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- Genre: Doctoral Dissertation
Description
Proprioception is the sense of body position, movement, force, and effort. Loss of proprioception can affect planning and control of limb and body movements, negatively impacting activities of daily living and quality of life. Assessments employing planar robots have shown that proprioceptive sensitivity is directionally dependent within the horizontal plane however, few studies have looked at proprioceptive sensitivity in 3d space. In addition, the extent to which proprioceptive sensitivity is modifiable by factors such as exogenous neuromodulation is unclear. To investigate proprioceptive sensitivity in 3d we developed a novel experimental paradigm employing a 7-DoF robot arm, which enables reliable testing of arm proprioception along arbitrary paths in 3d space, including vertical motion which has previously been neglected. A participant’s right arm was coupled to a trough held by the robot that stabilized the wrist and forearm, allowing for changes in configuration only at the elbow and shoulder. Sensitivity to imposed displacements of the endpoint of the arm were evaluated using a “same/different” task, where participant’s hands were moved 1-4 cm from a previously visited reference position. A measure of sensitivity (d’) was compared across 6 movement directions and between 2 postures. For all directions, sensitivity increased monotonically as the distance from the reference location increased. Sensitivity was also shown to be anisotropic (directionally dependent) which has implications for our understanding of the planning and control of reaching movements in 3d space.
The effect of neuromodulation on proprioceptive sensitivity was assessed using transcutaneous electrical nerve stimulation (TENS), which has been shown to have beneficial effects on human cognitive and sensorimotor performance in other contexts. In this pilot study the effects of two frequencies (30hz and 300hz) and three electrode configurations were examined. No effect of electrode configuration was found, however sensitivity with 30hz stimulation was significantly lower than with 300hz stimulation (which was similar to sensitivity without stimulation). Although TENS was shown to modulate proprioceptive sensitivity, additional experiments are required to determine if TENS can produce enhancement rather than depression of sensitivity which would have positive implications for rehabilitation of proprioceptive deficits arising from stroke and other disorders.
The effect of neuromodulation on proprioceptive sensitivity was assessed using transcutaneous electrical nerve stimulation (TENS), which has been shown to have beneficial effects on human cognitive and sensorimotor performance in other contexts. In this pilot study the effects of two frequencies (30hz and 300hz) and three electrode configurations were examined. No effect of electrode configuration was found, however sensitivity with 30hz stimulation was significantly lower than with 300hz stimulation (which was similar to sensitivity without stimulation). Although TENS was shown to modulate proprioceptive sensitivity, additional experiments are required to determine if TENS can produce enhancement rather than depression of sensitivity which would have positive implications for rehabilitation of proprioceptive deficits arising from stroke and other disorders.
ContributorsKlein, Joshua (Author) / Buneo, Christopher (Thesis advisor) / Helms-Tillery, Stephen (Committee member) / Kleim, Jeffrey (Committee member) / Santello, Marco (Committee member) / Arizona State University (Publisher)
Created2018
Description
In order to perceive the heaviness of an object, one must wield it. This requires muscle activity and its resulting movements. Research has shown that muscle activity and movement combine for this perception in a manner inspired by Newton’s 2nd Law of Motion. Research in this area has relied on specific movement and muscle activity measures that often capture one moment of a lift. The current set of experiments set out to determine which measures best capture the underlying phenomena that lead to heaviness perception during a lift. In the first experiment, participants lifted stimuli with an elbow flexion lift while their muscle activity and movement were recorded. Participants reported their perceived heaviness of the stimuli as soon as they reached it, which resulted in an average decision angle of around 30-degrees. In the second and third experiments, participants the same stimuli with the same elbow flexion lift in four perturbation conditions – they experienced perturbations at 15-degrees of the lift, 30-degrees, 45-degrees, and with no perturbation. In the second experiment, participants experienced a physical perturbation and a cognitive perturbation in the third experiment. Across Experiments 2 and 3, the pattern of results suggested that the more time participants have in a lift, the more proportion correct, muscle activity, and movement measures appears like they do in the no perturbation condition. Additionally, a logistic least absolute shrinkage and selection operator (LASSO) regression was used to determine which measures best predicted perception. Results show that the integrated electromyogram of the biceps brachii that occurs after peak acceleration (iEMG BB after pACC) and Average Acceleration, which are both measures that capture more than one point of a lift, predicted heaviness perception. A new model of heaviness perception was then developed, using these new measures. Comparing this New Model to an Original Model from Waddell et al., 2016 resulted in better prediction from the New Model – suggesting that measure that capture more of a lift better predict heaviness perception, meaning that an entire ongoing action event is important for perception.
ContributorsWaddell, Morgan Leigh (Author) / Amazeen, Eric L (Thesis advisor) / Amazeen, Polemnia G (Committee member) / Glenberg, Arthur M (Committee member) / Gray, Rob (Committee member) / Arizona State University (Publisher)
Created2021