Description
Rupture of intracranial aneurysms causes a subarachnoid hemorrhage, which is often lethal health event. A minimally invasive method of solving this problem may involve a material, which can be administered as a liquid and then becomes a strong solid within minutes preventing flow of blood in the aneurysm. Here we report on the development of temperature responsive copolymers, which are deliverable through a microcatheter at body temperature and then rapidly cure to form a highly elastic hydrogel. To our knowledge, this is the first physical-and chemical-crosslinked hydrogel capable of rapid crosslinking at temperatures above the gel transition temperature. The polymer system, poly(N-isopropylacrylamide-co-cysteamine-co-Jeffamine® M-1000 acrylamide) and poly(ethylene glycol) diacrylate, was evaluated in wide-neck aneurysm flow models to evaluate the stability of the hydrogels. Investigation of this polymer system indicates that the Jeffamine® M-1000 causes the gels to retain water, resulting in gels that are initially weak and viscous, but become stronger and more elastic after chemical crosslinking.
Details
Title
- Easily deliverable and elastic thermosensitive physical-chemical gelling hydrogels for embolization
Contributors
- Lee, Elizabeth Jean (Author)
- Vernon, Brent (Thesis director)
- Brennecka, Celeste (Committee member)
- Overstreet, Derek (Committee member)
- Barrett, The Honors College (Contributor)
- School of Mathematical and Statistical Sciences (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2013-05
Resource Type
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