Matching Items (13)
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Description
Passive radar can be used to reduce the demand for radio frequency spectrum bandwidth. This paper will explain how a MATLAB simulation tool was developed to analyze the feasibility of using passive radar with digitally modulated communication signals. The first stage of the simulation creates a binary phase-shift keying (BPSK)

Passive radar can be used to reduce the demand for radio frequency spectrum bandwidth. This paper will explain how a MATLAB simulation tool was developed to analyze the feasibility of using passive radar with digitally modulated communication signals. The first stage of the simulation creates a binary phase-shift keying (BPSK) signal, quadrature phase-shift keying (QPSK) signal, or digital terrestrial television (DTTV) signal. A scenario is then created using user defined parameters that simulates reception of the original signal on two different channels, a reference channel and a surveillance channel. The signal on the surveillance channel is delayed and Doppler shifted according to a point target scattering profile. An ambiguity function detector is implemented to identify the time delays and Doppler shifts associated with reflections off of the targets created. The results of an example are included in this report to demonstrate the simulation capabilities.
ContributorsScarborough, Gillian Donnelly (Author) / Cochran, Douglas (Thesis director) / Berisha, Visar (Committee member) / Wang, Chao (Committee member) / Barrett, The Honors College (Contributor) / Electrical Engineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2014-05
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Description
Modern systems that measure dynamical phenomena often have limitations as to how many sensors can operate at any given time step. This thesis considers a sensor scheduling problem in which the source of a diffusive phenomenon is to be localized using single point measurements of its concentration. With a

Modern systems that measure dynamical phenomena often have limitations as to how many sensors can operate at any given time step. This thesis considers a sensor scheduling problem in which the source of a diffusive phenomenon is to be localized using single point measurements of its concentration. With a linear diffusion model, and in the absence of noise, classical observability theory describes whether or not the system's initial state can be deduced from a given set of linear measurements. However, it does not describe to what degree the system is observable. Different metrics of observability have been proposed in literature to address this issue. Many of these methods are based on choosing optimal or sub-optimal sensor schedules from a predetermined collection of possibilities. This thesis proposes two greedy algorithms for a one-dimensional and two-dimensional discrete diffusion processes. The first algorithm considers a deterministic linear dynamical system and deterministic linear measurements. The second algorithm considers noise on the measurements and is compared to a Kalman filter scheduling method described in published work.
ContributorsNajam, Anbar (Author) / Cochran, Douglas (Thesis advisor) / Turaga, Pavan (Committee member) / Wang, Chao (Committee member) / Arizona State University (Publisher)
Created2016
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Description

Modeling of transcriptional regulatory networks (TRNs) has been increasingly used to dissect the nature of gene regulation. Inference of regulatory relationships among transcription factors (TFs) and genes, especially among multiple TFs, is still challenging. In this study, we introduced an integrative method, LogicTRN, to decode TF–TF interactions that form TF

Modeling of transcriptional regulatory networks (TRNs) has been increasingly used to dissect the nature of gene regulation. Inference of regulatory relationships among transcription factors (TFs) and genes, especially among multiple TFs, is still challenging. In this study, we introduced an integrative method, LogicTRN, to decode TF–TF interactions that form TF logics in regulating target genes. By combining cis-regulatory logics and transcriptional kinetics into one single model framework, LogicTRN can naturally integrate dynamic gene expression data and TF-DNA-binding signals in order to identify the TF logics and to reconstruct the underlying TRNs. We evaluated the newly developed methodology using simulation, comparison and application studies, and the results not only show their consistence with existing knowledge, but also demonstrate its ability to accurately reconstruct TRNs in biological complex systems.

