In the past decade, technological breakthroughs have facilitated structure determination of so many difficult-to-study membrane protein targets. In this thesis research, three techniques were investigated to enable the structural determination of such challenging targets, polychromatic pink-beam serial crystallography with high-viscous sample, lipidic cubic phase (LCP)-based microcrystal electron diffraction (MicroED), and single-particle cryogenic electron microscopy targeting (cryoEM).
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- Partial requirement for: Ph.D., Arizona State University, 2019Note typethesis
- Includes bibliographical referencesNote typebibliography
- Field of study: Biochemistry