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- Genre: Masters Thesis
Description
This thesis explores concept of "global bioethics" in both its development as well as its current state in an effort to understand exactly where it fits into the larger field of bioethics. Further, the analysis poses specific questions regarding what it may contribute to this field and related fields, and the possibility and scope associated with the continued development of global bioethics as its own discipline. To achieve this, the piece addresses questions regarding current opinions on the subject, the authorities and their associated publications related to global bioethics, and what the aims of the subject should be given its current state. "Global Bioethics" is a term that, while seen frequently in bioethics literature, is difficult to define succinctly. While many opinions are provided on the concept, little consensus exists regarding its application and possible contributions and, in some cases, even its very possibility. Applying ethical principles of health and medicine globally is undoubtedly complicated by the cultural, social, and geographical considerations associated with understanding health and medicine in different populations, leading to a dichotomy between two schools of thought in relation to global bioethics. These two sides consist of those who think that universality of bioethics is possible whereas the opposing viewpoint holds that relativism is the key to applying ethics on a global scale. Despite the aforementioned dichotomy in addressing applications of global bioethics, this analysis shows that the goals of the subject should be more focused on contributing to ethical frameworks and valuable types of thinking related to the ethics health and medicine on a global scale. This is achieved through an exploration of bioethics in general, health as a function of society and culture, the history and development of global bioethics itself, and an exploration of pertinent global health topics. While primarily descriptive in nature, this analysis critiques some of the current discussions and purported goals surrounding global bioethics, recommending that the field focus on fostering valuable discussion and framing of issues rather than the pursuit of concrete judgments on moral issues in global health and medicine.
ContributorsRuffenach, Stephen Charles (Author) / Robert, Jason S (Thesis advisor) / Maienschein, Jane (Committee member) / Hruschka, Daniel J (Committee member) / Arizona State University (Publisher)
Created2011
Description
Infections caused by the Hepatitis C Virus (HCV) are very common worldwide, affecting up to 3% of the population. Chronic infection of HCV may develop into liver cirrhosis and liver cancer which is among the top five of the most common cancers. Therefore, vaccines against HCV are under intense study in order to prevent HCV from harming people's health. The envelope protein 2 (E2) of HCV is thought to be a promising vaccine candidate because it can directly bind to a human cell receptor and plays a role in viral entry. However, the E2 protein production in cells is inefficient due to its complicated matured structure. Folding of E2 in the endoplasmic reticulum (ER) is often error-prone, resulting in production of aggregates and misfolded proteins. These incorrect forms of E2 are not functional because they are not able to bind to human cells and stimulate antibody response to inhibit this binding. This study is aimed to overcome the difficulties of HCV E2 production in plant system. Protein folding in the ER requires great assistance from molecular chaperones. Thus, in this study, two molecular chaperones in the ER, calreticulin and calnexin, were transiently overexpressed in plant leaves in order to facilitate E2 folding and production. Both of them showed benefits in increasing the yield of E2 and improving the quality of E2. In addition, poorly folded E2 accumulated in the ER may cause stress in the ER and trigger transcriptional activation of ER molecular chaperones. Therefore, a transcription factor involved in this pathway, named bZIP60, was also overexpressed in plant leaves, aiming at up-regulating a major family of molecular chaperones called BiP to assist protein folding. However, our results showed that BiP mRNA levels were not up-regulated by bZIP60, but they increased in response to E2 expression. The Western blot analysis also showed that overexpression of bZIP60 had a small effect on promoting E2 folding. Overall, this study suggested that increasing the level of specific ER molecular chaperones was an effective way to promote HCV E2 protein production and maturation.
