We welcome the opportunity to respond to the commentaries on our paper—The Mouse That Trolled—by Hardy, Sarnoff , Cordova, and Feldman. Their comments are academic criticism in the very best sense. We also take the opportunity to update on recent legal actions, which we had not predicted. This opportunity enriches our narrative history of the patenting of the APPswe mutation for early onset Alzheimer's disease, and we hope the continued saga is of interest.