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Description
HIV continues to remain a global health issue, in particular in many low and middle-income countries. The World Health Organization (WHO) estimates that of the nearly 38 million HIV-1 positive individuals, 25% are unaware they are infected. Despite decades of research, a safe and effective preventative vaccine has yet to be produced. The HIV-1 envelope glycoprotein41 and the Gag structural protein have been identified to be particularly important in HIV-1 transcytosis and cytotoxic lymphocyte response, respectively. Enveloped virus-like particles (VLPs) consisting of Gag and a deconstructed form of glycoprotein (dgp41) comprising the membrane proximal external region (MPER), transmembrane domain and cytoplasmic tail may present a unique and safe way of presenting these proteins in a state mimicking their natural formation. Another form of presenting the immunogenic glycoprotein41, particularly the MPER component, is by presenting it onto the N-terminal of an IgG molecule, thereby creating an IgG fusion molecule. In our lab, both VLPs and IgG fusion molecules are highly expressed and purified within GnGn Nicotiana benthamiana. The results indicated that these recombinant proteins can be assembled properly within plants and can elicit an immune response in mice. This provides a preliminary step in using such Gag/dpg41 VLPs and RIC as present a safe, effective, and inexpensive HIV vaccine.
ContributorsGarcia, Izamar (Author) / Mor, Tsafrir (Thesis director) / Mason, Hugh (Committee member) / Kamzina, Aigerim (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
ContributorsSchildkret, David (Conductor) / Chamber Singers (Performer) / ASU Library. Music Library (Publisher)
Created2018-02-10
ContributorsGlenn, Erica (Conductor) / Evans, Bartlett R. (Conductor) / Oh, Eun-Mi (Conductor) / Thompson, Jason D. (Conductor) / Schildkret, David (Conductor) / Concert Choir (Performer) / Arizona Statesmen (Performer) / Women's Chorus (Performer) / Gospel Choir (Performer) / Barrett Choir (Performer) / Chamber Singers (Performer) / Choral Union (Performer) / ASU Library. Music Library (Publisher)
Created2017-11-30
ContributorsUniversity Choirs (Performer) / ASU Library. Music Library (Publisher)
Created2000-11-16
ContributorsSchildkret, David (Conductor) / White, Jamilyn (Performer) / Krison, Danielle (Performer) / Barefield, Robert (Performer) / FitzPatrick, Carole (Performer) / Chamber Singers (Performer) / Choral Union (Performer) / Symphonic Chorale (Performer) / University Symphony Orchestra (Performer) / ASU Library. Music Library (Publisher)
Created2007-04-26
ContributorsLyne, Gregory K. (Performer) / Stutzman, Gina (Performer) / Woodgate, Lyn (Performer) / Cornner, Charles B. (Performer) / Rozukalns, Andris L. (Performer) / Women's Choir (Performer) / University Choir (Performer) / ASU Library. Music Library (Publisher)
Created1996-11-24
ContributorsCherland, Carl (Performer) / Fuller, Charles L. (Performer) / O'Brien, Robert (Performer) / Hooper, Wm. John (Performer) / Graduate Chorale (Performer) / Recital Chorale (Performer) / ASU Library. Music Library (Publisher)
Created1987-10-01
ContributorsRoueche, Michelle (Performer) / Partin, Darrell (Performer) / Wiest-Parthun, Karen (Performer) / Harvison, Emery (Performer) / Hernandez, Rene (Performer) / Foley, Laura (Performer) / Women's Choir (Performer) / ASU Library. Music Library (Publisher)
Created1994-04-21
ContributorsParthun, Karen (Conductor) / Hickman, Miriam, 1955- (Performer) / University Choir (Performer) / Vocal Jazz Ensemble (Performer) / ASU Library. Music Library (Publisher)
Created2000-11-19
ContributorsPeterson, Craig C. (Director) / Butler, Robb (Director) / Forkner, Christina (Contributor) / Leman, Christi (Performer) / Miller, Kenny (Musician) (Performer) / Howard, Johnothon (Performer) / Gibson, Ted (Performer) / Herberger Singers (Performer) / University Choir (Performer) / ASU Library. Music Library (Publisher)
Created2003-10-12