ContributorsHong, Fan (Author) / Mason, Hugh (Thesis advisor) / Gaxiola, Roberto (Committee member) / Chang, Yung (Committee member) / Chen, Qiang (Committee member) / Arizona State University (Publisher)
Created2011
Description
In recent years, the length of time people use and keep belongings has decreased. With the acceptance of short-lived furniture and inexpensive replacements, the American mentality has shifted to thinking that discarding furniture is normal, often in the guise of recycling. Americans are addicted to landfills. The high cost of landfill real estate and other considerable ecological impacts created by the manufacturing of furniture should persuade people to give their belongings a longer life, but in reality, furniture is often prematurely discarded. This grounded theory study takes a multi-method approach to analyze why some types of furniture are kept longer and to theorize about new ways to design and sell furniture that lasts well past its warranty. Case studies bring new insight into designer intention, manufacturer intent, the world of auction-worthy collectables and heirlooms, why there is a booming second-hand furniture market and the growing importance of informed interior designers and architects who specify or help clients choose interior furnishings. An environmental life cycle assessment compares how the length of furniture life affects environmental impacts. A product's life could continue for generations if properly maintained. Designers and manufacturers hoping to promote longevity can apply the conclusions of this report in bringing new pieces to the market that have a much longer life span. This study finds areas of opportunity that promote user attachment, anticipate future repurposing, and provide services. This thinking envisions a paradigm for furniture that can re-invent itself over multiple generations of users, and ultimately lead to a new wave of desirable heirloom furniture.
ContributorsIngham, Sarah (Author) / White, Philip (Thesis advisor) / Wolf, Peter (Committee member) / Underhill, Michael (Committee member) / Arizona State University (Publisher)
Created2011
Description
Individuals' experiences, environment, and education greatly impact their entire being. Similarly, a designer is affected by these elements, which impacts how, what and why they design. In order for design education to generate designers who are more socially aware problem solvers, that education must introduce complex social matters and not just design skills. Traditionally designers learned through apprenticing a master. Most design education has moved away from this traditional model and has begun incorporating a well-rounded program of study, yet there are still more improvements to be made. This research proposes a new Integrated Transformational Experience Model, ITEM, for design education which will be rooted in sustainability, cultural integration, social embeddedness, and discipline collaboration. The designer will be introduced to new ideas and experiences from the immersion of current social issues where they will gain experience creating solutions to global problems enabling them to become catalysts of change. This research is based on interviews with industrial design students to gain insights, benefits and drawbacks of the current model of design education. This research will expand on the current model for design education, combining new ideas that will shed light on the future of design disciplines through the education and motivation of designers. The desired outcome of this study is to incorporate hands on learning through social issues in design classrooms, identify ways to educate future problem solvers, and inspire more research on this issue.
ContributorsWingate, Andrea (Author) / Takamura, John (Thesis advisor) / Stamm, Jill (Committee member) / Bender, Diane (Committee member) / Arizona State University (Publisher)
Created2011
Description
Interior design continues to re-define itself as a discipline that presents designers with new problems that require innovative solutions. This is particularly true in the case in office design. The transformation of the office environment from the standard bullpen configuration to today's dynamic, flexible, and open floor plans has required new design methodologies that incorporate tools and technologies that are readily available to interior designers. Today, increased use of teams in the workplace challenges interior designers to create environments that accommodate both group and individual tasks (Brill, Weidermann & BOSTI associates, 2001). Collaboration has received considerable attention as organizations focus on productivity and reducing costs to compete in a global economy (Hassanain, 2006). Designers and architects should learn to create environments that respond to dynamic, moveable, and flexible work methods. This web-based research study explores the use of pattern language as a new tool for designing collaborative work environments. In 1977, Christopher Alexander and his associates developed `Pattern language' (Alexander, Ishikawa & Silverstein, 1977) as a design formulation methodology. It consists of a series of interrelated physical elements combined to create a framework for design solutions. This pattern language tool for collaborative work environments was created based on research by Lori Anthony (2001). This study further builds upon current trends and research in collaborative work environments. The researcher conducted a pilot test by sending the web-based tool and an online questionnaire to all graduate students and faculty members in the fields of interior design and healthcare and healing environment (HHE). After testing its validity in The Design School at Arizona State University, the same tool and questionnaire was sent to the employees of one of the leading architecture and interior design firms in Phoenix, AZ. The results showed that among those design professionals surveyed, the majority believe pattern language could be a valuable design tool. The insights obtained from this study will provide designers, architects, and facility managers with a new design tool to aid in creating effective collaborative spaces in a work environment.