ContributorsYan, Bin (Author) / Guan, Daogang (Author) / Wang, Chao (Author) / Wang, Junwen (Author) / He, Bing (Author) / Qin, Jing (Author) / Boheler, Kenneth R. (Author) / Lu, Aiping (Author) / Zhang, Ge (Author) / Zhu, Hailong (Author) / College of Health Solutions (Contributor)
Created2017-10-19
Description

Effective DNA translocation into nanochannels is critical for advancing genome mapping and future single-molecule DNA sequencing technologies. We present the design and hydrodynamic study of a diamond-shaped gradient pillar array connected to nanochannels for enhancing the success of DNA translocation events. Single-molecule fluorescence imaging is utilized to interrogate the hydrodynamic

Effective DNA translocation into nanochannels is critical for advancing genome mapping and future single-molecule DNA sequencing technologies. We present the design and hydrodynamic study of a diamond-shaped gradient pillar array connected to nanochannels for enhancing the success of DNA translocation events. Single-molecule fluorescence imaging is utilized to interrogate the hydrodynamic interactions of the DNA with this unique structure, evaluate key DNA translocation parameters, including speed, extension, and translocation time, and provide a detailed mapping of the translocation events in nanopillar arrays coupled with 10 and 50 μm long channels. Our analysis reveals the important roles of diamond-shaped nanopillars in guiding DNA into as small as 30 nm channels with minimized clogging, stretching DNA to nearly 100% of their dyed contour length, inducing location-specific straddling of DNA at nanopillar interfaces, and modulating DNA speeds by pillar geometries. Importantly, all critical features down to 30 nm wide nanochannels are defined using standard photolithography and fabrication processes, a feat aligned with the requirement of high-volume, low-cost production.

ContributorsWang, Chao (Author) / Bruce, Robert L. (Author) / Duch, Elizabeth A. (Author) / Patel, Jyotica V. (Author) / Smith, Joshua T. (Author) / Astier, Yann (Author) / Wunsch, Benjamin H. (Author) / Meshram, Siddharth (Author) / Galan, Armand (Author) / Scerbo, Chris (Author) / Pereira, Michael A. (Author) / Wang, Deqiang (Author) / Colgan, Evan G. (Author) / Lin, Qinghuang (Author) / Stolovitzky, Gustavo (Author) / Ira A. Fulton Schools of Engineering (Contributor)
Created2015-02-01
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Description

The stability of cheerleading stunts is crucial to athlete safety and team success. Consistency in stunt technique contributes to success in stunting skills, giving a team the tools to win competitions. Increased stunt technique reduces the chances of falls and the severity of those falls. Proper technique also prevents injuries

The stability of cheerleading stunts is crucial to athlete safety and team success. Consistency in stunt technique contributes to success in stunting skills, giving a team the tools to win competitions. Increased stunt technique reduces the chances of falls and the severity of those falls. Proper technique also prevents injuries caused by improper positions that place pressure on the lower back and shoulders. Bases must maintain strong technique with proper lines of support in order to maximize stunt stability. Through exploration of the EmbeddedML system, involving a neural network implemented using a SensorTile, cheerleading motions can be successfully classified. Using this system, it is possible to identify motions that result in both weak and injurious positions almost instantly. By alerting athletes to these incorrect motions, improper stunt technique can be corrected quickly and without the involvement of a coach. This automated technique correction would be incredibly beneficial to the sport of competitive cheerleading

ContributorsOspina, Lauren (Author) / Wang, Chao (Thesis director) / Chakrabarti, Chaitali (Committee member) / Barrett, The Honors College (Contributor) / Electrical Engineering Program (Contributor)
Created2022-05
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Description
Quantifying molecular interactions is critical to the understanding of many biological processes and drug screening. To date, various detection techniques have been developed to determine the binding kinetics. However, because most of the mainstream detection technologies detect signals that scale with the mass of ligands bond to the sensor surface,

