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- All Subjects: medicine
- Creators: Kingsbury, Jeffrey
Our current understanding of the mitochondrial genome was revolutionized in 2015 with the discovery of short open reading frames (sORFs) that produced protein products called mitochondrial-derived peptides (MDPs). Interestingly, unlike other proteins produced by the organelle, these MDPs are not directly involved in the electron transport chain but rather serve the role of metabolic regulators. In particular, one of these peptides called MOTS-c has been shown to regulate glucose and fat metabolism in an AMPK-dependent manner. With its capacity to enter the mitochondria and impact gene expression, MOTS-c has also displayed the ability to increase aerobic exercise performance by triggering elevated synthesis of the HO-1 antioxidant. Overall these findings position MOTS-c as a promising treatment for metabolic diseases as well as a potential dietary supplement to boost ATP availability.
Medical recovery time continues to be a drawback for many medical diagnoses and procedures. Prolonged recovery affects all aspects of the population, and targets different avenues of everyday life. Avenues such as providing, attending a job, personal objectives in different ways and even their own well-being. To combat this one area of research that has gained tremendous awareness in recent years is that of platelet-rich fibrin (PRF), which has been utilized across a wide variety of medical fields for the regeneration of soft tissues. PRF, or platelet-rich fibrin, is the next generation treatment of platelet concentrate. PRF is a fibrin matrix composed of platelet cytokines, growth factors and cells used to help wound healing and tissue regeneration. The objective of this thesis is to investigate the potential recovery time difference with PRF incorporation for common medical procedures. The experimental group included three individuals who had PRF treatment at any point during any sort of medical operation. The control group included individuals who did not have PRF treatment at any point and also those who had no prior knowledge of this method of treatment. Results were mixed because of the variative behind the medical procedures. Through observation, PRF treatment improved tolerance of pain, well-being of patients and quality of recovery with three different domains of inquiry per patient testimony. This case-analysis of 6 patients is a preliminary study and therefore inconclusive. PRF is a promising approach and this study suggests that it could potentially be a new medical approach to treatment.