Matching Items (32)
Description
Rabies disease remains enzootic among raccoons, skunks, foxes and bats in the United States. It is of primary concern for public-health agencies to control spatial spread of rabies in wildlife and its potential spillover infection of domestic animals and humans. Rabies is invariably fatal in wildlife if untreated, with a non-negligible incubation period. Understanding how this latency affects spatial spread of rabies in wildlife is the concern of chapter 2 and 3. Chapter 1 deals with the background of mathematical models for rabies and lists main objectives. In chapter 2, a reaction-diffusion susceptible-exposed-infected (SEI) model and a delayed diffusive susceptible-infected (SI) model are constructed to describe the same epidemic process -- rabies spread in foxes. For the delayed diffusive model a non-local infection term with delay is resulted from modeling the dispersal during incubation stage. Comparison is made regarding minimum traveling wave speeds of the two models, which are verified using numerical experiments. In chapter 3, starting with two Kermack and McKendrick's models where infectivity, death rate and diffusion rate of infected individuals can depend on the age of infection, the asymptotic speed of spread $c^\ast$ for the cumulated force of infection can be analyzed. For the special case of fixed incubation period, the asymptotic speed of spread is governed by the same integral equation for both models. Although explicit solutions for $c^\ast$ are difficult to obtain, assuming that diffusion coefficient of incubating animals is small, $c^\ast$ can be estimated in terms of model parameter values. Chapter 4 considers the implementation of realistic landscape in simulation of rabies spread in skunks and bats in northeast Texas. The Finite Element Method (FEM) is adopted because the irregular shapes of realistic landscape naturally lead to unstructured grids in the spatial domain. This implementation leads to a more accurate description of skunk rabies cases distributions.
ContributorsLiu, Hao (Author) / Kuang, Yang (Thesis advisor) / Jackiewicz, Zdzislaw (Committee member) / Lanchier, Nicolas (Committee member) / Smith, Hal (Committee member) / Thieme, Horst (Committee member) / Arizona State University (Publisher)
Created2013
Description
In a 2004 paper, John Nagy raised the possibility of the existence of a hypertumor \emph{i.e.}, a focus of aggressively reproducing parenchyma cells that invade part or all of a tumor. His model used a system of nonlinear ordinary differential equations to find a suitable set of conditions for which these hypertumors exist. Here that model is expanded by transforming it into a system of nonlinear partial differential equations with diffusion, advection, and a free boundary condition to represent a radially symmetric tumor growth. Two strains of parenchymal cells are incorporated; one forming almost the entirety of the tumor while the much more aggressive strain
appears in a smaller region inside of the tumor. Simulations show that if the aggressive strain focuses its efforts on proliferating and does not contribute to angiogenesis signaling when in a hypoxic state, a hypertumor will form. More importantly, this resultant aggressive tumor is paradoxically prone to extinction and hypothesize is the cause of necrosis in many vascularized tumors.
appears in a smaller region inside of the tumor. Simulations show that if the aggressive strain focuses its efforts on proliferating and does not contribute to angiogenesis signaling when in a hypoxic state, a hypertumor will form. More importantly, this resultant aggressive tumor is paradoxically prone to extinction and hypothesize is the cause of necrosis in many vascularized tumors.
ContributorsAlvarez, Roberto L (Author) / Milner, Fabio A (Thesis advisor) / Nagy, John D. (Committee member) / Kuang, Yang (Committee member) / Thieme, Horst (Committee member) / Mahalov, Alex (Committee member) / Smith, Hal (Committee member) / Arizona State University (Publisher)
Created2014
Description
In 1984, Sinnott used $p$-adic measures on $\mathbb{Z}_p$ to give a new proof of the Ferrero-Washington Theorem for abelian number fields by realizing $p$-adic $L$-functions as (essentially) the $Gamma$-transform of certain $p$-adic rational function measures. Shortly afterward, Gillard and Schneps independently adapted Sinnott's techniques to the case of $p$-adic $L$-functions associated to elliptic curves with complex multiplication (CM) by realizing these $p$-adic $L$-functions as $Gamma$-transforms of certain $p$-adic rational function measures. The results in the CM case give the vanishing of the Iwasawa $mu$-invariant for certain $mathbb{Z}_p$-extensions of imaginary quadratic fields constructed from torsion points of CM elliptic curves.
In this thesis, I develop the theory of $p$-adic measures on $mathbb{Z}_p^d$, with particular interest given to the case of $d>1$. Although I introduce these measures within the context of $p$-adic integration, this study includes a strong emphasis on the interpretation of $p$-adic measures as $p$-adic power series. With this dual perspective, I describe $p$-adic analytic operations as maps on power series; the most important of these operations is the multivariate $Gamma$-transform on $p$-adic measures.