Quantifying molecular interactions is critical to the understanding of many biological processes and drug screening. To date, various detection techniques have been developed to determine the binding kinetics. However, because most of the mainstream detection technologies detect signals that scale with the mass of ligands bond to the sensor surface, it is still challenging to quantify the binding kinetics of small molecules. To address this problem, two different detection technologies, charge-sensitive optical detection (CSOD) and critical angle reflection (CAR), are developed for label-free detection of molecular interactions with the ability to detect a wide range of molecules including small molecules. In particular, CSOD technique detects the charge rather than the mass of a molecule with an optical fiber. However, the effective charge of a molecule decreases with the buffer ionic strength. For this reason, the previous CSOD works with diluted buffers, which could affect the measured molecular binding kinetics. Here a technique capable of detecting molecular binding kinetics in normal ionic strength buffers is presented. An H-shaped sample well was developed to overcome this problem. With this new design, the binding kinetics between G-protein-coupled receptors (GPCRs) and their small molecule ligands were measured in normal buffer. To further improve the signal-to-noise ratio of CSOD and move it toward high-throughput detection, CSOD was implemented with a quadrant-cell detector to achieve detection in higher frequency range and decrease low-frequency noise.This improved CSOD technique is capable for direct quantification of binding kinetics of phage-displayed peptides to their target protein using the whole phages. CAR imaging can be performed on surface plasmon resonance (SPR) imaging setups. It was shown that CAR is capable of measuring molecular interactions including proteins, nucleic acids and cell-based detections. In addition, it was shown that CAR can detect small molecule bindings and intracellular signals beyond SPR sensing limit. CAR exhibits several distinct characteristics over SPR, including tunable sensitivity and dynamic range, deeper vertical sensing range, and fluorescence compatibility. CAR is anticipated to have the ability to expand SPR capability in small molecule detection, whole cell-based detection, simultaneous fluorescence imaging, and broader conjugation chemistry.
ContributorsLiang, Runli (Author) / Wang, Shaopeng (Thesis advisor) / Blain Christen, Jennifer (Thesis advisor) / Jing, Tianwei (Committee member) / Wang, Chao (Committee member) / Arizona State University (Publisher)
Created2021
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Description
Design and development of optical sensors for the detection of specific targets, e.g., ions, molecules, proteins, light polarizations, is one of the most essential research topics in the field of nanophotonics that paves the way for significant technological progressions in chemical and biomarker detections, polarimetric imaging and other sensing related

Design and development of optical sensors for the detection of specific targets, e.g., ions, molecules, proteins, light polarizations, is one of the most essential research topics in the field of nanophotonics that paves the way for significant technological progressions in chemical and biomarker detections, polarimetric imaging and other sensing related applications. In this dissertation, three designs of optical sensors based on plasmonic and dielectric nanostructures are thoroughly studied for the applications in chemicals, biomarkers and light polarization detection. Firstly, a plasmonic nanoantenna structure, which is composed of complementary anisotropic nanobars and nanoapertures featuring strong localized electric field enhancement at nanogap region, demonstrates both high sensitivity refractometric detection and specific infrared fingerprint detection for chemical sensing. Specifically, the sensor can probe monolayer thin octadecanethiol with a large resonance shift of 136 nm and all four characteristic infrared fingerprints detected. Secondly, a bio-inspired double-layered metasurface structure, which is made of dielectric nanoantenna and plasmonic nanogratings, mediates strong optical chirality and enables the selection of circularly polarized light handedness (extinction ratio ≥ 35) with high transmission efficiency (≥ 80%). The structure can be further integrated on-chip with linear polarizers for highly precise full-Stokes polarimetric detection with minimum transmission loss. Lastly, a gold nanoparticle based colorimetric assay is designed for high sensitivity, specificity and rapid detection of infectious diseases related biomarkers. The complete design workflows from critical reagents productions, rapid detection protocol to assay characterizations are extensively studied. Detection of Ebola virus disease biomarker, secreted glycoprotein, within 20 minutes are experimentally demonstrated with limit of detection down to ~40 pM and a broad detection range from 10 pM to 1 µM. The designs of the three sensors propose novel and versatile design concepts for the development of sensing devices in the detection of chemicals, biomarkers and light polarization. The efforts in the fundamental theoretical analysis and experimental demonstrations are expected to provide valuable contents to the optical sensor researches and to potentially inspire new sensor designs for broad sensing applications in the future.
ContributorsChen, Xiahui (Author) / Wang, Chao (Thesis advisor) / Zhao, Yuji (Committee member) / Wang, Liping (Committee member) / Goryll, Michael (Committee member) / Arizona State University (Publisher)
Created2021
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Description
Biodiversity has been declining during the last decades due to habitat loss, landscape deterioration, environmental change, and human-related activities. In addition to its economic and cultural value, biodiversity plays an important role in keeping an environment’s ecosystem in balance. Disrupting such processes can reduce the provision of natural resources such

