Matching Items (6)
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In December 2011, the Stillbirth Collaborative Research Network, or SCRN, published the article “Causes of Death Among Stillbirths” in The Journal of the American Medical Association. The authors of the article investigate the causes of stillbirth and possible reasons for the racial, ethnic, and geographic disparities in stillbirth rates. According

In December 2011, the Stillbirth Collaborative Research Network, or SCRN, published the article “Causes of Death Among Stillbirths” in The Journal of the American Medical Association. The authors of the article investigate the causes of stillbirth and possible reasons for the racial, ethnic, and geographic disparities in stillbirth rates. According to the Centers for Disease Control and Prevention, or CDC, stillbirth is the death of a fetus at twenty or more weeks during pregnancy. “Causes of Death Among Stillbirths” explores the common causes of stillbirth in different racial and ethnic groups, and provides a framework for future research into medical interventions to help reduce racial and ethnic stillbirth disparity.

Created2021-06-10
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In April 1994, Elizabeth Raymond, Sven Cnattingius, and John Kiely published “Effects of Maternal Age, Parity, and Smoking on the Risk of Stillbirth” in the British Journal of Obstetrics and Gynecology, now known as BJOG: An International Journal of Obstetrics and Gynecology. The article examines how advanced maternal age, defined

In April 1994, Elizabeth Raymond, Sven Cnattingius, and John Kiely published “Effects of Maternal Age, Parity, and Smoking on the Risk of Stillbirth” in the British Journal of Obstetrics and Gynecology, now known as BJOG: An International Journal of Obstetrics and Gynecology. The article examines how advanced maternal age, defined as delivery at thirty-five years old or older, cigarette smoking, and nulliparity, or the state of never having given birth, can negatively impact pregnancy. At the time of publication, according to Raymond and colleagues, stillbirths comprised over half of all perinatal, or close to birth, deaths and more than one-third of total fetal and infant deaths in Europe and North America. In the article, Raymond and her coauthors demonstrate how certain risk factors may increase the risk of stillbirth at different stages of pregnancy, which helped set a foundation for future research in interventions to prevent stillbirth.

Created2021-06-18
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Kurt Benirschke studied cells, placentas, and endangered species in Germany and the US during the twentieth century. Benirschke was professor at the University of California in San Diego, California, and a director of the research department at the San Diego Zoo in San Diego, California. He also helped form the

Kurt Benirschke studied cells, placentas, and endangered species in Germany and the US during the twentieth century. Benirschke was professor at the University of California in San Diego, California, and a director of the research department at the San Diego Zoo in San Diego, California. He also helped form the research department of the San Diego Zoo and its sister organization, the Center for Reproduction of Endangered Species. Benirschke contributed to the field of embryology through his work on human and animal reproduction, including work on human placentas and birth defects, through work on the structure of chromosomes, and through work on the reproduction and conservation of endangered species.

Created2016-04-26
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In 2004, a team of researchers at Tufts-New England
Medical Center in Boston, Massachusetts, investigated the fetal
cells that remained in the maternal blood stream after pregnancy.
The results were published in Transfer of Fetal Cells with
Multilineage Potential to Maternal Tissue. The team working on

In 2004, a team of researchers at Tufts-New England
Medical Center in Boston, Massachusetts, investigated the fetal
cells that remained in the maternal blood stream after pregnancy.
The results were published in Transfer of Fetal Cells with
Multilineage Potential to Maternal Tissue. The team working on that
research included Kiarash Khosrotehrani, Kirby L. Johnson, Dong
Hyun Cha, Robert N. Salomon, and Diana W. Bianchi. The researchers
reported that the fetal cells passed to a pregnant woman during
pregnancy could develop into multiple cell types in her organs. They
studied these differentiated fetal cells in a cohort of women
fighting different diseases. The researchers found that the fetal
cells in the women differentiated into different cell types under
the influence of maternal tissues, and that those differentiated
cells concentrated in the tissue surrounding diseased tissues.
According to the team, this response could be a therapeutic response
to the disease in the once pregnant woman. The research indicated the long
lasting effects of pregnancy in a woman's body.