This thesis gives new significance to product measures, and in particular to the use of product measures to construct measures on $mathbb{Z}_p^2$ from measures on $mathbb{Z}_p$. I introduce a subring of pseudo-polynomial measures on $mathbb{Z}_p^2$ which is closed under the standard operations on measures, including the $Gamma$-transform. I obtain results on the Iwasawa-invariants of such pseudo-polynomial measures, and use these results to deduce certain continuity results for the $Gamma$-transform. As an application, I establish the vanishing of the Iwasawa $mu$-invariant of Yager's two-variable $p$-adic $L$-function from measure theoretic considerations.
In this thesis, I develop the theory of $p$-adic measures on $mathbb{Z}_p^d$, with particular interest given to the case of $d>1$. Although I introduce these measures within the context of $p$-adic integration, this study includes a strong emphasis on the interpretation of $p$-adic measures as $p$-adic power series. With this dual perspective, I describe $p$-adic analytic operations as maps on power series; the most important of these operations is the multivariate $Gamma$-transform on $p$-adic measures.
This thesis gives new significance to product measures, and in particular to the use of product measures to construct measures on $mathbb{Z}_p^2$ from measures on $mathbb{Z}_p$. I introduce a subring of pseudo-polynomial measures on $mathbb{Z}_p^2$ which is closed under the standard operations on measures, including the $Gamma$-transform. I obtain results on the Iwasawa-invariants of such pseudo-polynomial measures, and use these results to deduce certain continuity results for the $Gamma$-transform. As an application, I establish the vanishing of the Iwasawa $mu$-invariant of Yager's two-variable $p$-adic $L$-function from measure theoretic considerations.
ContributorsZinzer, Scott Michael (Author) / Childress, Nancy (Thesis advisor) / Bremner, Andrew (Committee member) / Fishel, Susanna (Committee member) / Jones, John (Committee member) / Spielberg, John (Committee member) / Arizona State University (Publisher)
Created2015
Description
Since Duffin and Schaeffer's introduction of frames in 1952, the concept of a frame has received much attention in the mathematical community and has inspired several generalizations. The focus of this thesis is on the concept of an operator-valued frame (OVF) and a more general concept called herein an operator-valued frame associated with a measure space (MS-OVF), which is sometimes called a continuous g-frame. The first of two main topics explored in this thesis is the relationship between MS-OVFs and objects prominent in quantum information theory called positive operator-valued measures (POVMs). It has been observed that every MS-OVF gives rise to a POVM with invertible total variation in a natural way. The first main result of this thesis is a characterization of which POVMs arise in this way, a result obtained by extending certain existing Radon-Nikodym theorems for POVMs. The second main topic investigated in this thesis is the role of the theory of unitary representations of a Lie group G in the construction of OVFs for the L^2-space of a relatively compact subset of G. For G=R, Duffin and Schaeffer have given general conditions that ensure a sequence of (one-dimensional) representations of G, restricted to (-1/2,1/2), forms a frame for L^{2}(-1/2,1/2), and similar conditions exist for G=R^n. The second main result of this thesis expresses conditions related to Duffin and Schaeffer's for two more particular Lie groups: the Euclidean motion group on R^2 and the (2n+1)-dimensional Heisenberg group. This proceeds in two steps. First, for a Lie group admitting a uniform lattice and an appropriate relatively compact subset E of G, the Selberg Trace Formula is used to obtain a Parseval OVF for L^{2}(E) that is expressed in terms of irreducible representations of G. Second, for the two particular Lie groups an appropriate set E is found, and it is shown that for each of these groups, with suitably parametrized unitary duals, the Parseval OVF remains an OVF when perturbations are made to the parameters of the included representations.
ContributorsRobinson, Benjamin (Author) / Cochran, Douglas (Thesis advisor) / Moran, William (Thesis advisor) / Boggess, Albert (Committee member) / Milner, Fabio (Committee member) / Spielberg, John (Committee member) / Arizona State University (Publisher)
Created2014
Description
Persistence theory provides a mathematically rigorous answer to the question of population survival by establishing an initial-condition- independent positive lower bound for the long-term value of the population size. This study focuses on the persistence of discrete semiflows in infinite-dimensional state spaces that model the year-to-year dynamics of structured populations. The map which encapsulates the population development from one year to the next is approximated at the origin (the extinction state) by a linear or homogeneous map. The (cone) spectral radius of this approximating map is the threshold between extinction and persistence. General persistence results are applied to three particular models: a size-structured plant population model, a diffusion model (with both Neumann and Dirichlet boundary conditions) for a dispersing population of males and females that only mate and reproduce once during a very short season, and a rank-structured model for a population of males and females.