Biodiversity has been declining during the last decades due to habitat loss, landscape deterioration, environmental change, and human-related activities. In addition to its economic and cultural value, biodiversity plays an important role in keeping an environment’s ecosystem in balance. Disrupting such processes can reduce the provision of natural resources such as food and water, which in turn yields a direct threat to human health. Protecting and restoring natural areas is fundamental to preserve biodiversity and to mitigate the effects of ongoing environmental change. Unfortunately, it is impossible to protect every critical area due to resource limitations, requiring the use of advanced decision tools for the design of conservation plans. This dissertation studies three problems on the design of wildlife corridors and reserves that include patch-specific conservation decisions under spatial, operational, ecological, and biological requirements. In addition to the ecological impact of each problem’s solution, this dissertation contributes a set of formulations, valid inequalities, and pre-processing and solution algorithms for optimization problems with spatial requirements. The first problem is a utility-based corridor design problem to connect fragmented habitats, where each patch has a utility value reflecting its quality. The corridor must satisfy geometry requirements such as a connectivity and minimum width. We propose a mix-integer programming (MIP) model to maximize the total utility of the corridor under the given geometry requirements as well as a budget constraint to reflect the acquisition (or restoration) cost of the selected patches. To overcome the computational difficulty when solving large-scale instances, we develop multiple acceleration techniques, including a brand-and-cut algorithm enhanced with problem-specific valid inequalities and a bound-improving heuristic triggered at each integer node in the branch-and-bound exploration. We test the proposed model and solution algorithm using large-scale fabricated instances and a real case study for the design of an ecological corridor for the Florida Panther. Our modeling framework is able to solve instances of up to 1500 patches within 2 hours to optimality or with a small optimality gap. The second problem introduces the species movement across the fragmented landscape into the corridor design problem. The premise is that dispersal dynamics, if available, must inform the design to account for the corridor’s usage by the species. To this end, we propose a spatial discrete-time absorbing Markov chain (DTMC) approach to represent species dispersal and develop short- and long-term landscape usage metrics. We explore two different types of design problems: open and closed corridors. An open corridor is a sequence of landscape patches used by the species to disperse out of a habitat. For this case, we devise a dynamic programming algorithm that implicitly enumerates possible corridors and finds that of maximum probability. The second problem is to find a closed corridor of maximum probability that connects two fragmented habitats. To solve this problem variant, we extended the framework from the utility-based corridor design problem by blending the recursive Markov chain equations with a network flow nonlinear formulation. The third problem leverages on the DTMC approach to explore a reserve design problem with spatial requirements like connectivity and compactness. We approximate the compactness using the concept of maximum reserve diameter, i.e., the largest distance allowed between two patch in the reserve. To solve this problem, we devise a two-stage approach that balances the trade-off between reserve usage probability and compactness. The first stage's problem is to detect a subset of patches of maximum usage probability, while the second stage's problem imposes the geometry requirements on the optimal solution obtained from the first stage. To overcome the computational difficulty of large-scale landscapes, we develop tailored solution algorithms, including a warm-up heuristic to initialize the branch-and-bound exploration, problem-specific valid inequalities, and a decomposition strategy that sequentially solves smaller problems on landscape partitions.
ContributorsWang, Chao (Author) / Sefair, Jorge A. (Thesis advisor) / Mirchandani, Pitu (Committee member) / Pavlic, Theodore (Committee member) / Tong, Daoqin (Committee member) / Arizona State University (Publisher)
Created2021
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Description
This dissertation aims to study the electron and spin transport, scattering in two dimensional pseudospin-1 lattice systems, hybrid systems of topological insulator and magnetic insulators, and molecule chain systems. For pseudospin-1 systems, the energy band consists of a pair of Dirac cones and a flat band through the connecting point

