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- All Subjects: Creative Project
Exploring Structure and Function of Human Cold Sensing Protein TRPM8 with ROSETTA Comparative Models
Description
Transient Receptor Potential (TRP) channels are a diverse class of ion channels notable as polymodal sensors. TRPM8 is a TRP channel implicated in cold sensation, nociception, and a variety of human diseases, including obesity and cancer. Despite sustained interest in TRPM8 since its discovery in 2001, many of the molecular mechanisms that underlie function are not yet clear. Knowledge of these properties could have implications for medicine and physiological understanding of sensation and signaling. Structures of TRP channels have proven challenging to solve, but recent Cryoelectron microscopy (Cryo-EM) structures of TRPV1 provide a basis for homology-based modeling of TRP channel structures and interactions. I present an ensemble of 11,000 Rosetta computational homology models of TRPM8 based on the recent Cryo-EM apo structure of TRPV1 (PDB code:3J5P). Site-directed mutagenesis has provided clues about which residues are most essential for modulatory ligands to bind, so the models presented provide a platform to investigate the structural basis of TRPM8 ligand modulation complementary to existing functional and structural information. Menthol and icilin appear to interact with interfacial residues in the sensor domain (S1-S4). One consensus feature of these sites is the presence of local contacts to the S4 helix, suggesting this helix may be mechanistically involved with the opening of the pore. Phosphatidylinositol 4,5-bisphosphate (PIP2)has long been known to interact with the C-terminus of TRPM8, and some of the homology models contain plausible binding pockets where PIP2 can come into contact with charged residues known to be essential for PIP2 modulation. Future in silico binding experiments could provide testable hypothesis for in vitro structural studies, and experimental data (e.g. distance constraints from electron paramagnetic resonance spectroscopy [EPR]) could further refine the models.
ContributorsHelsell, Cole Vincent Maher (Author) / Van Horn, Wade (Thesis director) / Wang, Xu (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2015-05
Description
"The Legal Adventures of Frankie and Rosie" is a creative project that explores the nontraditional format of comics to express creative nonfiction. The project is a set of 30 independent comics that focuses on two primary college-going students who are based off of the authors. The characters, Frankie and Rosie narrate their stories through dialogue. The authors use this narrative model to archive their college experience at ASU. Representing creative nonfiction through comics yields an amalgamated format that can be challenging for both the writers to produce as well as for the readers to consume. Ultimately, the project serves as an attempt to test whether or not the comic medium can stand by itself as an appropriate format to express creative nonfictional narratives without becoming a diluted combination of its purer predecessors.
ContributorsBennewitz, Dana (Co-author) / Ray, Payel (Co-author) / Martin, Thomas (Thesis director) / Scott Lynch, Jacquelyn (Committee member) / Civil, Environmental and Sustainable Engineering Programs (Contributor) / Barrett, The Honors College (Contributor) / School of Geographical Sciences and Urban Planning (Contributor) / Electrical Engineering Program (Contributor) / School of Social Transformation (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2015-05
Description
The title means nothing because the stories have little in common, aside from the fact that I wrote them. The common theme of anxiety was unintentional, though it is prevalent in the stories, poetry and my life. Each story is written from a different style, with a different interest in mind. The poetry that breaks up the stories is mine, and also free of common bonds. People whom I love inspired some of them; others stem from people with whom I was (or still am) angry. Some of them are just me trying to write poetry like other successful poets, who seem to know something I don't. I wrote this set of stories and poems because I wanted to see if I could do it. I wanted to challenge myself in a new medium (two new mediums really, if you separate literature and poetry). I wanted to prove to myself that I could do it, if I really set my mind to it. I wanted to have some wealth of words, which I could record myself reading. Overall, I hope that you enjoy these stories and words. I wrote them to entertain myself, and they seem to do that pretty well. If you don't like them, stop reading. If you do like them, keep reading and tell everyone you know about this collection. I'm proud of my work here, so anything beyond that is icing on my cake.
ContributorsRagatz, Zachariah Edward (Author) / Scott, Jason Davids (Thesis director) / Espinosa, Micha (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / School of Film, Dance and Theatre (Contributor)
Created2015-05
Description
Rainbow Connection is an integrated choir with members on and off the autism spectrum. It was founded in the spring of 2012 by Barrett students Ali Friedman, Megan Howell, and Victoria Gilman as part of an honors thesis creative project. Rainbow Connection uses the rehearsal process and other creative endeavors to foster natural relationship building across social gaps. A process-oriented choir, Rainbow Connection's main goals concern the connections made throughout the experience rather than the final musical product. The authors believe that individual, non-hierarchical relationships are the keys to breaking down systemized gaps between identity groups and that music is an ideal facilitator for fostering such relationships. Rainbow Connection operates under the premise that, like colors in a rainbow, choir members create something beautiful not by melding into one homogenous group, but by collaboratively showcasing their individual gifts. This paper will highlight the basic premise and structure of Rainbow Connection, outline the process of enacting the choir, and describe the authors' personal reactions and takeaways from the project.
ContributorsFriedman, Alexandra (Co-author) / Gilman, Victoria (Co-author) / Howell, Megan (Co-author) / Rio, Robin (Thesis director) / Schildkret, David (Committee member) / Barrett, The Honors College (Contributor) / School of Music (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2014-12
Description
We created an Android application, Impromp2, which allows users to search for and save events of interest to them in the Phoenix area. The backend, built on the Parse platform, gathers events daily using Web services and stores them in a database. Impromp2 was designed to improve upon similarly-purposed apps available for Android devices in several key ways, especially in user interface design and data interaction capability. This is a full-stack software project that explores databases and their performance considerations, Web services, user interface design, and the challenges of app development for a mobile platform.
