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Nicotine self-administration is associated with decreased expression of the glial glutamate transporter 1 (GLT-1) and the cystine-glutamate exchange protein xCT in the nucleus accumbens core (NAcore). N-acetylcysteine (NAC), which is

Nicotine self-administration is associated with decreased expression of the glial glutamate transporter 1 (GLT-1) and the cystine-glutamate exchange protein xCT in the nucleus accumbens core (NAcore). N-acetylcysteine (NAC), which is an antioxidant, anti-inflammatory, and glutamatergic agent, restores these proteins associated with increased relapse vulnerability. However, the specific molecular mechanisms driving NAC inhibitory effects on cue-induced nicotine reinstatement are unknown.

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Date Created
  • 2019
Resource Type
  • Text
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    Note
    • Partial requirement for: M.A., Arizona State University, 2019
      Note type
      thesis
    • Includes bibliographical references (pages 31-43)
      Note type
      bibliography
    • Field of study: Psychology

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    by Mark Douglas Namba

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