Ghrelin is an acylated peptide hormone with far reaching affects within the human body. Consisting of both central and peripheral effects, ghrelin has been the topic of research since its discovery in 1999. These effects include energy maintenance, cardiovascular health, growth hormone mediation, glucose homeostasis, muscle growth and atrophy, and bone metabolism, all of which work in concert with other well-known physiological mechanisms. With the goal to reproduce a similar study done in females in males, this study hypothesized that ghrelin would present an inverse relationship with a young healthy male population's resting metabolic rates. The study consisted of taking resting metabolic rate measurements, dual-energy X-ray absorptiometry, blood ghrelin testing, and statistical analysis of the data. The hypothesis was shown to be incorrect as the data showed a positive correlation, albeit, with very low statistical significance. Despite the data, past research has shown ghrelin plays a major role in fat gain, fat loss, and energy expenditure. Obesity is plaguing the world and becoming a major pubic health concern. It is necessary to explore causality and casual relationships in order to better understand and combat obesity. Therefore, further research is warranted into ghrelin and energy expenditure as a biomarker or novel treatment for obesity.
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