Full metadata
Title
Surface modification of polydimethyl siloxane using polyethylene oxide copolymers
Description
Polydimethyl siloxane is a commonly used fabrication material for microfluidic devices. However, its hydrophobic nature and protein adsorption on the surface restricts its use for microfluidic applications. Also, it is critical to control the electroosmotic flow for electrophoretic and dielectrophoretic manipulations. Therefore, surface modification of PDMS is essential to make it well suited for bioanalytical applications. In this project, the role of polyethylene oxide copolymers F108 and PLL-PEG has been investigated to modify the surface properties of PDMS using physisorption method. Measuring electroosmotic flow and adsorption studies tested the quality and the long-term stability of the modified PDMS surface. Static and dynamic coating strategies were used to modify the PDMS surface. In static coating, the PDMS surface was incubated with the coating agent prior to the measurements. For dynamic coating, the coating agent was always present in the solution throughout the experiment. F108 and PLL-PEG were equally effective to prevent the protein adsorption under both strategies. However, dynamic coating was more time saving. Furthermore, effective reduction of EOF was observed with F108 coating agent under dynamic conditions and with PLL-PEG coating agent under static conditions. Moreover, PLL-PEG dynamic coatings exhibited reversal of EOF. These important findings could be used to manipulate EOF and suggest optimal coating agent and strategies for PDMS surface treatment by the physisorption method.
Date Created
2012
Contributors
- Manchanda, Shikha (Author)
- Ros, Alexandra (Thesis advisor)
- Hayes, Mark (Committee member)
- Liu, Yan (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
vii, 38 p. : ill. (some col.)
Language
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.I.14948
Statement of Responsibility
by Shikha Manchanda
Description Source
Retrieved on April 29, 2013
Level of coding
full
Note
Partial requirement for: M.S., Arizona State University, 2012
Note type
thesis
Includes bibliographical references (p. 35-38)
Note type
bibliography
Field of study: Chemistry
System Created
- 2012-08-24 06:27:02
System Modified
- 2021-08-30 01:46:28
- 2 years 8 months ago
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