regarding opioid prescription. Mayo Clinic transitioned its EHR<br/>system from Cerner to Epic in October 2018. This study aims to understand if provider perceptions<br/>about COT changed after the EHR transition and the reasons underlying those perceptions.

ContributorsPonnapalli, Sravya (Author) / Murcko, Anita (Thesis director) / Wallace, Mark (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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“Health and Wealthness” is a podcast where your hosts, Emily Weigel and Hanaa Khan, discuss pressing and trending topics about health and wealth that everyone should know about. Our thesis focuses primarily on the opioid epidemic - the science and business sides.

ContributorsWeigel, Emily Elizabeth (Co-author) / Khan, Hanaa (Co-author) / Olive, Foster (Thesis director) / Bonfiglio, Thomas (Committee member) / School of Accountancy (Contributor) / WPC Graduate Programs (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Health and Wealthness is a podcast where your hosts, Emily Weigel and Hanaa Khan discuss pressing and trending topics about health and wealth that everyone should know about. Our first four episodes focus on the opioid crisis. Both the science and healthcare sides. We then go on to talk about

Health and Wealthness is a podcast where your hosts, Emily Weigel and Hanaa Khan discuss pressing and trending topics about health and wealth that everyone should know about. Our first four episodes focus on the opioid crisis. Both the science and healthcare sides. We then go on to talk about burnout and mental health in a conversational episode.

ContributorsKhan, Hanaa S (Co-author) / Weigel, Emily (Co-author) / Olive, Foster (Thesis director) / Bonfiglio, Thomas (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

As the opioid epidemic continues to rise, so does the incidence of neonatal abstinence syndrome. Neonatal abstinence syndrome, or NAS, is a withdrawal condition that occurs when a fetus has been exposed to addictive drugs prior to birth, most commonly opioids. Newborns with NAS can experience a variety of symptoms

As the opioid epidemic continues to rise, so does the incidence of neonatal abstinence syndrome. Neonatal abstinence syndrome, or NAS, is a withdrawal condition that occurs when a fetus has been exposed to addictive drugs prior to birth, most commonly opioids. Newborns with NAS can experience a variety of symptoms at and after birth, including trembling, sleep problems, seizures, and vomiting. Women who use opioids during pregnancy have a much higher risk of their newborn developing NAS. If a woman is suspected of using drugs during her pregnancy, the newborn will likely be tested toxicologically for NAS or other exposure to drugs. There is debate about the procedures that are used to determine who is tested and who is not. Institutions are currently being left to make their own decisions about how newborn toxicology tests will be performed and who receives such tests. Unless a mother self-reports her use, a test may not be performed unless certain factors are observed. This leaves room for variation and inconsistency across the board. Guidelines have been created in some institutions regarding several indicators of drugs abuse during pregnancy. However, this is not consistent between institutions across the nation and allows for the possibility of misdiagnosis or the lack of one altogether. Standards should be implemented regarding these toxicology tests for newborns to ensure all cases of infants with NAS are identified and able to be treated. This paper will examine neonatal abstinence syndrome, how toxicology testing is performed in newborns, why standards should be implemented, and provide a comparison between an upcoming and a current method of testing in newborns for NAS.

ContributorsKreutzer, Aubrey (Author) / Montero-Quesada, Shirly (Thesis director) / Watanabe-Sailor, Karen (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2021-12
ContributorsMendoza, Daniel (Author) / Grando, Adela (Thesis director) / Scotch, Matthew (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor) / School of Life Sciences (Contributor)
Created2023-05
ContributorsMendoza, Daniel (Author) / Grando, Adela (Thesis director) / Scotch, Matthew (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor) / School of Life Sciences (Contributor)
Created2023-05