ContributorsSangoi, Deepika (Author) / Bender, Diane (Thesis advisor) / Brandt, Beverly (Committee member) / Heywood, William (Committee member) / Arizona State University (Publisher)
Created2011
Description
The main objective of this project was to create a framework for holistic ideation and research about the technical issues involved in creating a holistic approach. Towards that goal, we explored different components of ideation (both logical and intuitive), characterized ideation states, and found new ideation blocks with strategies used to overcome them. One of the major contributions of this research is the method by which easy traversal between different ideation methods with different components were facilitated, to support both creativity and functional quality. Another important part of the framework is the sensing of ideation states (blocks/ unfettered ideation) and investigation of matching ideation strategies most likely to facilitate progress. Some of the ideation methods embedded in the initial holistic test bed are Physical effects catalog, working principles catalog, TRIZ, Bio-TRIZ and Artifacts catalog. Repositories were created for each of those. This framework will also be used as a research tool to collect large amount of data from designers about their choice of ideation strategies used, and their effectiveness. Effective documentation of design ideation paths is also facilitated using this holistic approach. A computer tool facilitating holistic ideation was developed. Case studies were run on different designers to document their ideation states and their choice of ideation strategies to come up with a good solution to solve the same design problem.
ContributorsMohan, Manikandan (Author) / Shah, Jami J. (Thesis advisor) / Huebner, Kenneth (Committee member) / Burleson, Winslow (Committee member) / Arizona State University (Publisher)
Created2011
Description
There is a conflict in the profession of interior design over regulation through legislation. For some organizations and individuals, regulation via legislation is the next perceived step in the professionalization process which has been evolving for over 40 years and is needed to protect the health, safety and welfare (HSW) of the public. For other organizations and individuals, legislation is deemed unnecessary and an affront to the free trade market and serves only to create anti-competitive barriers resulting in the formation of a "design cartel" (Campo-Flores, 2011; Carpenter, 2007). Research exists on the professionalization of interior design and on the reasons stated for and against legislation (ASID, 2010, Anderson, Honey, Dudek, 2007, Martin, 2008). However, there is little research on understanding how the actual stake-holders view legislation. For the purpose of this research, the stake-holders are the professional interior designers themselves. The purpose of this study was to examine the current status of relevant issues to the subject of regulation in interior design and to pose the question if there is an option to legislation. If so, could third party certification be an acceptable alternative? An on-line survey was developed and posted on interior design networking sites on LinkedIn. The results of the survey suggest that interior designers are completely divided on the issue of legislation but favorably view certification. The survey has also revealed the lack of understanding of the legislative process in interior design and confusion in the role that interior design organizations play. The study has also revealed that interior designers identify the distorted view the public has of this industry as a problem. Interior designers surveyed in this study see a need to separate commercial and residential interior design. Overall, this study has concluded that interior designers would actually prefer a certification process to legislation.
ContributorsPliess, Catherine (Author) / Bender, Diane (Thesis advisor) / Crewe, Katherine (Committee member) / Kroelinger, Michael D. (Committee member) / Arizona State University (Publisher)
Created2011
Description
ABSTRACT In an attempt to advocate body-conscious design and healing work environments, this research study of holistic health in the workplace explores cognitive, social and physical well-being in four small US offices that are between 1000 and 4000 square feet and employ three to twelve employees. Holistic health, as pursued in this research, includes social health, emotional health and physical health. These three factors of holistic health have been identified and investigated in this study: biophilia: peoples' love and affiliation with other species and the natural environment; ergonomics: the relationship between the human body, movement, the immediate environment and productivity; and exercise: exertion of the body to obtain physical fitness. This research study proposes that employees and employers of these four participating workplaces desire mobility and resources in the workplace that support holistic health practices involving biophilia, ergonomics, and exercise. Literature review of holistic health and the holistic health factors of this research topic support the idea that interaction with other species can be healing, ergonomic body-conscious furniture and equipment increase productivity, limit body aches, pains and health costs; and exercise stimulates the mind and body, increasing productivity. This study has been conducted primarily with qualitative and flexible research approaches using observation, survey, interview and pedometer readings as methods for data collection. Two small corporate franchise financial institutions and two small private healthcare providers from both Arizona and Georgia participated in this study. Each office volunteered one employer and two employee participants. Of the holistic health factors considered in these four case studies, this study found that a majority of participants equally valued emotional health, social health and physical health. A majority of participants declared a preference for workplace environments with serene natural environments with outdoor spaces and interaction with other species, work environments with body-conscious furniture, equipment and workstations, as well as exercise space and equipment. As these particular workplace environments affirmed value for elements of the factors biophilia, ergonomics and exercise, all three factors are considered valueable within the workplaces of these case studies. Furthermore, factors that were said to contribute to personal productivity in participating workplaces were found as well as sacrifices that participants stated they would be willing to make in order to implement their preferred work environment(s). In addition, this study recorded and calculated average miles walked by participants in each workplace as well as existing incentives and descriptions of ideal work environments. Implications of this research study involve interior design, industrial design and fashion design that can accommodate the desires of the four participating workplaces. Major design implications involve accommodating these particular workplaces to provide personnel with opportunities for holistic health in working environments. More specific implications of office related design involve providing access to natural environments, body-conscious equipment and spaces, as well as opportunities for exercise and social interaction. These elements of the factors biophilia, ergonomics and exercise were found to be said to contribute to cognitive, social and physical health.