Created2014-11-14
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William Hunter’s Anatomia Uteri Humani Gravidi Tabulis Illustrata (The Anatomy of the Human Gravid Uterus Exhibited in Figures), hereafter called The Human Gravid Uterus, is an anatomical atlas depicting the pregnant form through both engravings and descriptions. William Hunter, an anatomist working in England during the eighteenth century, compiled the

William Hunter’s Anatomia Uteri Humani Gravidi Tabulis Illustrata (The Anatomy of the Human Gravid Uterus Exhibited in Figures), hereafter called The Human Gravid Uterus, is an anatomical atlas depicting the pregnant form through both engravings and descriptions. William Hunter, an anatomist working in England during the eighteenth century, compiled the work based on observations from his dissections of pregnant women. The collection of thirty-four copper plate illustrations details the anatomy of the pregnant human womb (gravid uterus), and includes depictions of unborn fetuses at various stages of development. Hunter compiled The Human Gravid Uterus to provide an objective anatomical depiction of pregnancy and development at a time when midwifery and obstetrics were becoming prominent fields of medical practice in England.

Created2017-04-13
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The human placenta is comprised of trophoblast subtypes – cytotrophoblasts, syncytiotrophoblasts (ST), and extravillous trophoblasts (EVT) – that are crucial for successful pregnancies. Understanding trophoblast functions is essential to treat pregnancy complications and investigate maternal-fetal immune tolerance. Trophoblasts secrete factors to instruct tolerance; however, the distinct trophoblast subtypes’ role in

The human placenta is comprised of trophoblast subtypes – cytotrophoblasts, syncytiotrophoblasts (ST), and extravillous trophoblasts (EVT) – that are crucial for successful pregnancies. Understanding trophoblast functions is essential to treat pregnancy complications and investigate maternal-fetal immune tolerance. Trophoblasts secrete factors to instruct tolerance; however, the distinct trophoblast subtypes’ role in fetal tissue tolerance remain insufficiently understood. Inadequate models to study the human placenta in vitro limit the current understanding of human placental behavior and development. Synthetic hydrogel systems such as poly(ethylene) glycol (PEG)-maleimide offer a highly defined, tunable 3D environment to study trophoblast subtypes, which may overcome experimental variability in naturally derived hydrogels like Matrigel due to batch-to-batch variability. Here, a PEG hydrogel system with tunable degradability and placenta-derived extracellular matrix ligands is employed to evaluate the capacity of the hydrogel library to support the function and phenotypic protein expression of three trophoblast-like cell lines, assess the differentiation of trophoblast stem cells (TSC), and explore the effects of trophoblast supernatants on the modulation of protein expression and secretion by immune cell subsets present at the maternal-fetal interface. Degradable synthetic hydrogels support the greatest degree of trophoblast-like spheroid proliferation and function relative to standard Matrigel controls and culture conditions modulate trophoblast-like and TSC functional subtype as measured by proteomics analysis and functional secretion assays. PEG hydrogels support TSC viability and function comparable to Matrigel; however, ST-differentiated cells prefer PEG environments, while EVT-differentiated cells favor Matrigel, as assessed through phenotypic protein expression and secretion. These data highlight the influence of trophoblast culture condition and subtype on immune cell protein expression and inflammatory cytokine secretion in response to trophoblast supernatants. This model advances the understanding of in vitro placental modeling, which can provide insights on pregnancy-related complications and maternal-fetal immunotolerance.
ContributorsSlaby, Emily M (Author) / Weaver, Jessica D. (Thesis advisor) / Acharya, Abhinav P. (Committee member) / Holloway, Julianne L. (Committee member) / Stabenfeldt, Sarah E. (Committee member) / Wang, Kuei-Chun (Committee member) / Arizona State University (Publisher)
Created2024