ContributorsNorth, Joseph Robert (Author) / Balasooriya, Janaka (Thesis director) / Nakamura, Mutsumi (Committee member) / Faucon, Philippe (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2015-05
Description
Since the acceptance of Einstein's special theory of relativity by the scientific community, authors of science fiction have used the concept of time dilation to permit seemingly impossible feats. Simple spacecraft acceleration schemes involving time dilation have been considered by scientists and fiction writers alike. Using an original Java program based upon the differential equations for special relativistic kinematics, several scenarios for round trip excursions at relativistic speeds are calculated and compared, with particular attention to energy budget and relativistic time passage in all relevant frames.
ContributorsAlfson, Jonathan William (Author) / Jacob, Richard (Thesis director) / Covatto, Carl (Committee member) / Foy, Joseph (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Physics (Contributor)
Created2015-05
Description
TIME CLASH
by
Sam Gerkin
A Serialized Single-Camera Comedy for Streaming
For my Thesis, I wrote an original TV Pilot Script and a Series “bible”. In lieu of a defense, I wrote a paper about the process of writing the Pilot.
Defining Principle:
Though different people often have very different beliefs, we all must fight for the beliefs that hold a society together.
Logline:
Extremely different individuals from the past, present, and future must find a way to work together to save the universe from evil creatures in present-day Phoenix, Arizona.
by
Sam Gerkin
A Serialized Single-Camera Comedy for Streaming
For my Thesis, I wrote an original TV Pilot Script and a Series “bible”. In lieu of a defense, I wrote a paper about the process of writing the Pilot.
Defining Principle:
Though different people often have very different beliefs, we all must fight for the beliefs that hold a society together.
Logline:
Extremely different individuals from the past, present, and future must find a way to work together to save the universe from evil creatures in present-day Phoenix, Arizona.
ContributorsGerkin, Samuel (Co-author) / Gerkin, Sam (Co-author) / Maday, Gregory (Thesis director) / Bernstein, Gregory (Committee member) / School of Film, Dance and Theatre (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This creative project is a portfolio of accessible science communication. It consists of three multimedia texts, each one written and designed for a different audience about a different topic. The first project is an article/report about the recent launch delays and cost increases for the James Webb Space Telescope, written for adults in their 40s-50s. The second project is a children’s picture book about Einstein’s theory of general relativity, written for homeschoolers in 6th grade. The third project is an educational animated video about the difference between gravity waves and gravitational waves, written for students in 7th grade.
ContributorsShafer, Christiana (Author) / Wheeler, Jacqueline (Thesis director) / Foy, Joseph (Committee member) / Hannah, Mark (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Department of English (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
FastStat is a responsive website designed to work on any handheld, laptop, or desktop device. It serves as a first step into statistical calculations, educating the user on the basics of statistical analysis, and guiding them as they perform analyses of their own using built-in calculators. The calculators available can perform z tests, t tests, chi square tests, and analysis of variance tests to determine significant characteristics of the user's data. Outputted data includes means, standard deviations, significance levels, applicable statistics, and worded results indicating the outcome of the performed test. With its clean design, FastStat directs the user in an intuitive manner to fill in the information needed, giving clear indications of what types of values are needed where and flagging descriptive error messages if any inputted values are incorrect. FastStat also implements a halt to calculations if any errors are found, which saves time by avoiding impossible calculations. Once complete, FastStat outputs a variety of information of use to the user in a clearly labeled manner. The calculators are designed in such a way that the user will know what information they will get out of the calculator before performing any calculations at all. Aside from the calculators, FastStat includes introductory pages designed to get users familiar with common statistical terms and the associated tests, solidifying its purpose as an introductory tool. All tests are described by their typical uses, necessary inputs, calculated outputs, and extra notes of importance. Many terms are defined for the purpose of statistics, complete with examples to help educate the user on the concepts. With the information available, even the newest statistician can learn and begin performing tests almost immediately.
ContributorsBroin, Demetri Evan (Author) / Squire, Susan (Thesis director) / Samara, Marko (Committee member) / Graphic Information Technology (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
This creative project centers on creating evaluative writing about film, in the form of a film review blog. Preliminary writing was done, in which the distinction was made between critical film writing and movie reviewing, as well as an analysis of how film critics have honed in their criticism and what makes their content effective for their audience. The rest of the writing for this project consists of a total of 15 reviews for 15 different movies released in 2017 and 2018. In these reviews, there is a brief introduction of the plot and context in which the film is made, followed by an evaluative analysis of what made the film effective or ineffective in achieving its artistic goals. The reviews involve an amalgamation of the content and topics taught in the Film and Media Studies program at Arizona State University, from screenwriting to cinematography. This process of writing reviews and being edited by the Director and Second Reader allows for the opportunity to find a unique writing voice and create content that is accessible for the wide audience that would be reading the work. All of the writing completed for this project (except for the "My Favorite Film Critics" piece) is compiled together in a WordPress blog, in an easily readable and accessible format. The blog itself serves as a way to reach the desired audience, as well as entice them to engage with the writing and the films being written about. This includes providing images and trailers for each respective film, to add a visual component to the writing. The final product is a unique way to engage with the content taught in the Film and Media Studies program, while simultaneously building a portfolio of writing that will be expanded upon and continued in the future.
ContributorsPolich, Brennan Taylor (Author) / Green, Michael (Thesis director) / Bernstein, Gregory (Committee member) / Department of English (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05