ContributorsJin, Wen (Author) / Thieme, Horst (Thesis advisor) / Milner, Fabio (Committee member) / Quigg, John (Committee member) / Smith, Hal (Committee member) / Spielberg, John (Committee member) / Arizona State University (Publisher)
Created2014
Description
In 1968, phycologist M.R. Droop published his famous discovery on the functional relationship between growth rate and internal nutrient status of algae in chemostat culture. The simple notion that growth is directly dependent on intracellular nutrient concentration is useful for understanding the dynamics in many ecological systems. The cell quota in particular lends itself to ecological stoichiometry, which is a powerful framework for mathematical ecology. Three models are developed based on the cell quota principal in order to demonstrate its applications beyond chemostat culture.
First, a data-driven model is derived for neutral lipid synthesis in green microalgae with respect to nitrogen limitation. This model synthesizes several established frameworks in phycology and ecological stoichiometry. The model demonstrates how the cell quota is a useful abstraction for understanding the metabolic shift to neutral lipid production that is observed in certain oleaginous species.
Next a producer-grazer model is developed based on the cell quota model and nutrient recycling. The model incorporates a novel feedback loop to account for animal toxicity due to accumulation of nitrogen waste. The model exhibits rich, complex dynamics which leave several open mathematical questions.
Lastly, disease dynamics in vivo are in many ways analogous to those of an ecosystem, giving natural extensions of the cell quota concept to disease modeling. Prostate cancer can be modeled within this framework, with androgen the limiting nutrient and the prostate and cancer cells as competing species. Here the cell quota model provides a useful abstraction for the dependence of cellular proliferation and apoptosis on androgen and the androgen receptor. Androgen ablation therapy is often used for patients in biochemical recurrence or late-stage disease progression and is in general initially effective. However, for many patients the cancer eventually develops resistance months to years after treatment begins. Understanding how and predicting when hormone therapy facilitates evolution of resistant phenotypes has immediate implications for treatment. Cell quota models for prostate cancer can be useful tools for this purpose and motivate applications to other diseases.
First, a data-driven model is derived for neutral lipid synthesis in green microalgae with respect to nitrogen limitation. This model synthesizes several established frameworks in phycology and ecological stoichiometry. The model demonstrates how the cell quota is a useful abstraction for understanding the metabolic shift to neutral lipid production that is observed in certain oleaginous species.
Next a producer-grazer model is developed based on the cell quota model and nutrient recycling. The model incorporates a novel feedback loop to account for animal toxicity due to accumulation of nitrogen waste. The model exhibits rich, complex dynamics which leave several open mathematical questions.
Lastly, disease dynamics in vivo are in many ways analogous to those of an ecosystem, giving natural extensions of the cell quota concept to disease modeling. Prostate cancer can be modeled within this framework, with androgen the limiting nutrient and the prostate and cancer cells as competing species. Here the cell quota model provides a useful abstraction for the dependence of cellular proliferation and apoptosis on androgen and the androgen receptor. Androgen ablation therapy is often used for patients in biochemical recurrence or late-stage disease progression and is in general initially effective. However, for many patients the cancer eventually develops resistance months to years after treatment begins. Understanding how and predicting when hormone therapy facilitates evolution of resistant phenotypes has immediate implications for treatment. Cell quota models for prostate cancer can be useful tools for this purpose and motivate applications to other diseases.
ContributorsPacker, Aaron (Author) / Kuang, Yang (Thesis advisor) / Nagy, John (Committee member) / Smith, Hal (Committee member) / Kostelich, Eric (Committee member) / Kang, Yun (Committee member) / Arizona State University (Publisher)
Created2014
Description
In this thesis, I investigate the C*-algebras and related constructions that arise from combinatorial structures such as directed graphs and their generalizations. I give a complete characterization of the C*-correspondences associated to directed graphs as well as results about obstructions to a similar characterization of these objects for generalizations of directed graphs. Viewing the higher-dimensional analogues of directed graphs through the lens of product systems, I give a rigorous proof that topological k-graphs are essentially product systems over N^k of topological graphs. I introduce a "compactly aligned" condition for such product systems of graphs and show that this coincides with the similarly-named conditions for topological k-graphs and for the associated product systems over N^k of C*-correspondences. Finally I consider the constructions arising from topological dynamical systems consisting of a locally compact Hausdorff space and k commuting local homeomorphisms. I show that in this case, the associated topological k-graph correspondence is isomorphic to the product system over N^k of C*-correspondences arising from a related Exel-Larsen system. Moreover, I show that the topological k-graph C*-algebra has a crossed product structure in the sense of Larsen.
