Skin cancer diagnoses and deaths continue to increase every year. With basal cell carcinoma (BCC) being the most common type of skin cancer diagnoses, establishing protective measurements against it are important. Surprisingly, sunscreen may not be as effective at protecting against basal cell carcinoma as it is for another non-melanoma type of skin cancer: squamous cell carcinoma. This paper aims to identify some differences between the two non-melanoma type cancers to find probable reasons sunscreen may be more effective at protecting against one over the other, as well as to find new solutions to protect against basal cell carcinoma. The results conclude that basal cell carcinoma does have UV-induced pathogenesis, in which case sunscreen is protective; however, it also revealed the need for ingredient studies and more sunscreen efficacy studies to determine other BCC pathogenesis pathways. Lastly, aided by dermatologist interviews, current interventions were established in order to provide greater protection against skin cancer. These include reforming the way commercials portray sunscreen to better educate the public about proper application and re-application, genetic testing for high-risk BCC markers, and an emphasis on sun education to the mothers of children.
This meta-study analyzes the shift in research literature that focuses on the various shared causes of type 2 diabetes and Alzheimer’s disease from the years 2000 to 2022. Examining literature trends over the past two decades can offer valuable insight into the evolving emphasis on various topics. Altogether, a total of 154 publications were collected from the Pubmed and ResearchGate databases using a non-biased protocol and methodology. Each paper was then categorized by the topics it discussed. Visual representation of the data such as bar graphs and tables were created to comprehend the trends presented in the group of papers. The collection of publications were then differentiated into years of early (prior to 2005 or 2010) and late (after 2006 or 2011) periods to perform a statistical analysis of the patterns in the timeline. The increase in publications discussing Alzheimer’s disease, amyloid beta deposition, gut microbiota, mitochondrial dysfunction, type 2 diabetes, and tau hyperphosphorylation from the early to the late period were statistically significant. This means that the increase was not due to random chance, but rather supported by evidence. This can be attributed to researchers and physicians discovering more evidence that establishes a link between specific factors, type 2 diabetes, and Alzheimer’s disease. This reflects a genuine acknowledgment of the importance of understanding and addressing the relationship between these two pathologies. Research in the trends of literature can provide information in which areas of research are the most studied or understudied. Based on these findings, the identification of areas with limited knowledge and potential research directions can be inferred, ultimately leading to the enhancement of preventive measures and therapeutic approaches for these conditions.