ContributorsMcEwan, April (Author) / White, Philip (Thesis advisor) / Shraiky, James (Committee member) / Barry, Rebecca (Committee member) / Arizona State University (Publisher)
Created2011
Description
The goal of this research was to contribute to the understanding of how the physical design of Intensive Care Unit (ICU) environments may be improved to enhance nursing communication, and in turn, the quality and safety of patient outcomes. This study was guided by two research questions: (1) What are the major characteristics of nurse communication in a hybrid ICU nurse station design? (2) What are the factors in the built environment that enhance or hinder nurse communication in a hybrid ICU nurse station design? The research design was exploratory and qualitative. Observations were conducted in two ICUs with hybrid nurse station layouts. Participant observation was used to systematically observe and document nurse communication and the physical attributes of the ICU nurse work environment that affect communication. Literature, observations, and information regarding staffing and design about the selected ICUs were analyzed for the generation of concepts and the exploration of significant themes. Results show that nurse interactions with other staff members varied within the different zones of the ICU pod. A biaxial map illustrates four key types of core nurse communication interactions: At ease, On guard, In motion, and On the edge. The quadrants representing barriers to nurse communication are On guard and On the edge, and included interactions with other staff members in the pod. The quadrants representing facilitators to nurse communication are At ease and In motion. The hybrid nurse station layout supported nurse-nurse communication, but not communication interactions with other staff members present on the pod. The results provide a broad understanding of how nurse communication is affected by the environment in which nurses work, and allows for the emergence of design opportunities to enhance nurse communication.
ContributorsNewcomb, Emily Michelle Darling (Author) / Lamb, Gerri (Thesis advisor) / Stein, Morris (Thesis advisor) / Wolf, Peter (Committee member) / Arizona State University (Publisher)
Created2011
Description
Non-native saltcedar (Tamarix spp.) has invaded many riparian communities and is the third most abundant tree in Southwestern riparian areas. I evaluated lizard populations and microhabitat selection during 2009 and 2010 along the Virgin River in Nevada and Arizona to determine the impact of saltcedar. Along the riparian corridor, I observed common side-blotched lizards (Uta stansburiana) within two vegetation types: monotypic non-native saltcedar stands or mixed stands of cottonwood (Populus fremontii), willow (Salix spp.), mesquite (Prosopis spp.) and saltcedar. I predicted that population parameters such as body condition, adult to hatchling ratio, abundance, and persistence would vary among vegetation types. Also, I predicted the presence of saltcedar influences how lizards utilize available habitat. Lizard population parameters were obtained from a mark-recapture study in which I captured 233 individual lizards. I examined habitat selection and habitat availability using visual encounter surveys (VES) for lizards and recorded 11 microhabitat variables where 16 lizards were found. I found no significant difference in population parameters between mixed and non-native saltcedar communities. However, population parameters were negatively correlated with canopy cover. I found that lizards selected habitat with low understory and canopy cover regardless of vegetation type. My results indicate that lizards utilize similar structural characteristics in both mixed and non-native vegetation. Understanding impacts of saltcedar on native fauna is important for managers who are tasked with control and management of this non-native species.
ContributorsNielsen, Danny (Author) / Bateman, Heather L. (Thesis advisor) / Miller, William H. (Committee member) / Sullivan, Brian K. (Committee member) / Arizona State University (Publisher)
Created2011