Matching Items (26)
Description
Scientific researchers have studied microorganisms since the emergence of the single lens microscope in the 17th century. Since then, researchers designed and published many thousands of images to record and share their observations, including hand-drawn diagrams, photomicrographs, and photographs. Images shaped how researchers conceived of microorganisms, their concepts of microorganisms shaped their images, and their images and concepts were shaped by the contexts in which they were working. Over time, the interplay of images and concepts in various research contexts participated in the development of new concepts related to microorganisms, like the “biofilm” concept, or the idea that bacteria exist in nature as complex aggregates attached to surfaces via extracellular polymeric matrices. Many histories of microbiology locate the origin of the biofilm concept in the 1970s, but that date obscures the rich history of research about attached microbial aggregates that occurred throughout the history of microbiology. I discovered how the interplay of images and concepts related to bacteria participated in the development of the biofilm concept by documenting when and why researchers used different visual features to represent changing concepts related to microorganisms. I specifically examined how and why scientists represented evolving concepts related to bacteria during the 17th century (Chapter 1), from the late 17th century to the early 20th century (Chapter 2), and during the first seventy-four years of the 20th century (Chapter 3). I discovered the biofilm concept developed in at least three unique research contexts during the 20th century, and how images reflected and shaped the concept’s development in each case. The narrative and collection of images generated from this work serve as a visual history of the development of scientists’ ideas about the nature of bacteria over 300 years.
ContributorsGuerrero, Anna Clemencia (Author) / Maienschein, Jane (Thesis advisor) / Laubichler, Manfred (Committee member) / Sterner, Beckett (Committee member) / Matlin, Karl (Committee member) / Arizona State University (Publisher)
Created2023
Description
Computational tools in the digital humanities often either work on the macro-scale, enabling researchers to analyze huge amounts of data, or on the micro-scale, supporting scholars in the interpretation and analysis of individual documents. The proposed research system that was developed in the context of this dissertation ("Quadriga System") works to bridge these two extremes by offering tools to support close reading and interpretation of texts, while at the same time providing a means for collaboration and data collection that could lead to analyses based on big datasets. In the field of history of science, researchers usually use unstructured data such as texts or images. To computationally analyze such data, it first has to be transformed into a machine-understandable format. The Quadriga System is based on the idea to represent texts as graphs of contextualized triples (or quadruples). Those graphs (or networks) can then be mathematically analyzed and visualized. This dissertation describes two projects that use the Quadriga System for the analysis and exploration of texts and the creation of social networks. Furthermore, a model for digital humanities education is proposed that brings together students from the humanities and computer science in order to develop user-oriented, innovative tools, methods, and infrastructures.
ContributorsDamerow, Julia (Author) / Laubichler, Manfred (Thesis advisor) / Maienschein, Jane (Thesis advisor) / Creath, Richard (Committee member) / Ellison, Karin (Committee member) / Hooper, Wallace (Committee member) / Renn, Jürgen (Committee member) / Arizona State University (Publisher)
Created2014
Description
Abortion is a controversial topic internationally. Most current debates about abortion concern when, if at all, it should be legal. However, researchers have shown many times that after an abortion ban, maternal and infant mortalities rise significantly, as women who seek out abortions do so regardless of abortion legality. So, is it possible to reduce abortions in a population without delegalizing abortion and, if so, how? Why do some countries have higher abortion rates than others in the presence of the same law?This dissertation answers both questions. First, I present historical evidence in the first comprehensive comparative analysis of all 15 post-Soviet countries, which have very similar abortion laws originating from the Union of Soviet Socialist Republics (USSR). Second, I use those findings to build the first agent-based model (ABM) of unintended pregnancies in a hypothetical artificial population.
USSR was the only country in the world to complete its demographic transition through abortion instead of modern contraception, and the Soviet government passed the first law in the world to allow abortion upon request in 1920. After the USSR dissolution in 1991, post-Soviet countries maintained very similar abortion laws, but had very different abortion rates for most years. Analysis of fertility data from post-Soviet countries shows that the prevalence of some specific contraceptive methods, namely the rhythm method (r = 0.82), oral pill (r = 0.56), and male condom (r = 0.51) are most strongly correlated with high abortion rates, and that sex education is a factor that reduces the rates in otherwise similar countries (p = 0.02).
The ABM shows that even basic sex education results in fewer abortions than no sex education or abstinence-based sex education (p < 0.01). In scenarios without sex education, basic quality of post-abortion contraceptive counseling (PACC) is better than no PACC or low-quality PACC at reducing abortions (p < 0.01). Still, the higher the quality of sex education or PACC, the fewer abortions in the artificial population. The ABM is adaptive and policy makers can use it as a decision-support tool to make evidence-based policy decisions regarding abortion, and, potentially, other sociobiological phenomena with some adjustments to the code.
