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Obesity impairs skeletal muscle maintenance and regeneration, a condition that can progressively lead to muscle loss, but the mechanisms behind it are unknown. Muscle is primarily composed of multinucleated cells

Obesity impairs skeletal muscle maintenance and regeneration, a condition that can progressively lead to muscle loss, but the mechanisms behind it are unknown. Muscle is primarily composed of multinucleated cells called myotubes which are derived by the fusion of mononucleated myocytes. A key mediator in this process is the cellular fusion protein syncytin-1. This led to the hypothesis that syncytin-1 could be decreased in the muscle of obese/insulin resistant individuals.

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    Date Created
    • 2017
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  • Text
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    • Partial requirement for: M.S., Arizona State University, 2017
      Note type
      thesis
    • Includes bibliographical references (pages 43-47)
      Note type
      bibliography
    • Field of study: Biology

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    by Jayachandran Ravichandran

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