This dissertation aims to study the electron and spin transport, scattering in two dimensional pseudospin-1 lattice systems, hybrid systems of topological insulator and magnetic insulators, and molecule chain systems. For pseudospin-1 systems, the energy band consists of a pair of Dirac cones and a flat band through the connecting point of the cones. First, contrary to the conditional wisdom that flatband can localize electrons, I find that in a non-equilibrium situation where a constant electric field is suddenly switched on, the flat band can enhance the resulting current in both the linear and nonlinear response regimes compared to spin-1/2 system. Second, in the setup of massive pseudospin-1 electron scattering over a gate potential scatterer, I discover the large resonant skew scattering called super skew scattering, which does not arise in the corresponding spin-1/2 system and massless pseudospin-1 system. Third, by applying an appropriate gate voltage to generate a cavity in an alpha-T3 lattice, I find the exponential decay of the quasiparticles from a chaotic cavity, with a one-to-one correspondence between the exponential decay rate and the Berry phase for the entire family of alpha-T3 materials. Based on the hybrid system of a ferromagnetic insulator on top of a topological insulator, I first investigate the magnetization dynamics of a pair of ferromagnetic insulators deposited on the surface of a topological insulator. The spin polarized current on the surface of topological insulator can affect the magnetization of the two ferromagnetic insulators through proximity effect, which in turn modulates the electron transport, giving rise to the robust phase locking between the two magnetization dynamics. Second, by putting a skyrmion structure on top of a topological insulator, I find robust electron skew scattering against skyrmion structure even with deformation, due to the emergence of resonant modes. The chirality of molecule can lead to spin polarized transport due to the spin orbit interaction. I investigate spin transport through a chiral polyacetylene molecule and uncover the emergence of spin Fano resonances as a manifestation of the chiral induced spin selectivity effect.
ContributorsWang, Chengzhen (Author) / Lai, Ying-Cheng (Thesis advisor) / Yu, Hongbin (Committee member) / Wang, Chao (Committee member) / Zhao, Yuji (Committee member) / Arizona State University (Publisher)
Created2021
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Description
The development of biosensing platforms not only has an immediate lifesaving effect but also has a significant socio-economic impact. In this dissertation, three very important biomarkers with immense importance were chosen for further investigation, reducing the technological gap and improving their sensing platform.Firstly, gold nanoparticles (AuNP) aggregation and sedimentation-based assays

The development of biosensing platforms not only has an immediate lifesaving effect but also has a significant socio-economic impact. In this dissertation, three very important biomarkers with immense importance were chosen for further investigation, reducing the technological gap and improving their sensing platform.Firstly, gold nanoparticles (AuNP) aggregation and sedimentation-based assays were developed for the sensitive, specific, and rapid detection of Ebola virus secreted glycoprotein (sGP)and severe acute respiratory syndrome coronavirus 2 (SARS-COV2) receptor-binding domain (RBD) antigens. An extensive study was done to develop a complete assay workflow from critical nanobody generation to optimization of AuNP size for rapid detection. A rapid portable electronic reader costing (<$5, <100 cm3), and digital data output was developed. Together with the developed workflow, this portable electronic reader showed a high sensitivity (limit of detection of ~10 pg/mL, or 0.13 pM for sGP and ~40 pg/mL, or ~1.3 pM for RBD in diluted human serum), a high specificity, a large dynamic range (~7 logs), and accelerated readout within minutes. Secondly, A general framework was established for small molecule detection using plasmonic metal nanoparticles through wide-ranging investigation and optimization of assay parameters with demonstrated detection of Cannabidiol (CBD). An unfiltered assay suitable for personalized dosage monitoring was developed and demonstrated. A portable electronic reader demonstrated optoelectronic detection of CBD with a limit of detection (LOD) of <100 pM in urine and saliva, a large dynamic range (5 logs), and a high specificity that differentiates closely related Tetrahydrocannabinol (THC). Finally, with careful biomolecular design and expansion of the portable reader to a dual-wavelength detector the classification of antibodies based on their affinity to SARS-COV2 RBD and their ability to neutralize the RBD from binding to the human Angiotensin-Converting Enzyme 2 (ACE2) was demonstrated with the capability to detect antibody concentration as low as 1 pM and observed neutralization starting as low as 10 pM with different viral load and variant. This portable, low-cost, and versatile readout system holds great promise for rapid, digital, and portable data collection in the field of biosensing.
ContributorsIkbal, Md Ashif (Author) / Wang, Chao (Thesis advisor) / Goryll, Michael (Committee member) / Zhao, Yuji (Committee member) / Wang, Shaopeng (Committee member) / Arizona State University (Publisher)
Created2022