ContributorsPatani, Nura (Author) / Kaliszewski, Steven (Thesis advisor) / Quigg, John (Thesis advisor) / Bremner, Andrew (Committee member) / Kawski, Matthias (Committee member) / Spielberg, John (Committee member) / Arizona State University (Publisher)
Created2011
Description
The theory of geometric quantum mechanics describes a quantum system as a Hamiltonian dynamical system, with a projective Hilbert space regarded as the phase space. This thesis extends the theory by including some aspects of the symplectic topology of the quantum phase space. It is shown that the quantum mechanical uncertainty principle is a special case of an inequality from J-holomorphic map theory, that is, J-holomorphic curves minimize the difference between the quantum covariance matrix determinant and a symplectic area. An immediate consequence is that a minimal determinant is a topological invariant, within a fixed homology class of the curve. Various choices of quantum operators are studied with reference to the implications of the J-holomorphic condition. The mean curvature vector field and Maslov class are calculated for a lagrangian torus of an integrable quantum system. The mean curvature one-form is simply related to the canonical connection which determines the geometric phases and polarization linear response. Adiabatic deformations of a quantum system are analyzed in terms of vector bundle classifying maps and related to the mean curvature flow of quantum states. The dielectric response function for a periodic solid is calculated to be the curvature of a connection on a vector bundle.
ContributorsSanborn, Barbara (Author) / Suslov, Sergei K (Thesis advisor) / Suslov, Sergei (Committee member) / Spielberg, John (Committee member) / Quigg, John (Committee member) / Menéndez, Jose (Committee member) / Jones, Donald (Committee member) / Arizona State University (Publisher)
Created2011
Description
In complex consumer-resource type systems, where diverse individuals are interconnected and interdependent, one can often anticipate what has become known as the tragedy of the commons, i.e., a situation, when overly efficient consumers exhaust the common resource, causing collapse of the entire population. In this dissertation I use mathematical modeling to explore different variations on the consumer-resource type systems, identifying some possible transitional regimes that can precede the tragedy of the commons. I then reformulate it as a game of a multi-player prisoner's dilemma and study two possible approaches for preventing it, namely direct modification of players' payoffs through punishment/reward and modification of the environment in which the interactions occur. I also investigate the questions of whether the strategy of resource allocation for reproduction or competition would yield higher fitness in an evolving consumer-resource type system and demonstrate that the direction in which the system will evolve will depend not only on the state of the environment but largely on the initial composition of the population. I then apply the developed framework to modeling cancer as an evolving ecological system and draw conclusions about some alternative approaches to cancer treatment.
ContributorsKareva, Irina (Author) / Castillo-Chavez, Carlos (Thesis advisor) / Collins, James (Committee member) / Nagy, John (Committee member) / Smith, Hal (Committee member) / Arizona State University (Publisher)
Created2012
Description
Bacteriophage (phage) are viruses that infect bacteria. Typical laboratory experiments show that in a chemostat containing phage and susceptible bacteria species, a mutant bacteria species will evolve. This mutant species is usually resistant to the phage infection and less competitive compared to the susceptible bacteria species. In some experiments, both susceptible and resistant bacteria species, as well as phage, can coexist at an equilibrium for hundreds of hours. The current research is inspired by these observations, and the goal is to establish a mathematical model and explore sufficient and necessary conditions for the coexistence. In this dissertation a model with infinite distributed delay terms based on some existing work is established. A rigorous analysis of the well-posedness of this model is provided, and it is proved that the susceptible bacteria persist. To study the persistence of phage species, a "Phage Reproduction Number" (PRN) is defined. The mathematical analysis shows phage persist if PRN > 1 and vanish if PRN < 1. A sufficient condition and a necessary condition for persistence of resistant bacteria are given. The persistence of the phage is essential for the persistence of resistant bacteria. Also, the resistant bacteria persist if its fitness is the same as the susceptible bacteria and if PRN > 1. A special case of the general model leads to a system of ordinary differential equations, for which numerical simulation results are presented.
ContributorsHan, Zhun (Author) / Smith, Hal (Thesis advisor) / Armbruster, Dieter (Committee member) / Kawski, Matthias (Committee member) / Kuang, Yang (Committee member) / Thieme, Horst (Committee member) / Arizona State University (Publisher)
Created2012