ContributorsZiganshina Lienhard, Dina A. (Author) / Maienschein, Jane (Thesis advisor) / Gaughan, Monica (Thesis advisor) / Laubichler, Manfred (Committee member) / Ellison, Karin (Committee member) / Arizona State University (Publisher)
Created2023
Description
In 1830, a dispute erupted in the halls of lÕAcad mie des Sciences in Paris between the two most prominent anatomists of the nineteenth century. Georges Cuvier and tienne Geoffroy Saint-Hilaire, once friends and colleagues at the Paris Museum, became arch rivals after this historical episode. Like many important disputes in the history of science, this debate echoes several points of contrasts between the two thinkers. The two French Ânaturalists not only disagreed about what sorts of comparisons between vertebrates were acceptable, but also about which principles ought to underlie a rational system of animal taxonomy and guide the study of animal anatomy. Digging deeper into their differences, their particular disagreements over specific issues within zoology and anatomy culminated in the articulation of two competing and divergent philosophical views on the aims and methods of the life sciences. The emergence of these two distinct positions has had a lasting impact in the development of evolutionary and developmental biology. This essay will provide an overview of the conceptual themes of the debate, its implications for the development of the life sciences, and its role in the history of embryology and developmental biology.
ContributorsRacine, Valerie (Author) / Maienschein, Jane (Editor) / Laubichler, Manfred (Editor) / Arizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia. (Publisher) / Arizona Board of Regents (Publisher)
Created2013-10-07
Description
Transgenic experiments in Drosophila have proven to be a useful tool aiding in the
determination of mammalian protein function. A CNS specific protein, dCORL is a
member of the Sno/Ski family. Sno acts as a switch between Dpp/dActivin signaling.
dCORL is involved in Dpp and dActivin signaling, but the two homologous mCORL
protein functions are unknown. Conducting transgenic experiments in the adult wings,
and third instar larval brains using mCORL1, mCORL2 and dCORL are used to provide
insight into the function of these proteins. These experiments show mCORL1 has a
different function from mCORL2 and dCORL when expressed in Drosophila. mCORL2
and dCORL have functional similarities that are likely conserved. Six amino acid
substitutions between mCORL1 and mCORL2/dCORL may be the reason for the
functional difference. The evolutionary implications of this research suggest the
conservation of a switch between Dpp/dActivin signaling that predates the divergence of
arthropods and vertebrates.
determination of mammalian protein function. A CNS specific protein, dCORL is a
member of the Sno/Ski family. Sno acts as a switch between Dpp/dActivin signaling.
dCORL is involved in Dpp and dActivin signaling, but the two homologous mCORL
protein functions are unknown. Conducting transgenic experiments in the adult wings,
and third instar larval brains using mCORL1, mCORL2 and dCORL are used to provide
insight into the function of these proteins. These experiments show mCORL1 has a
different function from mCORL2 and dCORL when expressed in Drosophila. mCORL2
and dCORL have functional similarities that are likely conserved. Six amino acid
substitutions between mCORL1 and mCORL2/dCORL may be the reason for the
functional difference. The evolutionary implications of this research suggest the
conservation of a switch between Dpp/dActivin signaling that predates the divergence of
arthropods and vertebrates.
ContributorsStinchfield, Michael J (Author) / Newfeld, Stuart J (Thesis advisor) / Capco, David (Committee member) / Laubichler, Manfred (Committee member) / Arizona State University (Publisher)
Created2019
Description
Getting clear about what behavioral scientists mean when they invoke content presupposing concepts, like information, is necessary for understanding how humanity’s own behavioral capacities do or do not relate to those of non-human animals. Yet, producing a general naturalistic definition for representational content has proven notoriously difficult. Some have argued that Claude Shannon’s formal, mathematically defined notion of information is the proper starting point for building a biological theory of content. Others have sought to define content presupposing concepts in terms of the historical selection processes that drive evolution. However, neither approach has produced definitions that capture the way successful researchers in the behavioral sciences use content-presupposing concepts. In this dissertation, I examine an ethological tradition of insect navigation research that has consistently ascribed content to insects. To clarify the meaning of such ascriptions, I analyze the practices scientists use to justify new attributions of content and the way new attributions of content guide scientists’ future research activities. In chapter 1, I examine a series of insect navigation experiments performed in 2006–2007 that led to a novel ascription of content. I argue that researchers ascribe content to insects’ navigation behaviors when those behaviors reliably accomplish a difficult goal-directed function. I also argue that ascriptions of content help researchers achieve their epistemic aims by guiding hypothesis formation and aiding comparative theorizing.
In chapter 2, I trace the history of the experimental strategy analyzed above
back to the work of Karl von Frisch in the early 20th century. I argue that von Frisch has a complicated and understudied relationship to the discipline of ethology. I support that argument by highlighting features of von Frisch’s research that both comported with and differed from the program of classical ethology.
In chapter 3, I examine the cognitive map debate in insects. I argue that the debate stems from competing research groups’ endorsement of different norms for justifying claims about the dynamics of representational contents. I then situate these different norms historically to show how the cognitive map debate is a continuation of longstanding divisions within the history of animal behavior research.
ContributorsDhein, Kelle (Author) / Sterner, Beckett (Thesis advisor) / Maienschein, Jane (Committee member) / Allen, Colin (Committee member) / Pratt, Stephen (Committee member) / Laubichler, Manfred (Committee member) / Arizona State University (Publisher)
Created2021