Full metadata
Title
Individual differences in subjective response to alcohol: pharmacokinetic and pharmacodynamic factors
Description
Variability in subjective response to alcohol has been shown to predict drinking behavior as well as the development of alcohol use disorders. The current study examined the extent to which individual differences in alcohol pharmacokinetics impact subjective response and drinking behavior during a single session alcohol administration paradigm. Participants (N = 98) completed measures of subjective response at two time points following alcohol consumption. Pharmacokinetic properties (rate of absorption and metabolism) were inferred using multiple BAC readings to calculate the area under the curve during the ascending limb for absorption and descending limb for metabolism. Following the completion of the subjective response measures, an ad-libitum taste rating task was implemented in which participants were permitted to consume additional alcoholic beverages. The amount consumed during the taste rating task served as the primary outcome variable. Results of the study indicated that participants who metabolized alcohol more quickly maintained a greater level of subjective stimulation as blood alcohol levels declined and reported greater reductions in subjective sedation. Although metabolism did not have a direct influence on within session alcohol consumption, a faster metabolism did relate to increased ad-libitum consumption indirectly through greater acute tolerance to sedative effects and greater maintenance of stimulant effects. Rate of absorption did not significantly predict subjective response or within session drinking. The results of the study add clarity to theories of subjective response to alcohol, and suggest that those at highest risk for alcohol problems experience a more rapid reduction in sedation following alcohol consumption while simultaneously experiencing heightened levels of stimulation. Variability in pharmacokinetics, namely how quickly one metabolizes alcohol, may be an identifiable biomarker of subjective response and may be used to infer risk for alcohol problems.
Date Created
2014
Contributors
- Boyd, Stephen (Author)
- Corbin, William R. (Thesis advisor)
- Chassin, Laurie (Committee member)
- MacKinnon, David (Committee member)
- Olive, Michael Foster (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
ix, 136 pages : illustrations (some color)
Language
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.I.34937
Statement of Responsibility
by Stephen Boyd
Description Source
Viewed on December 10, 2015
Level of coding
full
Note
Partial requirement for: Ph. D., Arizona State University, 2014
Note type
thesis
Includes bibliographical references (pages 74-84)
Note type
bibliography
Field of study: Psychology
System Created
- 2015-08-17 11:57:55
System Modified
- 2021-08-30 01:26:56
- 2 years 8 months ago
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