determination of mammalian protein function. A CNS specific protein, dCORL is a
member of the Sno/Ski family. Sno acts as a switch between Dpp/dActivin signaling.
dCORL is involved in Dpp and dActivin signaling, but the two homologous mCORL
protein functions are unknown. Conducting transgenic experiments in the adult wings,
and third instar larval brains using mCORL1, mCORL2 and dCORL are used to provide
insight into the function of these proteins. These experiments show mCORL1 has a
different function from mCORL2 and dCORL when expressed in Drosophila. mCORL2
and dCORL have functional similarities that are likely conserved. Six amino acid
substitutions between mCORL1 and mCORL2/dCORL may be the reason for the
functional difference. The evolutionary implications of this research suggest the
conservation of a switch between Dpp/dActivin signaling that predates the divergence of
arthropods and vertebrates.
The purpose of this Honors Thesis was to first, understand the implications of social isolation and loneliness on an individuals’ physical and mental health and second, uncover successful strategies that individuals used to overcome social isolation and loneliness. This thesis used two primary data sets to draw conclusions about individuals’ subjective feelings of loneliness and isolation and to further understand what strategies were used to overcome these feelings. The results from this thesis demonstrated that individuals who successfully avoided feelings of social isolation and loneliness during the COVID-19 pandemic took up new activities, used strategies to facilitate communication, participated in community engagement, completed acts of service, practiced mindfulness and reflection, and made new connections.