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Antibodies are naturally occurring proteins that protect a host during infection through direct neutralization and/or recruitment of the innate immune system. Unfortunately, in some infections, antibodies present unique hurdles that

Antibodies are naturally occurring proteins that protect a host during infection through direct neutralization and/or recruitment of the innate immune system. Unfortunately, in some infections, antibodies present unique hurdles that must be overcome for a safer and more efficacious antibody-based therapeutic (e.g., antibody dependent viral enhancement (ADE) and inflammatory pathology). This dissertation describes the utilization of plant expression systems to produce N-glycan specific antibody-based therapeutics for Dengue Virus (DENV) and Chikungunya Virus (CHIKV).

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Date Created
  • 2019
Resource Type
  • Text
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    Note
    • Partial requirement for: Ph.D., Arizona State University, 2019
      Note type
      thesis
    • Includes bibliographical references throughout (comprehensive references pages 164- 194)
      Note type
      bibliography
    • Field of study: Molecular and Cellular Biology

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    by Jonathan Hurtado

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