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Description

Prevalence of esophageal adenocarcinoma (EAC) has increased six-fold in the United States over the past four decades due to increases in associated risk factors, namely obesity and gastroesophageal reflux disease.

Prevalence of esophageal adenocarcinoma (EAC) has increased six-fold in the United States over the past four decades due to increases in associated risk factors, namely obesity and gastroesophageal reflux disease. The most common genomic driver of EAC, tumor protein 53 (TP53) mutation, has previously been therapeutically intractable, affirming the unmet clinical need to deploy novel therapeutic strategies targeting this genomic driver in this tumor type.

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Date Created
  • 2017-05
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  • Text
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