In “The Social and Psychological Impact of Endometriosis on Women’s Lives: A Critical Narrative Review,” hereafter “Social and Psychological Impact of Endometriosis,” authors Lorraine Culley, Caroline Law, Nicky Hudson, Elaine Denny, Helene Mitchell, Miriam Baumgarten, and Nicholas Raine-Fenning review the extent at which endometriosis results in a negative quality of life for affected women. Endometriosis is a condition characterized by the growth of cells similar to that of the endometrium, or the tissue that lines the uterus, outside of the uterus, and can cause heavy menstrual periods, pain, and infertility. Such symptoms can impact how women balance romantic or sexual relationships, due to the fact that endometriosis can cause chronic pelvic pain and pain during sexual intercourse. The authors found that women living with endometriosis are more likely to experience depression or anxiety, and conclude that the lack of both overall academic research and factual information given to women at diagnosis results in negative effects on their psychological wellbeing.

Intrauterine devices, or IUDs, are long-lasting forms of birth control that have effectiveness comparable to sterilization, while they can be removed at any time. However, the insertion process can be very painful, especially for individuals who have never given vaginal birth. The most common form of pain management for this procedure is having the patient take an ibuprofen an hour or so before the procedure, but this only helps with cramping afterwards, not the acute pain caused by insertion. Pain, and anxiety and fear regarding potential pain, serve as a barrier between users and this highly effective form of birth control. This report uses COMSOL to model lidocaine diffusion from 4% topical hydrogel into the cervix (the main site of acute pain during IUD insertion) over 180 minutes. The cervix was modeled axisymmetrically, using average experimental values for cervix size. Concentration at four specific probe points were measured over time and compared at different concentrations. A sensitivity analysis was performed by adjusting the diffusion coefficient of the epithelial layer. This model was developed to serve as a predictor for future drug applications across the cervix, to determine in advance whether a novel formulation of drug would be effective to significantly reduce pain. This model may be refined further with experimental values for the constants, and with further testing of different lidocaine concentrations.

Patients receiving total knee arthroplasty surgery received either IV Meloxicam or Oral Celecoxib based on the hospital where they were treated. Otherwise, the operation and post-surgical pain protocol were kept as identical as possible. Surveys were administered at 24, 48, and 72 hours after surgery where patients reported their current pain level, and cumulative number or narcotic pain pills taken since surgery. Results showed a trend at each measured time interval for those receiving IV Meloxicam to report lower pain scores and less narcotic usage on average. Only the pain score difference reported at 72 hours was statistically significant. Due to limited number of study participants, further testing would be needed to determine if other observed differences would become statistically significant.