In vitro selection technologies allow for the identification of novel biomolecules endowed with desired functions. Successful selection methodologies share the same fundamental requirements. First, they must establish a strong link between the enzymatic function being selected (phenotype) and the genetic information responsible for the function (genotype). Second, they must enable partitioning of active from inactive variants, often capturing only a small number of positive hits from a large population of variants.
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- Partial requirement for: Ph.D., Arizona State University, 2015Note typethesis
- Includes bibliographical referencesNote typebibliography
- Field of study: Biological design